Protein : STAT3
Owner Public
URN urn:agi-llid:6774
Hugo ID 11364
Connectivity 1862
Name STAT3
Description signal transducer and activator of transcription 3
Notes transcription factor that plays a role in induction of gene expression during acute phase response [RGD]
RGD ID 3772
MGI ID 103038
Cell Localization Nucleus
Pathway p40 MAPK
IL29
HGF
IL28B
IL27
IL22
IFN alpha
Growth Hormone
IL21
Jak-Stat Pathway from IL6 Receptor
IL17A
EGF signaling
LIF
IL9
Cardiotrophin-1 like
IL15
IL20
Leptin
CNTF
Cardiotrophin-1
M-CSF
KITLG
IL2
IL12
IL26
PDGF signaling
MAPK-ERK in Growth and Differentiation
IL11
Inhibition of Apoptosis
IL-6 signaling
IL7
IL6
IL5
IL10
IL19
IL24
IL1
oncostatin M
IL3
IL23
EGF
IL18
G-CSF
AGTR1 -> STAT3 signaling pathway
IFNAR -> STAT3 signaling pathway
IFNGR -> STAT3 signaling pathway
AGTR2 -> STAT3 signaling pathway
ALK -> STAT3 signaling pathway
EGFR/ERBB2 -> STAT3 signaling pathway
OPRs -> STAT3 signaling pathway
IGF1R -> STAT3 signaling pathway
OSMR -> STAT3 signaling pathway
IL10R -> STAT3 signaling pathway
IL11R -> STAT3 signalling pathway
PDGFRs -> STAT3 signaling pathway
PECAM1 -> STAT3 signaling pathway
IL12R -> STAT3 signaling pathway
BDKRB2 -> STAT3 signaling pathway
IL13R -> STAT3 signaling pathway
PRLR -> STAT3 signaling pathway
EPHA4 -> STAT3 signaling pathway
IL15R -> STAT3 signaling pathway
PTAFR -> STAT3 signaling pathway
EPOR -> STAT3 signaling pathway
IL1R -> STAT3 signaling pathway
CCKBR -> STAT3 signaling pathway
IL21R -> STAT3 signaling pathway
IL22R -> STAT3 signaling pathway
IL2R -> STAT3 signaling pathway
CCR1 -> STAT3 signaling pathway
FGFR1 -> STAT3 signaling pathway
IL31R -> STAT3 signaling pathway
CCR2 -> STAT3 signaling pathway
IL3R -> STAT3 signaling pathway
CCR5 -> STAT3 signaling pathway
FGFR3 -> STAT3 signaling pathway
IL5R -> STAT3 signaling pathway
CD2 -> STAT3 signaling pathway
IL6R -> STAT3 signaling pathway
IL7R -> STAT3 signaling pathway
IL9R -> STAT3 signaling pathway
TEK -> STAT3 signaling pathway
INSR -> STAT3 signaling pathway
CD28 -> STAT3 signaling pathway
CD4 -> STAT3 signaling pathway
KDR -> STAT3 signaling pathway
KIT -> STAT3 signaling pathway
ADRA1B -> STAT3 signaling pathway
GHR -> STAT3 signaling pathway
LEPR -> STAT3 signaling pathway
CSF1R -> STAT3 signaling pathway
LIFR/CNTFR -> STAT3 signaling pathway
ADRB1 -> STAT3 signaling pathway
CSF2R -> STAT3 signaling pathway
MET -> STAT3 signaling pathway
CSF3R -> STAT3 signaling pathway
ADRB2 -> STAT3 signaling pathway
CXCR4 -> STAT3 signaling pathway
ADRB3 -> STAT3 signaling pathway
MPL -> STAT3 signaling pathway
HTR2A -> STAT3 signaling pathway
TNFRSF1A -> STAT3 signaling pathway
ICAM2 -> STAT3 signaling pathway
TNFRSF5 -> STAT3 signaling pathway
Group Sh2
Transcription factors
signal transduction
intracellular signaling cascade
cytokine and chemokine mediated signaling pathway
JAK-STAT cascade
eye photoreceptor cell differentiation
cell motility
transcription
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
regulation of body size
glucose homeostasis
thermoregulation
acute-phase response
sexual reproduction
eating behavior
cytoplasm
nucleus
plasma membrane
signal transducer activity
protein binding
calcium ion binding
DNA binding
transcription factor activity
protein dimerization activity
transcription factor binding
hematopoietin-interferon-class (D200-domain) cytokine receptor signal transducer activity
transcriptional activator activity
GenBank ID NC_000017
NM_139276
NP_644805
NM_003150
NP_003141
NM_213662
NP_998827
NT_010755
NW_926828
AC_000060
AC087691
AC107993
AF332508
AAK17196
AY572796
AAS66986
AF029311
AAB84254
AI631896
AJ012463
CAA10032
AK024535
AK092965
BC000627
AAH00627
BC008044
BC014482
AAH14482
BC029783
AAH29783
BC067119
BI461226
CB216860
CB321646
CF454565
L29277
AAA58374
P40763
Q8N2X9
Q9BXH2
NC_000077
NM_213659
NP_998824
NM_011486
NP_035616
NM_213660
NP_998825
NT_096143
NT_165773
NW_000040
NW_001072672
XM_001005155
XP_001005155
AB008160
AF246978
AAL59017
AF332507
AAK17195
AL591466
AI325183
AK004083
AK079406
AK145486
BAE26464
AK153005
BAE31645
AK153170
AK153472
BAE32023
AK192932
AK192951
AK193746
AK197148
AY299489
AAQ75418
AY299490
AAQ75419
BC003806
AAH03806
BC019168
AAH19168
BC037688
AAH37688
BG076355
BI079838
BY301717
L29278
AAA37254
U06922
AAA19452
U08378
AAA56668
U30709
AAC52612
P42227
NC_005109
NM_012747
NP_036879
NW_001084656
NW_047339
AC_000078
BC087025
AAH87025
X91810
CAA62920
P52631
Source Curated
LocusLink ID 6774
20848
25125
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 102582
Alias APRF
FLJ20882
MGC16063
signal transducer and activator of transcription 3
DNA-binding protein APRF
acute-phase response factor
AW109958
1110034C02Rik
acute phase response factor
MGC93551
GO ID 0005509
0005062
0004871
0003700
0008134
0007259
0006953
0006928
0019221
0007242
0000122
0007399
0006355
0005737
0005634
0003677
0005515
0046983
0016563
0042755
0001754
0042593
0040014
0006357
0019953
0007165
0001659
0006350
0006366
0005886
Swiss-Prot Accession P40763
Q8N2X9
Q9BXH2
P42227
P52631
Unigene ID Hs.463059
Hs.643543
Mm.249934
Rn.10247