ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-go:0004708:out-urn:agi-llid:5594::unknown
Entities ERK activator kinase ---> MAPK1
References 10
Connectivity 2
Effect unknown
MedLine Reference 9400369:1104
Sentence Phosphorylation of ERK2 by MAP kinase kinase decreases its electrophoretic mobility, thus allowing assessment of ERK2 phosphorylation state by Western blot. 25,26 Using an anti-ERK1 antibody, we visualized changes in the proportion between phosphorylated and unphosphorylated ERK2 in the course of our experiments (Fig 1B ).
Journal Circulation Res
Journal Reference v81 i6 p895 (1997)
Journal Link http://circres.ahajournals.org/cgi/content/full/81/6/895
Organ aorta
Source Curated
MedLine Reference 10066421:6
Organism rat
Organ brain
Source Curated
MedLine Reference 9724043:6
Organism bovine
Organ luteal
Source Curated
MedLine Reference 8393135:1
Organism rat
Source Curated
MedLine Reference 15713638:7
Organism mouse
Source Curated
MedLine Reference 8892054:7
Source Curated
CellType t cell
MedLine Reference 10415066:1030
Journal J. Immunol
Journal Reference v163 i3 p1611 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/3/1611
Tissue endothelial
Source Curated
CellType leukocyte
MedLine Reference 11425867:1294
Journal J. Cell Biol
Journal Reference v153 i7 p1355 (2001)
Journal Link http://www.jcb.org/cgi/content/full/153/7/1355
Source Curated
MedLine Reference 11726657:1057
Journal J. Biol. Chem
Journal Reference v277 i8 p6137 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/8/6137
Source Curated
CellType t cell
MedLine Reference 2335616053
Sentence MAPKK then phosphorylates MAPK (ERK) on Thr and Tyr residues at the activation-loop leading to its activation.
Journal Cell
Journal Reference v103 i2 p211 (2000)
Journal Link http://www.cell.com/cgi/content/full/103/2/211
Source Curated