Regulation :


Effect	positive
Owner	Public
URN	urn:agi-Regulation:inout-urn:agi-llid:4633:out-urn:agi-cellproc:intergrin clustering::positive
Entities	MYL2 --+> Intergrin clustering
References	1
Connectivity	2


MedLine Reference	14600256
Sentence	Signalling pathways involving ADAP, Vav-1 and SKAP-55, as well as Rap1 and RAPL, cause clustering of leukocyte function-associated antigen-1 (LFA-1; integrin alphaLbeta2). T-cell integrins can also signal, and the pathways dedicated to the migratory activity of T cells have been the most investigated so far. Active LFA-1 causes T-cell attachment and lamellipodial movement induced by myosin light chain kinase at the leading edge, whereas RhoA and ROCK cause T-cell detachment at the trailing edge
Source	Curated