ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-go:0004707:out-urn:agi-llid:5594::unknown
Entities MEK ---> MAPK1
References 58
Connectivity 2
Effect unknown
MedLine Reference 9885231:1222
Sentence MEK, in turn, phosphorylates ERK1 and ERK2.
Journal Blood
Journal Reference v93 i2 p686 (1999)
Journal Link http://www.bloodjournal.org/cgi/content/full/93/2/686
Source Curated
CellType leukocyte
MedLine Reference 11245462:1203
Sentence ERK is phosphorylated by MEK, and SB203580 was also found to increase phospho-MEK (Fig. 6 A ) .
Journal Cancer Res
Journal Reference v61 i4 p1533 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/4/1533
Source Curated
MedLine Reference 9885215:1352
Sentence In yeast, Ste5 serves as a scaffolding protein that holds Ste11 (MAPKKK), Ste7 (MAPKK), and Fus3/Kss1 (MAPK) together in a productive kinase cascade. 54 An Ste5 analog has not been definitively identified in mammalian cells, but an attractive model would be for cAMP to modify this scaffolding protein in a way to enhance the ability of ERK to be phosphorylated by MEK.
Journal Blood
Journal Reference v93 i2 p537 (1999)
Journal Link http://www.bloodjournal.org/cgi/content/full/93/2/537
CellLineName 32D
Organism mouse
Source Curated
MedLine Reference 12444037:1033
Sentence Zhang and coworkers demonstrated that phosphorylated p38 MAP kinase is capable of forming a complex with ERK1/2, thereby preventing the phosphorylation of ERK1/2 by MEK ( 14 ). p38 MAP kinases are activated by a variety of agents, including environmental stress (e.g., reactive oxygen species, UV radiation), cytokines (e.g., interleukin [IL]-1????, tumor necrosis factor [TNF]- ), or growth factors such as EGF and PDGF ( 16 , 17 ).
Journal AJRCMB
Journal Reference v27 i6 p759 (2002)
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/27/6/759
Organism rat
Tissue mesenchyma
Source Curated
CellType myofibroblast
MedLine Reference 10733514:1027
Sentence Our group has recently shown that PKCdelta and Raf-1 translocate to the plasma membrane during the first few minutes of PMNL phagocytosis. 11 In most systems, Raf-1 then initiates the mitogen-activated protein (MAP) kinase cascade. 12 Raf-1 activates MEK, which then phosphorylates ERK. 13 , 14 Previously we showed that activation of the MAP kinases ERK2 and ERK1, as well as phospholipase D, are required for the ingestion of IgG-opsonized particles. 7 , 15 Others also have found ERK activity to increase during both FcR- and CR3-mediated phagocytosis 16 and the inhibition of the ERK pathway to inhibit phagocytosis and the oxidative burst. 17 The in vivo substrate for ERK2 during PMNL phagocytosis has not been determined.
Journal Blood
Journal Reference v95 i7 p2407 (2000)
Journal Link http://www.bloodjournal.org/cgi/content/full/95/7/2407
CellLineName PMNLs
Source Curated
CellType leukocyte
MedLine Reference 11443060:1223
Journal Cell Phys
Journal Reference v281 i2 pC603 (2001)
Journal Link http://ajpcell.physiology.org/cgi/content/full/281/2/C603
Source Curated
MedLine Reference 12124353:1172
Journal Cancer Res
Journal Reference v62 i14 p4142 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/14/4142
CellLineName RIE1
Organism rat
Source Curated
MedLine Reference 11479233:1206
Journal Cancer Res
Journal Reference v61 i15 p5911 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/15/5911
CellLineName HNSCC
Source Curated
CellType keratinocyte
MedLine Reference 12591721:1021
Journal Cancer Res
Journal Reference v63 i4 p756 (2003)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/4/756
Source Curated
MedLine Reference 9634402:1030
Journal Science
Journal Reference v280 i5367 p1212 (1998)
Journal Link http://www.sciencemag.org/cgi/content/full/280/5367/1212
Source Curated
MedLine Reference 9108048:1121
Journal PNAS
Journal Reference v94 i8 p3742 (1997)
Journal Link http://www.pnas.org/cgi/content/full/94/8/3742
Source Curated
MedLine Reference 14766974:1190
Journal PNAS
Journal Reference v101 i7 p1822 (1996)
Journal Link http://www.pnas.org/cgi/content/full/101/7/1822
