ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-go:0004707:out-urn:agi-llid:5595::unknown
Entities MEK ---> MAPK3
References 23
Connectivity 2
Effect unknown
MedLine Reference 9885231:1222
Sentence MEK, in turn, phosphorylates ERK1 and ERK2.
Journal Blood
Journal Reference v93 i2 p686 (1999)
Journal Link http://www.bloodjournal.org/cgi/content/full/93/2/686
Source Curated
CellType leukocyte
MedLine Reference 10098484:1256
Sentence Phosphorylation of p42/p44 by MEK leads to activation and translocation to the cell nucleus.
Journal Endocrinology
Journal Reference v140 i4 p1525 (1999)
Journal Link http://endo.endojournals.org/cgi/content/full/140/4/1525
CellLineName Rat1
Organism rat
Source Curated
CellType fibroblast
MedLine Reference 12591721:1021
Sentence Erk1 and Erk2 are phosphorylated by MEK, which, in turn, is activated via phosphorylation by kinases of the RAF family (8) .
Journal Cancer Res
Journal Reference v63 i4 p756 (2003)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/4/756
Source Curated
MedLine Reference 10383890:1192
Sentence Both enzymes appear to be present in approximately equal levels as observed by immunoblotting, suggesting that MEK is preferentially phosphorylating ERK1 or that the dephosphorylation of these proteins is differentially regulated in the tumor cells.
Journal Carcinogenesis
Journal Reference v20 i7 p1201 (1999)
Journal Link http://carcin.oupjournals.org/cgi/content/full/20/7/1201
Organism mouse
Source Curated
MedLine Reference 12444037:1033
Sentence Zhang and coworkers demonstrated that phosphorylated p38 MAP kinase is capable of forming a complex with ERK1/2, thereby preventing the phosphorylation of ERK1/2 by MEK ( 14 ). p38 MAP kinases are activated by a variety of agents, including environmental stress (e.g., reactive oxygen species, UV radiation), cytokines (e.g., interleukin [IL]-1????, tumor necrosis factor [TNF]- ), or growth factors such as EGF and PDGF ( 16 , 17 ).
Journal AJRCMB
Journal Reference v27 i6 p759 (2002)
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/27/6/759
Organism rat
Tissue mesenchyma
Source Curated
CellType myofibroblast
MedLine Reference 11466342:1134
Journal J. Immunol
Journal Reference v167 i3 p1263 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/167/3/1263
Organism mouse
Source Curated
CellType b cell
MedLine Reference 9278384:1120
Journal J. Biol. Chem
Journal Reference v272 i36 p22381 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/36/22381
Source Curated
CellType platelet
MedLine Reference 9148971:1112
Journal J. Biol. Chem
Journal Reference v272 i20 p13452 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/20/13452
CellLineName ML457
Organism mouse
Source Curated
MedLine Reference 8939933:1027
Journal J. Biol. Chem
Journal Reference v271 i47 p29903 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/47/29903
Organism mouse
Source Curated
MedLine Reference 12149254:1162
Journal J. Biol. Chem
Journal Reference v277 i41 p38205 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/41/38205
CellLineName HCT 116
Source Curated
MedLine Reference 10801816:1263
Journal J. Biol. Chem
Journal Reference v275 i31 p23911 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/31/23911
Organism rat
Source Curated
MedLine Reference 8626767:1151
Journal J. Biol. Chem
Journal Reference v271 i8 p4230 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/8/4230
Source Curated
MedLine Reference 7592642:1102
Journal J. Biol. Chem
Journal Reference v270 i41 p24315 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/41/24315
Organism mouse
Source Curated
MedLine Reference 12393886:1205
Journal J. Biol. Chem
Journal Reference v278 i3 p1975 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/3/1975
Organism mouse
Source Curated
MedLine Reference 12213812:1216
Journal J. Biol. Chem
Journal Reference v277 i45 p42830 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/45/42830
Organism rat
Source Curated
MedLine Reference 10954702:1128
Journal J. Biol. Chem
Journal Reference v275 i47 p37219 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/47/37219
Source Curated
CellType b cell
MedLine Reference 9564854:1043
Journal Endocrinology
Journal Reference v139 i5 p2423 (1998)
Journal Link http://endo.endojournals.org/cgi/content/full/139/5/2423
Organism mouse
Source Curated
CellType osteoblast
MedLine Reference 9108048:1121
Journal PNAS
Journal Reference v94 i8 p3742 (1997)
Journal Link http://www.pnas.org/cgi/content/full/94/8/3742
Source Curated
MedLine Reference 10319320:1027
Journal Mol. Endocrin
Journal Reference v13 i5 p692 (1999)
Journal Link http://mend.endojournals.org/cgi/content/full/13/5/692
Tissue endothelial
Source Curated
MedLine Reference 10207070:1341
Journal Mol. Cell. Biol
Journal Reference v19 i5 p3474 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/5/3474
CellLineName CHP 126
Organism bovine
Source Curated
MedLine Reference 15231676:4
CellLineName MCF7
Source Curated
MedLine Reference 10493724:1161
Journal J. Neurosci
Journal Reference v19 i19 p8234 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/19/8234
Organism rat
Source Curated
MedLine Reference 10640741:1207
Journal J. Immunol
Journal Reference v164 i3 p1277 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/3/1277
Organism mouse
Tissue microglia
Source Curated
CellType astrocyte