Protein : MAP2K4


Owner	Public
URN	urn:agi-llid:6416
Hugo ID	6844
Connectivity	536
Name	MAP2K4
Description	mitogen activated protein kinase kinase 4
Notes	This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.


RGD ID	1307040


MGI ID	1346869


Pathway	Jnk-mapk
	p38 MAPK
	FAS signaling
	EGF signaling
	p38 Signaling
	PDGF signaling
	TNFR1 signaling
	SAPK-JNK Signaling
	Toll-Like Receptor pathway
	MAPK signaling
	TNFRSF6 -> DDIT3 signaling pathway
	EDG3/5 -> AP-1 signaling pathway
	TNFRSF6 -> HSF1 signaling pathway
	EDG3/5 -> ELK1-SRF signaling pathway
	EDG3/5 -> ELK4-SRF signaling pathway
	EGFR -> AP-1 signaling pathway
	NTRK1 -> SMAD3 signaling pathway
	NTRKs -> AP-1 signaling pathway
	NTRKs -> ELK1-SRF signaling pathway
	NTRKs -> ELK4-SRF signaling pathway
	EGFR -> ATF2 signaling pathway
	NTRKs -> MYC signaling pathway
	NTRKs -> TP53 signaling pathway
	ERBB2/3 -> SP1 signaling pathway
	EGFR/ERBB2 -> TP53 signaling pathway
	F2R -> AP-1 signaling pathway
	ENDRA -> AP-1 signaling pathway
	RET -> HSF1 signaling pathway
	ENDRA -> CREB1 signaling pathway
	ENDRB -> AP-1 signaling pathway
	F2R -> CREB1 signaling pathway
	ENDRB -> CREB1 signaling pathway
	ENDRB -> ELK1-SRF signaling pathway
	F2R -> ELK1-SRF signaling pathway
	ENDRB -> ELK4-SRF signaling pathway
	F2R -> ELK4-SRF signaling pathway
	PTAFR -> AP-1 signaling pathway
	PTAFR -> ATF1 signaling pathway
	PTAFR -> ELK1-SRF signaling pathway
	PTAFR -> ELK4-SRF signaling pathway
	IL1R -> STAT3 signaling pathway
	ERBB2 -> ETS2 signaling pathway
	ERBB2 -> ETV1 signaling pathway
	CD28 -> ATF1 signaling pathway
	CD28 -> ATF2 signaling pathway
	CD28 -> CREB1 signaling pathway
	TGFBR -> AP-1 signaling pathway
	Frizzled -> JUN signaling pathway
	CD28 -> NF-kB signaling pathway
	TGFBR -> ATF2 signaling pathway
	TGFBR -> CREB1 signaling pathway
	TGFBR -> ELK1-SRF signaling pathway
	Frizzled -> PAX2 signaling pathway
	TGFBR -> ELK4-SRF signaling pathway
	TGFBR -> GADD153 signaling pathway
	TGFBR -> MAX signaling pathway
	TGFBR -> MEF2A signaling pathway
	TGFBR -> MEF2C signaling pathway
	TGFBR -> TP53 signaling pathway
	ITGB1 -> AP-1 signaling pathway
	TLR2/4/5/7/9 -> AP-1 signaling pathway
	ITGB1 -> ELK1-SRF signaling pathway
	ITGB1 -> ELK4-SRF signaling pathway
	ITGB1 -> NF-kB signaling pathway
	KDR -> ATF1 signaling pathway
	GFRs -> AP-1 signaling pathway
	GFRs -> CREB1 signaling pathway
	GFRs -> ELK1-SRF signaling pathway
	KDR -> ATF2 signaling pathway
	GFRs -> ELK4-SRF signaling pathway
	KDR -> CREB1 signaling pathway
	TLR2/6 -> AP-1 signaling pathway
	GFRs -> MYC signaling pathway
	KDR -> ELK1-SRF signaling pathway
	KDR -> ELK4-SRF signaling pathway
	TNFRs -> AP-1 signaling pathway
	GNRHR -> ELK1-SRF signaling pathway
	GNRHR -> ELK4-SRF signaling pathway
	MPL -> SPI1 signaling pathway
	TNFRs -> ATF2 signaling pathway
	TNFRs -> ELK1-SRF signaling pathway
	TNFRs -> ELK4-SRF signaling pathway
	NGFR -> AP-1 signaling pathway
	TNFRs -> TP53 signaling pathway
	TNFRSF1A -> AP-1 signaling pathway
	TNFRSF1A -> ATF2 signaling pathway
	DRD2 -> AP-1 signaling pathway
	TNFRSF1A -> ELK1-SRF signaling pathway
	NGFR -> ELK1-SRF signaling pathway
	TNFRSF1A -> ELK4-SRF signaling pathway
	NGFR -> ELK4-SRF signaling pathway
	NGFR -> TP53 signaling pathway
	DRD2 -> ELK1-SRF signaling pathway
	TNFRSF1A -> TP53 signaling pathway
	DRD2 -> ELK4-SRF signaling pathway
	EDARs -> AP-1 signaling pathway


Group	Kinases
	signal transduction
	MAPKKK cascade
	JNK cascade
	protein amino acid phosphorylation
	nucleotide binding
	protein binding
	ATP binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity


GenBank ID	NC_000017
	NM_003010
	NP_003001
	NT_010718
	NW_926584
	AC_000060
	AC005244
	AC005410
	AF070082
	AAC24130
	AF070085
	AF070088
	AF070090
	DQ015703
	AAY22176
	AA293365
	AK122997
	AK131544
	BC036032
	AAH36032
	BC050386
	BC060764
	AAH60764
	BT019676
	AAV38482
	CR536564
	CAG38801
	L31902
	L36870
	AAC41719
	U17743
	AAC50127
	P45985
	Q5U0B8
	Q6FHX4
	Q6P9H2
	Q6PIE6
	NC_000077
	NM_009157
	NP_033183
	NT_096135
	NW_000039
	NW_001030477
	AC_000033
	AL662895
	AL663069
	AK036928
	BAC29642
	AK044534
	BAC31968
	AK044698
	BAC32038
	AK139777
	AK187893
	BC029833
	AAH29833
	BM240207
	U18310
	AAB81554
	P47809
	Q543X6
	NC_005109
	NM_001030023
	NP_001025194
	NW_001084656
	NW_047334
	AC_000078
	AY880882
	AAX61181


Source	Curated


LocusLink ID	6416
	26398
	287398


Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus


OMIM ID	601335


Alias	JNKK
	MEK4
	MKK4
	SEK1
	JNKK1
	SERK1
	MAPKK4
	PRKMK4
	mitogen-activated protein kinase kinase 4
	MAPK/ERK kinase 4
	SAPK/ERK kinase 1
	MAP kinase kinase 4
	JNK-activated kinase 1
	JNK activating kinase 1
	c-Jun N-terminal kinase kinase 1
	dual specificity mitogen-activated protein kinase kinase 4
	mitogen activated protein kinase kinase 4
	SAPK/Erk/kinase 1
	dual specificity mitogen-activated protein kinase kinase 4


GO ID	0005524
	0000166
	0005515
	0004674
	0004713
	0016740
	0007254
	0006468
	0007165
	0016301
	0004672
	0000165


Swiss-Prot Accession	P45985
	Q5U0B8
	Q6FHX4
	Q6P9H2
	Q6PIE6
	P47809
	Q543X6


Unigene ID	Hs.514681
	Mm.27491
	Rn.19653