Protein : FYN


Owner	Public
URN	urn:agi-llid:2534
Hugo ID	4037
Connectivity	917
Name	FYN
Description	fyn proto-oncogene
Notes	may mediate tyrosine phosphorylation of Cbl protein in cerebellum in response to ethanol administration [RGD]


RGD ID	2641


MGI ID	95602


Pathway	Insulin Receptor Signaling
	EPHB3
	IL2
	MAPK-ERK in Growth and Differentiation
	EPHA4
	EPHA3
	Erk-PI3K in Collagen Binding
	Lck and Fyn in TCR activation
	IL3
	Integrin Signaling
	PTPRC -> BCL6 signaling pathway
	PLAUR -> ELK1-SRF signaling pathway
	PLAUR -> ELK4-SRF signaling pathway
	T-cell receptor -> AP-1 signaling pathway
	T-cell receptor -> NF-kB signaling pathway
	T-cell receptor -> NFAT5 signaling pathway
	T-cell receptor -> NFATC1 signaling pathway
	T-cell receptor -> NFATC2 signaling pathway
	T-cell receptor -> NFATC3 signaling pathway
	CD2 -> NFATC1 signaling pathway
	T-cell receptor -> NFATC4 signaling pathway
	IL7R -> FOXO1A signaling pathway
	IL7R -> FOXO3A signaling pathway
	IL7R -> NF-kB signaling pathway
	CD28 -> ATF1 signaling pathway
	CD28 -> ATF2 signaling pathway
	CD28 -> CREB1 signaling pathway
	CD28 -> CREBBP signaling pathway
	CD28 -> NF-kB signaling pathway
	CD28 -> NFAT5 signaling pathway
	CD28 -> NFATC1 signaling pathway
	CD28 -> NFATC2 signaling pathway
	CD28 -> NFATC3 signaling pathway
	CD28 -> NFATC4 signaling pathway
	CD28 -> STAT1 signaling pathway
	CD28 -> STAT3 signaling pathway
	CD28 -> STAT6 signaling pathway
	CHRNA7 -> CREB1 signaling pathway
	NCAM1 -> CREB1 signaling pathway
	NCAM1 -> ELK1-SRF signaling pathway
	NCAM1 -> ELK4-SRF signaling pathway
	NCAM1 -> MYC signaling pathway


Group	Kinases
	Sh2
	myelination
	regulation of neuronal synaptic plasticity
	intracellular signaling cascade
	ionotropic glutamate receptor signaling pathway
	T cell receptor signaling pathway
	protein kinase cascade
	neuron migration
	regulation of cell shape
	protein amino acid phosphorylation
	peptidyl-tyrosine phosphorylation
	calcium ion transport
	forebrain development
	feeding behavior
	learning
	visual learning
	cellular_component
	mitochondrial envelope
	nucleotide binding
	protein binding
	ATP binding
	identical protein binding
	tubulin binding
	transferase activity
	kinase activity
	protein kinase activity
	protein-tyrosine kinase activity
	non-membrane spanning protein tyrosine kinase activity


Source	Curated


OMIM ID	137025


Alias	SLK
	SYN
	MGC45350
	RP1-66H14.1
	protein-tyrosine kinase fyn
	src-like kinase
	c-syn protooncogene
	tyrosine kinase p59fyn(T)
	src/yes-related novel gene
	OKT3-induced calcium influx regulator
	proto-oncogene tyrosine-protein kinase fyn
	AI448320
	AW552119
	MGC115870
	Src Kinase p59
	fyn proto-oncogene