Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:6464:inout-urn:agi-go:0003930:
Entities RAS small monomeric GTPase ---- SHC1
References 24
MedLine Reference 16034442:3
Sentence Fear conditioning resulted in the association of Shc and TrkB, Shc and Ras, the increase in active Ras and phosphorylation of mitogen-activated protein kinase (MAPK).
Tissue amygdala
Organism Rattus norvegicus
MedLine Reference 12417593:10188
Sentence Subsequent interaction with the Shc-Grb2-Sos-Ras complex may then occur as observed in keratinocytes ( 48 ).
Journal J. Biol. Chem
Journal Reference v278 i4 p2199
Journal Link http://www.jbc.org/cgi/content/full/278/4/2199
Organism Mus musculus
MedLine Reference 10187852:10304
Sentence Activation of Ras by many receptors involves tyrosine phosphorylation of the adaptor protein Shc, which recruits the Ras exchange factor SOS to the membrane.
Journal J. Biol. Chem
Journal Reference v274 i15 p10571
Journal Link http://www.jbc.org/cgi/content/full/274/15/10571
MedLine Reference 11390373:10346
Journal J. Biol. Chem
Journal Reference v276 i33 p31422
Journal Link http://www.jbc.org/cgi/content/full/276/33/31422
MedLine Reference 10764815:10286
Journal J. Biol. Chem
Journal Reference v275 i26 p19768
Journal Link http://www.jbc.org/cgi/content/full/275/26/19768
Organism Rattus norvegicus
MedLine Reference 14612490:10168
Journal Cancer Res
Journal Reference v63 i21 p7032
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/21/7032
MedLine Reference 9374504:10165
Journal J. Biol. Chem
Journal Reference v272 i48 p30208
Journal Link http://www.jbc.org/cgi/content/full/272/48/30208
MedLine Reference 9528804:10337
Organism Mus musculus
MedLine Reference 8798782:10120
Journal J. Biol. Chem
Journal Reference v271 i40 p25003
Journal Link http://www.jbc.org/cgi/content/full/271/40/25003
Organism Mus musculus
MedLine Reference 9716598:10204
Journal Blood
Journal Reference v92 i5 p1697
Journal Link http://www.bloodjournal.org/cgi/content/full/92/5/1697
MedLine Reference 10187852:1304
Sentence Activation of Ras by many receptors involves tyrosine phosphorylation of the adaptor protein Shc, which recruits the Ras exchange factor SOS to the membrane.
Journal J. Biol. Chem
Journal Reference v274 i15 p10571 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/15/10571
Source Curated
CellLineName COS-7
MedLine Reference 9716598:1206
Sentence Because Grb2 and Shc are known to interact with the Ras guanine nucleotide exchange factor Sos, we set out to determine whether Sos was also bound to this likely multimolecular complex.
Journal Blood
Journal Reference v92 i5 p1697 (1998)
Journal Link http://www.bloodjournal.org/cgi/content/full/92/5/1697
Source Curated
CellLineName U937IF
MedLine Reference 9312048:1106
Sentence Shc was also shown to be phosphorylated by activated Src kinases (McGlade et al. , 1992 ; Nagai et al. , 1995 ), and was therefore a good candidate for linking Src and Ras activity.
Journal EMBO
Journal Reference v16 i19 p5904 (1997)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/16/19/5904
Organism dog
Source Curated
CellLineName nbt-ii
MedLine Reference 9374504:1165
Sentence As, at this concentration of insulin, the mutant receptors phosphorylate IRS-1 but not Shc, these findings provide support for the notion that insulin signaling to GTP loading of Ras is more closely associated with Shc, rather than IRS-1, phosphorylation.
Journal J. Biol. Chem
Journal Reference v272 i48 p30208 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/48/30208
Source Curated
MedLine Reference 10764815:1286
Sentence The finding that TrkA with the intact Shc-binding site (Y785F/Y751F) induced a significantly lesser phosphorylation of RAFTK than TrkA with the intact p85-binding site (wt or Y785F/Y490F) despite PI3-K activation through the TrkA-Shc- ras complex indicates the important role of p85 in the induction of RAFTK phosphorylation.
Journal J. Biol. Chem
Journal Reference v275 i26 p19768 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/26/19768
Organism rat
Source Curated
MedLine Reference 7525306:1
Source Curated
MedLine Reference 9544989:1023
Journal Mol. Endocrin
Journal Reference v12 i4 p536 (1998)
Journal Link http://mend.endojournals.org/cgi/content/full/12/4/536
Source Curated
MedLine Reference 10964971:1026
Journal J. Neurosci
Journal Reference v20 i17 p6666 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/17/6666
Organism rat
Source Curated
CellLineName PC 12
MedLine Reference 11907067:1287
CellType macrophage
Journal J. Immunol
Journal Reference v168 i7 p3155 (2002)
Journal Link http://www.jimmunol.org/cgi/content/full/168/7/3155
Source Curated
MedLine Reference 9786887:1264
Tissue vascular
Journal J. Biol. Chem
Journal Reference v273 i44 p28860 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/44/28860
Source Curated
CellLineName SMCS
MedLine Reference 8617812:1028
Journal J. Biol. Chem
Journal Reference v271 i9 p5265 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/9/5265
Organism bovine
Source Curated
CellLineName 3T3
MedLine Reference 8798782:1120
CellType t cell
Journal J. Biol. Chem
Journal Reference v271 i40 p25003 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/40/25003
Organism mouse
Source Curated
MedLine Reference 12417593:1189
CellType keratinocyte
Journal J. Biol. Chem
Journal Reference v278 i4 p2199 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/4/2199
Source Curated
MedLine Reference 11390373:1346
Journal J. Biol. Chem
Journal Reference v276 i33 p31422 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/33/31422
Source Curated
CellLineName HepG 2