Protein : MYL2
Owner Public
URN urn:agi-llid:4633
Hugo ID 7583
Connectivity 159
Name MYL2
Description myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Notes MYL2 encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
RGD ID 1564245
MGI ID 97272
Pathway PKC in Myosine regulation
Erk-PI3K in Collagen Binding
Group Sh2
cytoskeleton organization and biogenesis
regulation of striated muscle contraction
cytoskeleton
myosin complex
motor activity
protein binding
calcium ion binding
structural constituent of muscle
GenBank ID NC_000012
NM_000432
NP_000423
NT_009775
NW_925395
AC_000055
AC002351
AF020768
AAB91993
BC015821
AAH15821
BC031006
AAH31006
BC031008
AAH31008
BX538165
CR456962
CAG33243
CR541957
CAG46755
M22815
AAA91832
S69022
AAB29658
X14332
CAA32510
X57542
CAA40761
X66141
CAA46931
P10916
Q14908
Q6IB42
Q7Z3Z1
NC_000071
NM_010861
NP_034991
NT_078458
NW_000236
NW_001030796
AC_000027
AC140353
AF302688
AAG40240
AK002367
BAB22045
AK146674
BAE27350
BC061144
AAH61144
M91602
AAA39796
P51667
NC_005111
NM_001035252
NP_001030329
NW_001084677
NW_047375
AC_000080
M11851
AAA41621
P08733
Source Curated
LocusLink ID 4633
17906
363925
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 160781
608758
Alias MLC2
CMH10
DKFZp779C0562
myosin light chain 2
MLC-2
Mlc2v
Mylpc
MLC-2v
myosin, light polypeptide 2, regulatory, cardiac, slow
myosin light chain 2v
ventricular myosin regulatory light chain
myosin light chain, phosphorylatable, cardiac ventricles
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
cardiac myosin light chain-2
GO ID 0005509
0003774
0005515
0008307
0006942
0005856
0016459
0007010
Swiss-Prot Accession P10916
Q14908
Q6IB42
Q7Z3Z1
P51667
P08733
Unigene ID Hs.75535
Mm.1529
Rn.37176