Protein : MYLK
Owner Public
URN urn:agi-llid:4638
Hugo ID 7590
Connectivity 489
Name MYLK
Description myosin, light polypeptide kinase (predicted)
Notes This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Seven transcript variants that produce seven isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin.
RGD ID 1310915
MGI ID 894806
Pathway PKC in Myosine regulation
Erk-PI3K in Collagen Binding
Group Kinases
cytoskeleton organization and biogenesis
protein amino acid phosphorylation
cytoskeleton
signal transducer activity
nucleotide binding
metal ion binding
calcium ion binding
magnesium ion binding
ATP binding
calmodulin binding
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
myosin light chain kinase activity
GenBank ID NC_000003
NM_053028
NP_444256
NM_053026
NP_444254
NM_053029
NP_444257
NM_053027
NP_444255
NM_053025
NP_444253
NM_005965
NP_005956
NM_053030
NP_444258
NM_053032
NP_444260
NM_053031
NP_444259
NT_005612
NW_921807
AC_000046
AC020634
AC023165
AC117381
AF096769
AAD51380
AF096770
AF096771
AAD51381
AB037663
BAB21504
AF069601
AAD15921
AF069602
AAD15922
AF069603
AAD15923
AF069604
AAD15924
AF096773
AAD54017
AF096774
AAD54018
AF096775
AAD54019
AF172084
AAQ13607
AK022278
AK127437
AY339601
AAQ02673
AY424269
AAR29061
AY424270
AAR29062
BC017811
BC034911
BC064420
AAH64420
BC064695
BC100761
AAI00762
BC100762
AAI00763
BC100763
AAI00764
BC107783
AAI07784
BM723621
BU678390
CA391484
CA391924
CA432076
CR749364
CAH18217
U48959
AAC18423
X85337
CAA59685
X90870
CAA62378
Y09530
CAA70723
Q15746
Q5MY99
Q5MYA0
Q68DK3
Q6LAL4
Q6P2N0
Q6ZNP1
Q7Z4F4
Q7Z4J0
Q9C0L5
Q9UBY6
NC_000082
NM_139300
NP_647461
NT_039624
NW_000107
NW_001030584
AC_000038
AC110166
AC154813
AF335470
AAK53241
AF542075
AAN63946
AAN63947
CT010574
AA688911
AF314149
AAG34169
AI117835
AI746549
AK018371
AK020638
AK044527
BAC31966
AK078556
AK162008
BAE36678
AK171889
AY237726
AAO85807
AY237727
AAO85808
BC034209
AAH34209
BC037721
BC038902
BC045197
AAH45197
BC058610
AAH58610
BC062265
BF451748
BG082901
Q6PDN3
NC_005110
XM_213611
XP_213611
NW_001084662
XM_001071705
XP_001071705
NW_047356
AC_000079
Source Curated
LocusLink ID 4638
107589
288057
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 600922
Alias KRP
MLCK
MLCK108
MLCK210
MSTP083
FLJ12216
DKFZp686I10125
myosin light chain kinase
AW489456
9530072E15Rik
A930019C19Rik
myosin, light polypeptide kinase
telokin
kinase-related protein
myosin, light polypeptide kinase (predicted)
GO ID 0005524
0005509
0005516
0016301
0000287
0004687
0000166
0004672
0004871
0016740
0006468
0046872
0004674
0007010
0005856
Swiss-Prot Accession Q15746
Q5MY99
Q5MYA0
Q68DK3
Q6LAL4
Q6P2N0
Q6ZNP1
Q7Z4F4
Q7Z4J0
Q9C0L5
Q9UBY6
Q6PDN3
Unigene ID Hs.556600
Mm.33360
Mm.393572