Protein : EGFR
Owner Public
URN urn:agi-llid:1956
Hugo ID 3236
Connectivity 2931
Name EGFR
Description epidermal growth factor receptor
Notes promotes cell proliferation and differentiation; mediates GPCR regulated induction of protein synthesis [RGD]
RGD ID 2543
MGI ID 95294
Cell Localization Plasma membrane
Pathway Neurotensin
EGF signaling
Bombesin
Vasopressin
Substance P
Endothelin
EGF
EDG2 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
EGFR -> ATF2 signaling pathway
EGFR -> CTNND1 signaling pathway
EGFR -> SMAD1 signaling pathway
EGFR -> ZNF259 signaling pathway
EGFR/ERBB2 -> CTNNB1 signaling pathway
EGFR/ERBB2 -> HIF1A signaling pathway
EGFR/ERBB2 -> STAT1 signaling pathway
EGFR/ERBB2 -> STAT3 signaling pathway
EGFR/ERBB2 -> STAT5A signaling pathway
EGFR/ERBB2 -> STAT5B signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
EGFR/ERBB3 -> MEF2A signaling pathway
F2R -> AP-1 signaling pathway
EGFR/ERBB3 -> MEF2C signaling pathway
EGFR/ERBB4 -> STAT5A signaling pathway
EGFR/ERBB4 -> STAT5B signaling pathway
F2R -> CREB1 signaling pathway
F2R -> ELK1-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
F2R -> NF-kB signaling pathway
F2R -> SP1 signaling pathway
CHRM1 -> CREB1 signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
GRM1/5 -> CREB1 signaling pathway
DRD2 -> AP-1 signaling pathway
DRD2 -> CREB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
DRD2 -> ELK4-SRF signaling pathway
DRD2 -> NF-kB signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Aquaporin
Group Kinases
Receptors
cell-cell adhesion
signal transduction
cell surface receptor linked signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
phospholipase C activation
protein kinase cascade
calcium-dependent phospholipase A2 activation
cell cycle
cell proliferation
negative regulation of progression through cell cycle
positive regulation of cell migration
cell morphogenesis
protein insertion into membrane
positive regulation of epithelial cell proliferation
positive regulation of cell proliferation
regulation of peptidyl-tyrosine phosphorylation
protein biosynthesis
protein amino acid phosphorylation
protein amino acid autophosphorylation
electron transport
positive regulation of phosphorylation
ossification
positive regulation of nitric oxide biosynthesis
positive regulation of MAPK activity
regulation of nitric-oxide synthase activity
response to stress
intracellular
membrane
cytoplasm
endosome
endocytic vesicle
AP-2 adaptor complex
nucleus
cytoskeleton
plasma membrane
integral to membrane
integral to plasma membrane
basolateral plasma membrane
extracellular space
signal transducer activity
nucleotide binding
protein binding
iron ion binding
double-stranded DNA binding
ATP binding
actin filament binding
protein heterodimerization activity
transferase activity
electron carrier activity
kinase activity
protein kinase activity
protein-tyrosine kinase activity
MAP-ERK kinase kinase activity
transmembrane receptor protein tyrosine kinase activity
epidermal growth factor receptor activity
nitric-oxide synthase regulator activity
receptor activity
transmembrane receptor activity
GenBank ID NC_000007
NM_005228
NP_005219
NM_201284
NP_958441
NM_201282
NP_958439
NM_201283
NP_958440
NT_033968
NT_079592
NW_923284
AC_000050
AC_000068
AC006977
AC073324
AAS07524
AF125539
AAG43243
AAG43244
AF288738
AAG35786
AAG35787
AAG35788
AAG35789
AAG35790
AY588246
AAS83109
CH236957
CS238505
CAJ55813
M11234
AAA52370
M38425
AAA63171
U48723
AAC50803
AAC50804
U48724
AAC50796
U48725
AAC50797
U48726
AAC50798
U48727
AAC50799
U48728
AAC50800
U48729
AAC50801
X06370
CAA29668
AB209442
BAD92679
AF125253
AAG43240
AF277897
AAK01080
AI217671
AL598260
AU137334
AW163038
AW295229
AY550966
AAT52212
AY698023
AAT97978
AY698024
AAT97979
BC070081
BC094761
AAH94761
BC118665
AAI18666
CB160831
K03193
AAA52371
U48722
AAC50802
U95089
AAB53063
X00588
CAA25240
X00663
CAA25282
P00533
Q504U8
Q59FL8
Q68GS5
Q68GS6
Q75MF2
Q8WZA5
Q9H3C8
NC_000077
NM_207655
NP_997538
NM_007912
NP_031938
NT_039515
NW_000035
NW_001030444
AC_000033
AF125256
AAG43241
AF275364
AAG28045
AF275365
AF275366
AAG28046
AAG28047
AF456454
AAL56615
AL645532
CAI24997
CAI24998
CAI24999
BX255277
CAI35983
CAI35984
S50852
S50853
S50854
S50855
AF124513
AAD44149
AF275367
AAG24386
AF277898
AAK01081
AI552599
AK004883
BAB23641
AK004911
BAB23662
AK004944
BAB23688
AK014017
AK033431
AK049452
AK134262
AK163338
BAE37306
AV369812
AW045512
BC023729
AAH23729
BC030681
BQ553815
BY725722
L06864
AAA53029
U03425
AAA17899
X59698
CAA42219
X78987
CAA55587
Z12608
CAA78249
Q01279
Q5SVE7
Q5SVE8
NC_005113
NM_031507
NP_113695
NW_001084695
NW_047430
AC_000082
AB025197
BAA76391
AF142153
AAF27540
AF187818
AAG17037
M37394
AAF14008
U52529
AAC53049
Q62954
Source Curated
LocusLink ID 1956
13649
24329
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 131550
211980
Alias ERBB
mENA
ERBB1
epidermal growth factor receptor
cell growth inhibiting protein 40
truncated epidermal growth factor receptor
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Wa5
wa2
Errp
wa-2
AI552599
9030024J15Rik
RP23-295E4.1
waved 2
ErbB-1
EGFR-related peptide
avian erythroblastic leukemia viral (v-erbB) oncogene homolog
Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
GO ID 0005524
0004710
0051015
0003690
0005006
0030235
0000166
0005515
0046982
0016740
0004888
0043006
0007049
0008283
0007166
0016337
0007173
0045786
0001503
0007202
0043406
0030335
0050679
0045429
0042327
0006468
0051205
0050999
0050730
0006950
0030122
0005737
0005768
0005615
0016021
0005634
0005886
0009055
0005506
0016301
0004672
0004713
0004872
0004871
0004714
0000902
0006118
0008284
0046777
0007165
0007169
0016323
0005856
0030139
0005887
0005622
0016020
0006412
0007243
Swiss-Prot Accession P00533
Q504U8
Q59FL8
Q68GS5
Q68GS6
Q75MF2
Q8WZA5
Q9H3C8
Q01279
Q5SVE7
Q5SVE8
Q62954
MedScan ID 1956
Unigene ID Hs.488293
Mm.8534
Rn.37227
LocatorString pmquery:aquaporin