Protein : PTPN11


Owner	Public
URN	urn:agi-llid:5781
Hugo ID	9644
Connectivity	817
Name	PTPN11
Description	protein tyrosine phosphatase, non-receptor type 11
Notes	catalyzes the tyrosine dephosphorylation of para-nitrophenylphosphate, nicotinic acetylcholine receptor, myelin basic protein, and other proteins [RGD]


RGD ID	3447


MGI ID	99511


Pathway	HGF
	Insulin Receptor Signaling
	Jak-Stat Pathway from IL6 Receptor
	Insulin pathway
	PDGFRB
	PDGFRA
	IL-6 signaling
	EPHA2
	AGTR1 -> ELK1-SRF signaling pathway
	AGTR1 -> ELK4-SRF signaling pathway
	EDG2 -> ELK4-SRF signaling pathway
	AGTR1 -> TP53 signaling pathway
	AGTR2 -> CREB1 signaling pathway
	AGTR2 -> ELK1-SRF signaling pathway
	AGTR2 -> ELK4-SRF signaling pathway
	AGTR2 -> TP53 signaling pathway
	PECAM1 -> SP1 signaling pathway
	EPOR -> ELK1-SRF signaling pathway
	EPOR -> ELK4-SRF signaling pathway
	SELE -> ELK1-SRF signaling pathway
	EPOR -> FOS signaling pathway
	SELE -> ELK4-SRF signaling pathway
	IL6R -> CEBPB signaling pathway
	IL6R -> ELK1-SRF signaling pathway
	IL6R -> ELK4-SRF signaling pathway
	ADRA1B -> ELK1-SRF signaling pathway
	GHR -> ELK1-SRF signaling pathway
	ADRA1B -> ELK4-SRF signaling pathway
	GHR -> ELK4-SRF signaling pathway
	GHR -> MYC signaling pathway
	LEPR -> ELK1-SRF signaling pathway
	ADRA1B -> STAT3 signaling pathway
	LEPR -> ELK4-SRF signaling pathway
	AGTR1 -> CREB1 signaling pathway
	EDG2 -> ELK1-SRF signaling pathway


Group	Phosphatases
	Sh2
	signal transduction
	intracellular signaling cascade
	nerve growth factor receptor signaling pathway
	activation of MAPK activity
	axonogenesis
	DNA damage checkpoint
	regulation of protein export from nucleus
	protein amino acid dephosphorylation
	sensory perception of sound
	membrane fraction
	stress fiber
	cell junction
	protein binding
	hydrolase activity
	phosphoprotein phosphatase activity
	protein tyrosine phosphatase activity
	non-membrane spanning protein tyrosine phosphatase activity
	receptor activity


Source	Curated


Alias	CFC
	NS1
	SHP2
	BPTP3
	PTP2C
	PTP-1D
	SH-PTP2
	SH-PTP3
	MGC14433
	protein tyrosine phosphatase, non-receptor type 11
	Noonan syndrome 1
	protein-tyrosine phosphatase 2C
	Syp
	PTP1D
	SAP-2
	SHP-2
	AW536184
	2700084A17Rik
	SH2 domain-containing protein tyrosine phosphatase-2
	encodes catalytic domain
	protein tyrosine phosphatase SH-PTP2
	SH-PTP2 protein tyrosine phosphatase non-receptor type 11
	SH-PTP2 protein tyrosine phosphatase, non-receptor type 11