Protein : IL6


Owner	Public
URN	urn:agi-llid:3569
Hugo ID	6018
Connectivity	4861
Name	IL6
Description	interleukin 6
Notes	a cytokine involved in development and possibly in neurodegenerative processes [RGD]


RGD ID	2901


MGI ID	96559


Cell Localization	Extracellular


Pathway	HGF
	Jak-Stat Pathway from IL6 Receptor
	IL-6 signaling
	IL6
	IL-1 and IL-6 signaling
	IL6R -> CEBPB signaling pathway
	IL6R -> ELK1-SRF signaling pathway
	IL6R -> ELK4-SRF signaling pathway
	IL6R -> STAT1 signaling pathway
	IL6R -> STAT3 signaling pathway
	IL6ST -> STAT5B signaling pathway
	Aquaporin


Group	Ligands
	cell-cell signaling
	cell surface receptor linked signal transduction
	positive regulation of JAK-STAT cascade
	neutrophil apoptosis
	negative regulation of cell proliferation
	positive regulation of cell proliferation
	negative regulation of chemokine biosynthesis
	immune response
	humoral immune response
	acute-phase response
	regulation of circadian sleep-wake cycle, non-REM sleep
	extracellular region
	extracellular space
	protein binding
	cytokine activity
	growth factor activity
	interleukin-6 receptor binding


GenBank ID	NC_000007
	NM_000600
	NP_000591
	NT_007819
	NT_079592
	NW_923240
	AC_000050
	AC_000068
	AC073072
	AAS07539
	AF372214
	AAK48987
	CH236948
	EAL24265
	X04402
	CAA27990
	Y00081
	CAA68278
	BC015511
	AAH15511
	BT019748
	AAV38553
	BT019749
	AAV38554
	CR450296
	CAG29292
	CR590965
	CR626263
	M14584
	AAA52728
	M18403
	AAA52729
	M29150
	AAA59154
	M54894
	AAC41704
	S56892
	AAD13886
	X04403
	CAA27991
	X04430
	CAA28026
	X04602
	CAA28268
	P05231
	Q75MH2
	Q8N6X1
	A09363
	CAA00839
	NC_000071
	NM_031168
	NP_112445
	NT_162294
	NW_000226
	NW_001030787
	AC_000027
	AC112933
	M20572
	AAA39302
	M24221
	AAA68814
	M36996
	X51457
	CAA35824
	AK089780
	AK150440
	BAE29562
	AK152189
	BAE31020
	J03783
	AAA39301
	X06203
	CAA29560
	X54542
	CAA38411
	P08505
	NC_005103
	NM_012589
	NP_036721
	NW_001084822
	NW_047683
	AC_000072
	M26745
	AAA41430
	M26744
	AAA77659
	P20607


Source	Curated


LocusLink ID	3569
	16193
	24498


Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus


OMIM ID	147620
	148000
	166710


Alias	HGF
	HSF
	BSF2
	IL-6
	IFNB2
	interleukin 6 (interferon, beta 2)
	interleukin 6
	ILg6
	Interleukin 6 (interferon beta 2)


GO ID	0005125
	0005138
	0006953
	0007166
	0007267
	0006959
	0008285
	0045079
	0001781
	0008284
	0005576
	0005615
	0008083
	0005515
	0006955
	0046427
	0045188


Swiss-Prot Accession	P05231
	Q75MH2
	Q8N6X1
	P08505
	P20607


MedScan ID	3569


Unigene ID	Hs.512234
	Mm.1019
	Rn.9873


LocatorString	pmquery:aquaporin