CellLineName BLUE
Source Curated
MedLine Reference 10319320:1027
Journal Mol. Endocrin
Journal Reference v13 i5 p692 (1999)
Journal Link http://mend.endojournals.org/cgi/content/full/13/5/692
Tissue endothelial
Source Curated
MedLine Reference 10207070:1341
Journal Mol. Cell. Biol
Journal Reference v19 i5 p3474 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/5/3474
CellLineName CHP 126
Organism bovine
Source Curated
MedLine Reference 12897159:1232
Journal Mol. Cell. Biol
Journal Reference v23 i16 p5908 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/16/5908
CellLineName SH-SY5Y
Source Curated
MedLine Reference 12588996:1288
Journal Mol. Cell. Biol
Journal Reference v23 i5 p1786 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/5/1786
Organism mouse
Source Curated
Journal Cell Sci
Journal Reference v115 i8 p802e (1997)
Journal Link http://jcs.biologists.org/cgi/content/full/115/8/802e
Source Curated
MedLine Reference 8626767:1026
Journal J. Biol. Chem
Journal Reference v271 i8 p4230 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/8/4230
Tissue lymph
Source Curated
CellType t cell
MedLine Reference 8626525:1032
Journal J. Biol. Chem
Journal Reference v271 i14 p8300 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/14/8300
Source Curated
MedLine Reference 12379659:1031
Journal J. Biol. Chem
Journal Reference v278 i2 p1108 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/2/1108
Organism rat
Source Curated
MedLine Reference 12374792:1142
Journal J. Biol. Chem
Journal Reference v278 i1 p82 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/1/82
Source Curated
MedLine Reference 12237315:1203
Journal J. Biol. Chem
Journal Reference v277 i49 p47366 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/49/47366
CellLineName K 562
Organism mouse
Source Curated
MedLine Reference 12213812:1216
Journal J. Biol. Chem
Journal Reference v277 i45 p42830 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/45/42830
Organism rat
Source Curated
MedLine Reference 11756441:1286
Journal J. Biol. Chem
Journal Reference v277 i10 p8741 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/10/8741
Organism mouse
Source Curated
MedLine Reference 11410590:1028
Journal J. Biol. Chem
Journal Reference v276 i34 p31620 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/34/31620
Source Curated
MedLine Reference 11087751:1083
Journal J. Biol. Chem
Journal Reference v276 i7 p5360 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/7/5360
CellLineName Nr8383
Organism rat
Tissue alveola
Source Curated
CellType macrophage
MedLine Reference 10954702:1128
Journal J. Biol. Chem
Journal Reference v275 i47 p37219 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/47/37219
Source Curated
CellType b cell
MedLine Reference 10574951:1217
Journal J. Biol. Chem
Journal Reference v274 i49 p34803 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/49/34803
Organ liver
Source Curated
MedLine Reference 10455158:1061
Journal J. Biol. Chem
Journal Reference v274 i35 p24858 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/35/24858
Organism rat
Source Curated
MedLine Reference 9564854:1043
Journal Endocrinology
Journal Reference v139 i5 p2423 (1998)
Journal Link http://endo.endojournals.org/cgi/content/full/139/5/2423
Organism mouse
Source Curated
CellType osteoblast
MedLine Reference 9501093:1018
Journal EMBO
Journal Reference v17 i6 p1717 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/6/1717
Organism C-elegans
Source Curated
MedLine Reference 11032810:1014
Journal EMBO
Journal Reference v19 i20 p5429 (2000)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/19/20/5429
CellLineName NIH 3T3
Organism C-elegans
Source Curated
Journal J. Neurochem
Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2001.00533.x/full/
CellLineName PC12h
Source Curated
MedLine Reference 9464988:1111
Journal J. Neurosci
Journal Reference v18 i5 p1633 (1998)
Journal Link http://www.jneurosci.org/cgi/content/full/18/5/1633
Organism rat
Tissue microglia
Organ brain
Source Curated
