Expression :

Owner Public
URN urn:agi-Expression:inout-urn:agi-llid:6774:out-urn:agi-llid:598::positive
Entities STAT3 --+> BCL2L1
References 54
Connectivity 2
Effect positive
MedLine Reference 11850821:6
Sentence NPM-ALK expression caused enhanced Bcl-x(L) transcription, largely mediated by Stat3.
MedLine Reference 11807093:7
Sentence Stat3 is essential for upregulation of Reg-2 and Bcl-xl expression in lesioned motoneurons.
CellType neural
Organism Mus musculus
MedLine Reference 12454861:7
Sentence The transcription factors Stat3 and NF-kappaB induce increased Bcl-x(L) expression in the premalignant lesions and tumor cells.
Organism Mus musculus
MedLine Reference 10679091:10246
Journal J. Immunol
Journal Reference v164 i5 p2533
Journal Link http://www.jimmunol.org/cgi/content/full/164/5/2533
Organism Mus musculus
MedLine Reference 15755911:10300
Journal Mol. Pharm
Journal Reference v67 i6 p1861
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/67/6/1861
Organism Rattus norvegicus
MedLine Reference 12640143:10180
Journal PNAS
Journal Reference v100 i7 p4138
Journal Link http://www.pnas.org/cgi/content/full/100/7/4138
MedLine Reference 12237322:10219
Journal Mol. Pharm
Journal Reference v62 i4 p765
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/62/4/765
MedLine Reference 15994947:10277
Journal Cancer Res
Journal Reference v65 i13 p5720
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/65/13/5720
Organism Mus musculus
MedLine Reference 10760290:10179
Journal PNAS
Journal Reference v97 i8 p4227
Journal Link http://www.pnas.org/cgi/content/full/97/8/4227
Organism Mus musculus
MedLine Reference 14659041:4
MedLine Reference 15604280:3
Organism Mus musculus
MedLine Reference 10023775:3
Organism Mus musculus
MedLine Reference 11751528:0
MedLine Reference 12592339:9
CellType monocyte
MedLine Reference 11474132:0
MedLine Reference 9766567:6
Organism Rattus norvegicus
MedLine Reference 11429412:10215
Journal J. Biol. Chem
Journal Reference v276 i34 p31839
Journal Link http://www.jbc.org/cgi/content/full/276/34/31839
MedLine Reference 14976049:10031
Journal Blood
Journal Reference v103 i12 p4630
Journal Link http://www.bloodjournal.org/cgi/content/full/103/12/4630
MedLine Reference 15070700:10231
Journal Blood
Journal Reference v103 i8 p3175
Journal Link http://www.bloodjournal.org/cgi/content/full/103/8/3175
MedLine Reference 12668584:10143
Journal Hypertension
Journal Reference v41 i5 p1156
Journal Link http://hyper.ahajournals.org/cgi/content/full/41/5/1156
Organism Rattus norvegicus
MedLine Reference 15197228:10137
Journal J. Exp. Med
Journal Reference v199 i12 p1701
Journal Link http://www.jem.org/cgi/content/full/199/12/1701
Organism Mus musculus
MedLine Reference 11279133:10025
Journal J. Biol. Chem
Journal Reference v276 i20 p16840
Journal Link http://www.jbc.org/cgi/content/full/276/20/16840
MedLine Reference 12517767:10106
Journal Cancer Res
Journal Reference v63 i1 p1
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/1/1
MedLine Reference 12023955:10216
Journal J. Biol. Chem
Journal Reference v277 i30 p27169
Journal Link http://www.jbc.org/cgi/content/full/277/30/27169
Organism Mus musculus
MedLine Reference 15037656:10387
Journal Mol. Cancer Res
Journal Reference v2 i3 p170
Journal Link http://mcr.aacrjournals.org/cgi/content/full/2/3/170
Organism Mus musculus
MedLine Reference 15805299:10107
Journal Cancer Res
Journal Reference v65 i7 p2956
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/65/7/2956
MedLine Reference 12067972:10169
Journal Cancer Res
Journal Reference v62 i12 p3351
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/12/3351
MedLine Reference 14996930:10200
Journal Cell Sci
Journal Reference v117 i7 p989
Journal Link http://jcs.biologists.org/cgi/content/full/117/7/989
MedLine Reference 10521404:10035
Journal Genes & Dev
Journal Reference v13 i19 p2604
Journal Link http://www.genesdev.org/cgi/content/full/13/19/2604
Organism Mus musculus
MedLine Reference 14500688:10041
Journal J. Immunol
Journal Reference v171 i7 p3863
Journal Link http://www.jimmunol.org/cgi/content/full/171/7/3863
MedLine Reference 15958595:10271
Journal Cancer Res
Journal Reference v65 i12 p5454
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/65/12/5454
Organism Mus musculus
MedLine Reference 11094078:10049
Journal Mol. Cell. Biol
