Protein : EGF


Owner	Public
URN	urn:agi-llid:1950
Hugo ID	3229
Connectivity	3323
Name	EGF
Description	epidermal growth factor
Notes	binds the epidermal growth factor receptor; may play a role in MAP kinase mediated signaling pathways [RGD]


RGD ID	2542


MGI ID	95290


Cell Localization	Extracellular


Pathway	EGF signaling
	EGF
	EGFR -> AP-1 signaling pathway
	ERBB2 -> ETV4 signaling pathway
	EGFR -> ATF2 signaling pathway
	EGFR -> CTNND1 signaling pathway
	EGFR -> SMAD1 signaling pathway
	EGFR -> ZNF259 signaling pathway
	EGFR/ERBB2 -> CTNNB1 signaling pathway
	EGFR/ERBB2 -> HIF1A signaling pathway
	EGFR/ERBB2 -> STAT1 signaling pathway
	EGFR/ERBB2 -> STAT3 signaling pathway
	EGFR/ERBB2 -> STAT5A signaling pathway
	EGFR/ERBB2 -> STAT5B signaling pathway
	EGFR/ERBB2 -> TP53 signaling pathway
	EGFR/ERBB3 -> MEF2A signaling pathway
	EGFR/ERBB3 -> MEF2C signaling pathway
	EGFR/ERBB4 -> STAT5A signaling pathway
	EGFR/ERBB4 -> STAT5B signaling pathway
	ERBB2 -> EP300 signaling pathway
	ERBB2 -> ETS1 signaling pathway
	ERBB2 -> ETS2 signaling pathway
	ERBB2 -> ETV1 signaling pathway
	Aquaporin


Group	Ligands
	epidermal growth factor receptor signaling pathway
	protein kinase cascade
	activation of MAPK activity
	activation of MAPKK activity
	chromosome organization and biogenesis (sensu Eukaryota)
	positive regulation of cell proliferation
	regulation of peptidyl-tyrosine phosphorylation
	peptidyl-tyrosine phosphorylation
	DNA replication
	branching morphogenesis of a tube
	regulation of protein secretion
	extracellular region
	membrane
	nucleus
	plasma membrane
	integral to membrane
	extracellular space
	protein binding
	calcium ion binding
	epidermal growth factor receptor binding
	growth factor activity
	epidermal growth factor receptor activating ligand activity


Source	Curated


OMIM ID	131530


Alias	URG
	epidermal growth factor (beta-urogastrone)
	urogastrone
	AI790464
	epidermal growth factor


MedScan ID	1950


LocatorString	pmquery:aquaporin