Protein : SHC1
Owner Public
URN urn:agi-llid:6464
Hugo ID 10840
Connectivity 986
Name SHC1
Description src homology 2 domain-containing transforming protein C1
Notes mouse homolog interacts with growth factor receptors; involved in transformation and differentiation in a Ras-dependent fashion [RGD]
RGD ID 620446
MGI ID 98296
Pathway HGF
Insulin Receptor Signaling
Neurotensin
Antiapoptotic Pathways From IGF-1R
Insulin pathway
EGF signaling
EPHB1
PDGFRB
p38 Signaling
PDGF signaling
opioids OPRD1
MAPK-ERK in Growth and Differentiation
Erythropoietin signaling
IL-6 signaling
G-protein Coupled Receptor signaling
Bombesin
Oxytocin
PTEN signaling
SAPK-JNK Signaling
IL-3 signaling
Vasopressin
IL-2 signaling
Cholecystokinin
Gastrin
Substance P
NGF signaling
Erk-PI3K in Collagen Binding
Endothelin
IL-1 and IL-6 signaling
EGF
Integrin Signaling
Nociceptin
EDG2 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
NTRK1 -> SMAD3 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
ERBB2 -> ETV4 signaling pathway
EGFR -> ATF2 signaling pathway
EGFR -> CTNND1 signaling pathway
EGFR -> SMAD1 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
EGFR/ERBB2 -> CTNNB1 signaling pathway
NTRKs -> TP53 signaling pathway
IGF1R -> ELK1-SRF signaling pathway
EGFR/ERBB2 -> HIF1A signaling pathway
ERBB2/3 -> SP1 signaling pathway
IGF1R -> ELK4-SRF signaling pathway
IGF1R -> HIF1A signaling pathway
IGF1R -> MYC signaling pathway
IGF1R -> SREBF1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
F2R -> AP-1 signaling pathway
EGFR/ERBB4 -> STAT5A signaling pathway
EGFR/ERBB4 -> STAT5B signaling pathway
PLAUR -> ELK1-SRF signaling pathway
RET -> HSF1 signaling pathway
PLAUR -> ELK4-SRF signaling pathway
F2R -> CREB1 signaling pathway
F2R -> ELK1-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
F2R -> SP1 signaling pathway
EPOR -> FOS signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
ERBB2 -> EP300 signaling pathway
ERBB2 -> ETS1 signaling pathway
ERBB2 -> ETS2 signaling pathway
ERBB2 -> ETV1 signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL2R -> MYC signaling pathway
IL4R -> ELK1-SRF signaling pathway
IL4R -> ELK4-SRF signaling pathway
IL4R -> HMGY signaling pathway
FGFRs -> RUNX2 signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
INSR -> SREBF1 signaling pathway
INSR -> SREBF2 signaling pathway
ITGB1 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
ITGB1 -> SREBF2 signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
GFRs -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
GFRs -> NCOR2 signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KDR -> NFATC1 signaling pathway
KIT -> MITF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
GHR -> MYC signaling pathway
GRM1/5 -> CREB1 signaling pathway
MPL -> CREB1 signaling pathway
MPL -> SP1 signaling pathway
MPL -> SPI1 signaling pathway
DDR1 -> NF-kB signaling pathway
DRD2 -> AP-1 signaling pathway
DRD2 -> CREB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Group Ph
Sh2
intracellular signaling cascade
regulation of epidermal growth factor receptor activity
activation of MAPK activity
positive regulation of mitosis
regulation of cell growth
actin cytoskeleton organization and biogenesis
positive regulation of cell proliferation
positive regulation of smooth muscle cell proliferation
plasma membrane
protein binding
phospholipid binding
insulin receptor binding
insulin-like growth factor receptor binding
transmembrane receptor protein tyrosine kinase adaptor protein activity
GenBank ID NC_000001
NM_003029
NP_003020
NM_183001
NP_892113
NT_004487
NW_925683
AC_000044
AF455141
AAM61859
AAM61860
AL451085
CAI13246
CAI13247
CAI13248
CAI13249
CAI13250
CAI13251
CAI13252
CAI13253
CAI13254
Y09847
CAA70977
AB208849
BAD92086
AK096169
AK130014
BC011813
BC014158
AAH14158
BC017283
BC033925
AAH33925
BX647136
BX647149
U73377
AAB49972
X68148
CAA48251
P29353
Q59HB0
Q5T180
Q5T181
Q5T182
Q5T183
Q5T184
Q5T185
Q5T186
Q5T187
Q5T188
Q8NFT0
Q8NFT1
NC_000069
NM_011368
NP_035498
NT_039240
NW_000191
NW_001030721
AC_000025
AC171273
AF455140
U46956
AAA91777
AI050321
AK036980
AK049357
BAC33706
AK155158
BAE33083
AK191292
AK195313
AK199216
AK203451
AK205229
AK211173
BB753533
BC036172
AAH36172
BG070010
BG082870
BG088317
U15784
AAC52146
P98083
NC_005101
NM_053517
NP_445969
NW_001084805
NW_047626
AC_000070
BC088298
AAH88298
D83015
BAA74950
Q5M824
Q9Z1I0
Source Curated
LocusLink ID 6464
20416
85385
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 600560
Alias SHC
p66
SHCA
p52SHC
p66SHC
FLJ26504
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain-containing) transforming protein 1
src homology 2 domain-containing transforming protein C
src homology 2 domain-containing transforming protein C1
GO ID 0005158
0005159
0005543
0005515
0005068
0000187
0007242
0008284
0045840
0001558
0007176
0005886
0030036
0048661
Swiss-Prot Accession P29353
Q59HB0
Q5T180
Q5T181
Q5T182
Q5T183
Q5T184
Q5T185
Q5T186
Q5T187
Q5T188
Q8NFT0
Q8NFT1
P98083
Q5M824
Q9Z1I0
Unigene ID Hs.433795
Mm.86595
Rn.138818