Journal Reference v20 i24 p9271
Journal Link http://mcb.asm.org/cgi/content/full/20/24/9271
Organism Rattus norvegicus
MedLine Reference 118005808:11011
Journal Blood
Journal Reference v103 i7 p2438
Journal Link http://www.bloodjournal.org/cgi/content/full/103/7/2438
MedLine Reference 11756159:10238
Journal Blood
Journal Reference v99 i1 p102
Journal Link http://www.bloodjournal.org/cgi/content/full/99/1/102
MedLine Reference 11756179:10157
Journal Blood
Journal Reference v99 i1 p252
Journal Link http://www.bloodjournal.org/cgi/content/full/99/1/252
MedLine Reference 11171987:10152
Journal PNAS
Journal Reference v98 i4 p1543
Journal Link http://www.pnas.org/cgi/content/full/98/4/1543
Organism Mus musculus
MedLine Reference 12730073:10286
Journal AJRCMB
Journal Reference v29 i4 p513
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/29/4/513
MedLine Reference 12134064:10243
Journal Mol. Biol. Cell
Journal Reference v13 i7 p2233
Journal Link http://www.molbiolcell.org/cgi/content/full/13/7/2233
MedLine Reference 11751528:1
Sentence Inhibition of this pathway by the JAK selective kinase inhibitor AG490 or dominant-negative Stat3 protein results in down-regulation of Bcl-x(L) expression and enhanced sensitivity to Fas-mediated apoptosis.
Source Curated
MedLine Reference 11807093:1016
Sentence Stat3 is essential for upregulation of Reg-2 and Bcl-xl expression in lesioned motoneurons.
CellType neural
Journal J. Cell Biol
Journal Reference v156 i2 p287 (2002)
Journal Link http://www.jcb.org/cgi/content/full/156/2/287
Organism mouse
Source Curated
MedLine Reference 10409196:1035
Sentence Constitutive activation of Stat3 in human myeloma cells suppressed apoptosis and induced expression of Bcl-x L (Catlett-Falcone et al. 1999 ).
Journal Heart Circul
Journal Reference v277 i1 pH183 (1999)
Journal Link http://ajpheart.physiology.org/cgi/content/full/277/1/H183
Source Curated
MedLine Reference 10537273:1141
Sentence Whereas the precise mechanism by which Stat3eta mediates apoptosis in B16 cells is still under investigation, our recent studies in human myeloma cells demonstrated that Stat3eta inhibits expression of the Bcl-x L protein (17) .
Journal Cancer Res
Journal Reference v59 i20 p5059 (1999)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/59/20/5059
Organism mouse
CellLineName B16
Source Curated
MedLine Reference 11328823:1295
Journal J. Biol. Chem
Journal Reference v276 i27 p25605 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/27/25605
Source Curated
MedLine Reference 11756159:1238
Journal Blood
Journal Reference v99 i1 p102 (2002)
Journal Link http://www.bloodjournal.org/cgi/content/full/99/1/102
Source Curated
MedLine Reference 12237322:1219
Journal Mol. Pharm
Journal Reference v62 i4 p765 (2002)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/62/4/765
Source Curated
MedLine Reference 12640143:1177
Journal PNAS
Journal Reference v100 i7 p4138 (1996)
Journal Link http://www.pnas.org/cgi/content/full/100/7/4138
Source Curated
MedLine Reference 11046136:1049
Journal Mol. Cell. Biol
Journal Reference v20 i24 p9271 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/24/9271
Tissue endothelial
Source Curated
MedLine Reference 11432872:1021
Journal J. Biol. Chem
Journal Reference v276 i35 p32678 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/35/32678
Organism mouse
Source Curated
MedLine Reference 14523036:5
Organism mouse
Organ liver
Source Curated
MedLine Reference 11369758:1196
Journal J. Biol. Chem
Journal Reference v276 i28 p26107 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/28/26107
Organism mouse
CellLineName MC/9
Source Curated
MedLine Reference 11431352:1232
Journal Cancer Res
Journal Reference v61 i13 p5137 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/13/5137
Organism mouse
CellLineName 35
Source Curated
MedLine Reference 12067972:1138
Journal Cancer Res
Journal Reference v62 i12 p3351 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/12/3351
Source Curated
MedLine Reference 12492118:1145
Journal Mol. Cancer Ther
Journal Reference v1 i10 p851 (2002)
Journal Link http://mct.aacrjournals.org/cgi/content/full/1/10/851
Source Curated
MedLine Reference 12867595:1165
Journal PNAS
Journal Reference v100 i16 p9342 (1996)
Journal Link http://www.pnas.org/cgi/content/full/100/16/9342
Organism mouse
CellLineName MCF7
Source Curated