Expression :

Owner Public
URN urn:agi-Expression:inout-urn:agi-llid:2002:out-urn:agi-llid:2353::positive
Entities ELK1 --+> FOS
References 57
Connectivity 2
Effect positive
MedLine Reference 10747974:1070
Sentence Elk-1 binds the serum response element motif in the c- fos promoter, thereby inducing c- fos transcription ( 47 ).
Journal J. Biol. Chem
Journal Reference v275 i21 p16064 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/21/16064
Source Curated
MedLine Reference 11245588:1391
Sentence Phosphorylation of Elk-1 by ERK, JNK, and p38 MAP kinases increases ternary complex formation with the SRF, thereby activating c-Fos gene transcription.
Journal Cell Phys
Journal Reference v280 i4 pC719 (2001)
Journal Link http://ajpcell.physiology.org/cgi/content/full/280/4/C719
Source Curated
MedLine Reference 10551817:1128
Sentence Recently, Elk-1 was shown to be phosphorylated during hypoxic conditions by MAPK , inducing the transcription of the c- fos gene ( 30 ).
Journal J. Biol. Chem
Journal Reference v274 i46 p32631 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/46/32631
CellLineName CCL39
Source Curated
MedLine Reference 10806199:1232
Sentence A ternary complex of SRF and Elk-1 or Sap1 bound to SRE has been shown to induce expression of both the c- fos ( 40-42 , 46 ) and egr-1 genes ( 47 ).
Journal J. Biol. Chem
Journal Reference v275 i29 p22418 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/29/22418
Tissue lymph
Organism mouse
Source Curated
MedLine Reference 9501093:1294
Sentence We propose that both inactivation of KSR and activation of ERK are required to achieve maximum activation/phosphorylation of Elk-1 during receptor tyrosine kinase and Ras signaling which induce the expression of c-fos.
Journal EMBO
Journal Reference v17 i6 p1717 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/6/1717
Organism C-elegans
Source Curated
Tissue cortex
Source Curated
MedLine Reference 9478985:1038
Journal J. Biol. Chem
Journal Reference v273 i9 p5279 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/9/5279
Source Curated
MedLine Reference 8824287:1021
Journal J. Biol. Chem
Journal Reference v271 i42 p26335 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/42/26335
Source Curated
MedLine Reference 12621033:1220
Journal J. Biol. Chem
Journal Reference v278 i20 p17775 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/20/17775
Source Curated
MedLine Reference 12643264:1045
CellType t cell
Journal J. Biol. Chem
Journal Reference v278 i11 p9235 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/11/9235
CellLineName PC 12
Source Curated
MedLine Reference 12391160:1034
Journal Mol. Cell. Biol
Journal Reference v22 i22 p7929 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/22/7929
Organism mouse
Source Curated
MedLine Reference 9642252:1220
Journal J. Biol. Chem
Journal Reference v273 i27 p16905 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/27/16905
Organism rat
Source Curated
MedLine Reference 9218459:1033
Journal J. Biol. Chem
Journal Reference v272 i29 p18222 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/29/18222
Organism mouse
Source Curated
MedLine Reference 12239223:1202
Journal J. Biol. Chem
Journal Reference v277 i50 p48755 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/50/48755
Organism rat
Source Curated
MedLine Reference 12145292:1036
Journal J. Biol. Chem
Journal Reference v277 i43 p40911 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/43/40911
Organism mouse
Source Curated
MedLine Reference 11292836:1187
Journal J. Biol. Chem
Journal Reference v276 i25 p22941 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/25/22941
Organism rat
Source Curated
MedLine Reference 9774460:1066
CellType osteoclast
Journal J. Biol. Chem
Journal Reference v273 i43 p28355 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/43/28355
Source Curated
MedLine Reference 8910314:1030
CellType t cell
Journal J. Biol. Chem
Journal Reference v271 i44 p27366 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/44/27366
Source Curated
MedLine Reference 9321399:1147
Journal EMBO
Journal Reference v16 i20 p6200 (1997)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/16/20/6200
Source Curated
MedLine Reference 9770464:1042
Journal PNAS
Journal Reference v95 i21 p12202 (1998)
Journal Link http://www.pnas.org/cgi/content/full/95/21/12202
Source Curated
CellType dendritic
Tissue cortex
CellLineName Smith
Source Curated
CellType neural
CellLineName DRG
Source Curated
MedLine Reference 10864939:1213
Journal J. Neurosci
Journal Reference v20 i13 p4821 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/13/4821
Tissue muscle
Organism rat
Source Curated
MedLine Reference 9834073:1188
CellType t cell
Journal J. Immunol
Journal Reference v161 i11 p5930 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/161/11/5930
Organism mouse
Source Curated
MedLine Reference 9813041:1008
Journal J. Biol. Chem
Journal Reference v273 i47 p31327 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/47/31327