MedLine Reference 10640741:1207
Journal J. Immunol
Journal Reference v164 i3 p1277 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/3/1277
Organism mouse
Tissue microglia
Source Curated
CellType astrocyte
MedLine Reference 9574517:1043
Journal J. Immunol
Journal Reference v160 i9 p4175 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/160/9/4175
Organism mouse
Source Curated
CellType t cell
MedLine Reference 11466342:1134
Journal J. Immunol
Journal Reference v167 i3 p1263 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/167/3/1263
Organism mouse
Source Curated
CellType b cell
MedLine Reference 10092784:1163
Journal J. Immunol
Journal Reference v162 i6 p3316 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/162/6/3316
CellLineName JURKAT
Source Curated
MedLine Reference 8996240:1147
Journal J. Exp. Med
Journal Reference v185 i1 p43 (1997)
Journal Link http://www.jem.org/cgi/content/full/185/1/43
CellLineName H3
Organism mouse
Source Curated
MedLine Reference 10648566:1256
Journal J. Cell Biol
Journal Reference v148 i2 p333 (2000)
Journal Link http://www.jcb.org/cgi/content/full/148/2/333
Organism mouse
Source Curated
CellType osteoclast
MedLine Reference 9278384:1120
Journal J. Biol. Chem
Journal Reference v272 i36 p22381 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/36/22381
Source Curated
CellType platelet
MedLine Reference 9148971:1112
Journal J. Biol. Chem
Journal Reference v272 i20 p13452 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/20/13452
CellLineName ML457
Organism mouse
Source Curated
MedLine Reference 14517212:1047
Journal J. Biol. Chem
Journal Reference v278 i49 p48973 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/49/48973
Organism mouse
Source Curated
MedLine Reference 12149254:1162
Journal J. Biol. Chem
Journal Reference v277 i41 p38205 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/41/38205
CellLineName HCT 116
Source Curated
MedLine Reference 10952974:1170
Journal J. Biol. Chem
Journal Reference v275 i49 p38831 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/49/38831
CellLineName A431
Source Curated
MedLine Reference 9705360:1150
Journal J. Biol. Chem
Journal Reference v273 i34 p22145 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/34/22145
CellLineName NIH 3T3
Organism bovine
Source Curated
MedLine Reference 8940082:1124
Journal J. Biol. Chem
Journal Reference v271 i48 p30950 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/48/30950
CellLineName KB-3
Source Curated
MedLine Reference 8702875:1078
Journal J. Biol. Chem
Journal Reference v271 i35 p21081 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/35/21081
Source Curated
MedLine Reference 10454538:1150
Journal Mol. Cell. Biol
Journal Reference v19 i9 p6003 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/9/6003
Source Curated
CellType hepatocyte
MedLine Reference 9450967:1217
Journal Mol. Biol. Cell
Journal Reference v9 i2 p451 (1998)
Journal Link http://www.molbiolcell.org/cgi/content/full/9/2/451
Organism frog
Source Curated
MedLine Reference 12429824:1187
Journal Mol. Biol. Cell
Journal Reference v13 i11 p3787 (2002)
Journal Link http://www.molbiolcell.org/cgi/content/full/13/11/3787
Organism drosophila
Source Curated
MedLine Reference 10564268:1317
Journal Mol. Biol. Cell
Journal Reference v10 i11 p3729 (1999)
Journal Link http://www.molbiolcell.org/cgi/content/full/10/11/3729
Organism frog
Source Curated
CellType oocyte
MedLine Reference 15231676:4
CellLineName MCF7
Source Curated
MedLine Reference 12493703:13
Organism rat
Source Curated
CellType granulosa
MedLine Reference 10570489:4
Organism rat
Source Curated
CellType neural
MedLine Reference 8892054:7
Source Curated
CellType t cell
MedLine Reference 12364547:1030
Journal Lipid Res
Journal Reference v43 i10 p1630 (2002)
Journal Link http://www.jlr.org/cgi/content/full/43/10/1630
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 10493724:1161
Journal J. Neurosci
Journal Reference v19 i19 p8234 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/19/8234
Organism rat
Source Curated