Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:6655:inout-urn:agi-go:0003930:
Entities RAS small monomeric GTPase ---- SOS2
References 3
MedLine Reference 8995293:3
Sentence The E63K mutation, which impairs binding of guanine nucleotide releasing factor to Ras, alleviated suppression by S17N, consistent with sequestration of exchange factors as the mechanism for inhibition.
Organ heart
CellType myocyte
Organism Mus musculus
CellLineName Mv1Lu
MedLine Reference 11602579:1171
Sentence It has been described that Sos , a guanine nucleotide-releasing factor, can recruit Ras to the cytoplasmic membrane to carry out Ras/Raf-1/MEK signaling ( 20 , 25 ).
Journal J. Biol. Chem
Journal Reference v276 i51 p48549 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/51/48549
Organism drosophila
Source Curated
CellLineName HL 60
MedLine Reference 8995293:1011
Sentence The E63K mutation, which impairs binding of guanine nucleotide releasing factor to Ras, alleviated suppression by S17N, consistent with sequestration of exchange factors as the mechanism for inhibition.
Organ heart
CellType myocyte
Journal J. Biol. Chem
Journal Reference v272 i1 p525 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/1/525
Organism rat
Source Curated
CellLineName Mv1Lu