ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-go:0004718:out-urn:agi-llid:6774::unknown
Entities JAK ---> STAT3
References 14
Connectivity 2
Effect unknown
MedLine Reference 10747872:1259
Sentence First, the activated receptor associates with JAKs, which phosphorylate STAT3.
Journal J. Biol. Chem
Journal Reference v275 i20 p15099 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/20/15099
Organism mouse
Source Curated
MedLine Reference 12649187:1173
Sentence The ability of JSI-124 to suppress phosphotyrosine levels of STAT3 suggests that this agent may interfere with the function of the upstream tyrosine kinases JAK and Src that are known to phosphorylate STAT3.
Journal Cancer Res
Journal Reference v63 i6 p1270 (2003)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/6/1270
CellLineName MB-468
Organism mouse
Source Curated
MedLine Reference 10666199:1022
Sentence The activated JAKs, in turn, phosphorylate and activate latent signal transducer and activator of transcription (STAT) family proteins, especially STAT1 and STAT3 (for reviews, see 1 and 11 ).
Journal Blood
Journal Reference v95 i4 p1264 (2000)
Journal Link http://www.bloodjournal.org/cgi/content/full/95/4/1264
CellLineName M1
Organism mouse
Tissue hematological
Source Curated
CellType megakaryocyte
MedLine Reference 9135145:1212
Sentence It has been proposed that STIP-1 provides a positive effect on signaling by interacting with non-phosphorylated STAT3 and facilitating phosphorylation of STAT3 by JAKs in response to IL-6 (Collum and Schindler, 1996 ); PKR, as demonstrated, exerts a negative effect on signaling by mediating STAT1 DNA binding and transactivation capacities.
Journal EMBO
Journal Reference v16 i6 p1291 (1997)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/16/6/1291
Organism mouse
Source Curated
MedLine Reference 11877294:1014
Sentence Introduction Materials and methods Results Discussion References Interleukin-6 (IL-6) has a variety of biologic functions in different cells 1 and is a growth factor for human myeloma cells. 2 IL-6 receptor complexes consist of the IL-6 receptor alpha chain (IL-6Ralpha) and gp130, the latter being commonly used as a signal-transducing molecule by the members of the IL-6 family of cytokines. 3 Upon IL-6 binding to the IL-6Ralpha, phosphorylated tyrosine residues in gp130 using Janus kinases (JAKs), such as Jak1 and Tyk2, recruit signal transducer and activator of transcription 3 (STAT3), which is also phosphorylated by the JAKs.
Journal Blood
Journal Reference v99 i6 p2172 (2002)
Journal Link http://www.bloodjournal.org/cgi/content/full/99/6/2172
Source Curated
MedLine Reference 14673162:1025
Journal Mol. Cell. Biol
Journal Reference v24 i1 p280 (2004)
Journal Link http://mcb.asm.org/cgi/content/full/24/1/280
Organism rat
Tissue astroglia
Source Curated
MedLine Reference 10982828:1026
Journal Mol. Cell. Biol
Journal Reference v20 i19 p7132 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/19/7132
Organism mouse
Source Curated
CellType neural
MedLine Reference 10207096:1212
Journal Mol. Cell. Biol
Journal Reference v19 i5 p3727 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/5/3727
Source Curated
MedLine Reference 9268355:1020
Journal J. Biol. Chem
Journal Reference v272 i35 p22118 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/35/22118
Organism rat
Organ liver
Source Curated
MedLine Reference 9083098:1040
Journal J. Biol. Chem
Journal Reference v272 i14 p9550 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/14/9550
Source Curated
MedLine Reference 12361954:1027
Journal J. Biol. Chem
Journal Reference v277 i51 p49134 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/51/49134
Organ liver
Source Curated
MedLine Reference 8675499:1220
Journal J. Biol. Chem
Journal Reference v271 i22 p13221 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/22/13221
CellLineName COS
Source Curated
MedLine Reference 11744720:1021
Journal J. Biol. Chem
Journal Reference v277 i8 p6676 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/8/6676
Organism mouse
Tissue vascular
Organ heart
Source Curated
MedLine Reference 11553624:1021
Journal J. Biol. Chem
Journal Reference v276 i45 p42534 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/45/42534
Organism mouse
Source Curated