ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:5747:out-urn:agi-llid:6464::unknown
Entities PTK2 ---> SHC1
References 14
Connectivity 2
Effect unknown
MedLine Reference 11980671:1118
Sentence The latter event is thought to result in the phosphorylation of Shc by FAK and Src (6 , 7) .
Journal Cancer Res
Journal Reference v62 i9 p2699 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/9/2699
Organism mouse
Organ brain
Source Curated
MedLine Reference 8900204:1166
Sentence Focal adhesion kinase (p125 FAK ) is another possible candidate for the tyrosyl kinase that phosphorylates Shc in rat pancreatic acini.
Journal J. Biol. Chem
Journal Reference v271 i43 p27125 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/43/27125
Organism mouse
Organ pancreas
Source Curated
MedLine Reference 9774338:1041
Sentence Direct SH2-mediated binding of Shc to FAK occurs after FN stimulation (Schlaepfer and Hunter, 1997 ) and FAK can directly phosphorylate Shc at Tyr317 to promote Grb2 binding and signaling to ERK2 (Schlaepfer et al ., 1998 ).
Journal EMBO
Journal Reference v17 i20 p5933 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/20/5933
Organism mouse
Source Curated
MedLine Reference 10777511:1047
Sentence Src phosphorylates Tyr-925 in FAK , creating a binding site for Grb2/Sos complex ( 30 , 31 ), which then activates Ras ( 32-35 ). c-Src and FAK may also phosphorylate Shc, which serves as an adaptor protein, recruiting Grb2 ( 33 , 34 ).
Journal J. Biol. Chem
Journal Reference v275 i25 p19382 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/25/19382
Source Curated
MedLine Reference 10915788:1027
Sentence Binding of Src to tyrosine-phosphorylated PYK2 or FAK enhances Src tyrosine kinase activity, which in turn phosphorylates PYK2 and FAK on specific tyrosine residues, and probably also phosphorylates additional signaling molecules such as Shc ( 14 , 15 ).
Journal J. Biol. Chem
Journal Reference v275 i42 p32736 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/42/32736
Source Curated
MedLine Reference 9837978:1334
Journal J. Biol. Chem
Journal Reference v273 i50 p33864 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/50/33864
Organism mouse
Source Curated
MedLine Reference 14617636:8
Tissue endothelial
Source Curated
MedLine Reference 9566877:5
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 11290743:1050
Journal J. Biol. Chem
Journal Reference v276 i28 p26211 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/28/26211
Organism mouse
Source Curated
CellType monocyte
MedLine Reference 12421874:1078
Journal Nutrition
Journal Reference v132 i11 p3482S (1996)
Journal Link http://www.nutrition.org/cgi/content/full/132/11/3482S
Organism plant
Source Curated
MedLine Reference 11333270:1132
Journal J. Biol. Chem
Journal Reference v276 i30 p27757 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/30/27757
Source Curated
MedLine Reference 12221124:1180
Journal Mol. Biol. Cell
Journal Reference v13 i9 p3178 (2002)
Journal Link http://www.molbiolcell.org/cgi/content/full/13/9/3178
Organism mouse
Source Curated
MedLine Reference 11149924:1225
Journal J. Cell Biol
Journal Reference v152 i1 p97 (2001)
Journal Link http://www.jcb.org/cgi/content/full/152/1/97
Organism mouse
Source Curated
MedLine Reference 10613912:1030
Journal J. Cell Biol
Journal Reference v147 i7 p1561 (1999)
Journal Link http://www.jcb.org/cgi/content/full/147/7/1561
Source Curated