Organism mouse
Source Curated
MedLine Reference 9624179:1023
CellType fibroblast
Journal J. Biol. Chem
Journal Reference v273 i25 p15794 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/25/15794
Organism rat
Source Curated
MedLine Reference 11470779:1268
Journal J. Biol. Chem
Journal Reference v276 i38 p35636 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/38/35636
Tissue mesangia
Organism rat
Source Curated
MedLine Reference 10196167:1019
Journal J. Biol. Chem
Journal Reference v274 i16 p10897 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/16/10897
Tissue mesangia
Organism rat
Source Curated
MedLine Reference 9528972:1185
Journal Endocrinology
Journal Reference v139 i4 p1863 (1998)
Journal Link http://endo.endojournals.org/cgi/content/full/139/4/1863
Organism mouse
Source Curated
MedLine Reference 9729506:1194
Journal Renal Phys
Journal Reference v275 i3 pF343 (1998)
Journal Link http://ajprenal.physiology.org/cgi/content/full/275/3/F343
Organism rat
CellLineName BK
Source Curated
MedLine Reference 9356505:1150
Journal PNAS
Journal Reference v94 i23 p12655 (1997)
Journal Link http://www.pnas.org/cgi/content/full/94/23/12655
Organism mouse
Organ brain
Source Curated
MedLine Reference 12181441:1243
CellType keratinocyte
Journal Mol. Pharm
Journal Reference v62 i3 p647 (2002)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/62/3/647
Organism mouse
CellLineName PC 12
Source Curated
CellType t cell
Journal J. Exp. Med
Journal Reference v193 i3 p317 (2001)
Journal Link http://www.jem.org/cgi/content/full/193/3/317
Source Curated
MedLine Reference 11741977:1238
Journal J. Biol. Chem
Journal Reference v277 i13 p11368 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/13/11368
Source Curated
MedLine Reference 11454854:1033
Journal J. Biol. Chem
Journal Reference v276 i36 p33826 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/36/33826
Source Curated
MedLine Reference 9407028:1225
Journal Genes & Dev
Journal Reference v11 i24 p3351 (1997)
Journal Link http://www.genesdev.org/cgi/content/full/11/24/3351
Source Curated
MedLine Reference 9721691:1038
Journal Circulation Res
Journal Reference v83 i4 p345 (1998)
Journal Link http://circres.ahajournals.org/cgi/content/full/83/4/345
Organ heart
Source Curated
MedLine Reference 11035054:1267
Journal J. Immunol
Journal Reference v165 i8 p4217 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/165/8/4217
CellLineName COS I
Source Curated
MedLine Reference 11289149:1171
Journal Cancer Res
Journal Reference v61 i6 p2690 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/6/2690
CellLineName 293T
Source Curated
MedLine Reference 9409734:3
Tissue smooth muscle
Organism rat
CellLineName VSMCs
Source Curated
MedLine Reference 11157052:1027
CellType t cell
Journal J. Exp. Med
Journal Reference v193 i3 p317 (2001)
Journal Link http://www.jem.org/cgi/content/full/193/3/317
Organism mouse
Source Curated
MedLine Reference 10961986:1184
Journal J. Biol. Chem
Journal Reference v275 i48 p37311 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/48/37311
Organism mouse
Source Curated
MedLine Reference 12842891:1191
CellType t cell
Journal J. Biol. Chem
Journal Reference v278 i39 p37622 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/39/37622
Organism mouse
Source Curated
MedLine Reference 10749885:1162
Journal J. Biol. Chem
Journal Reference v275 i23 p17838 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/23/17838
Tissue epithelia
Organism mouse
CellLineName A 549
Source Curated
MedLine Reference 11283256:1338
Journal Mol. Cell. Biol
Journal Reference v21 i8 p2802 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/8/2802
Organism rat
Source Curated
MedLine Reference 11402055:1175
Journal J. Biol. Chem
Journal Reference v276 i34 p32094 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/34/32094
Tissue endoderm
Organism mouse
CellLineName F9
Source Curated
MedLine Reference 10891373:3
Tissue mesangia
Organism rat
Source Curated
MedLine Reference 8007980:3
CellType fibroblast
Organism mouse
Source Curated
MedLine Reference 7651411:2
Source Curated
MedLine Reference 7630721:2
Source Curated
MedLine Reference 7622446:1083
Journal J. Biol. Chem
Journal Reference v270 i28 p16483 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/28/16483
Source Curated
CellLineName PC 12
Source Curated
CellLineName PC 12
Source Curated
MedLine Reference 9096313:1081
Journal PNAS
Journal Reference v94 i7 p2869 (1997)
Journal Link http://www.pnas.org/cgi/content/full/94/7/2869
CellLineName FS4
Source Curated
MedLine Reference 12391846:0
CellType fibroblast
Tissue egg
Organism rat
CellLineName REF
Source Curated
MedLine Reference 9484987:1033
Journal ATVB
Journal Reference v18 i2 p227 (1998)
Journal Link http://atvb.ahajournals.org/cgi/content/full/18/2/227
Organism bovine
Source Curated
MedLine Reference 14729959:1242
Journal Mol. Cell. Biol
Journal Reference v24 i3 p1132 (2004)
Journal Link http://mcb.asm.org/cgi/content/full/24/3/1132
Organism mouse
Source Curated