ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:4214:out-urn:agi-llid:6416::positive
Entities MAP3K1 --+> MAP2K4
References 152
Connectivity 2
Effect positive
MedLine Reference 10924086:1131
Sentence MEKK1, in turn, can phosphorylate several downstream kinases including SEK1 (Davis 2000 ; Fig. 3 A).
Journal Heart Circul
Journal Reference v279 i2 pH852 (2000)
Journal Link http://ajpheart.physiology.org/cgi/content/full/279/2/H852
Organism dog
Source Curated
CellType keratinocyte
MedLine Reference 9808624:1097
Sentence We also examined the ability of MEKK1 to phosphorylate two JNKK1 deletion mutants lacking its first 77 or 88 amino acids.
Journal Genes & Dev
Journal Reference v12 i21 p3369 (1998)
Journal Link http://www.genesdev.org/cgi/content/full/12/21/3369
Source Curated
MedLine Reference 12796506:1039
Sentence Mitogen-activated protein kinase kinase kinase (MEKK1) (also known as JNK kinase kinase) can activate the JNK upstream regulators SEK1/MKK4 and MKK7 ( 29 ).
Journal J. Biol. Chem
Journal Reference v278 i33 p30711 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/33/30711
Source Curated
MedLine Reference 12024021:1284
Sentence For example, while MEKK1 can activate only SEK1 and MKK7 ( 44 ) and TAO can activate only MKK3 ( 10 ), MEKK3 can activate both Jnk- and p38-activating kinases ( 2 , 14 , 17 ).
Journal Mol. Cell. Biol
Journal Reference v22 i12 p4073 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/12/4073
Organism Rattus norvegicus
Source Curated
MedLine Reference 10064598:1303
Sentence The ability of GSTp to block JNK activity in spite of MKK4 and JNK phosphorylation by MEKK1 suggests that the nature of the GST-JNK association disables JNK activity as a kinase.
Journal EMBO
Journal Reference v18 i5 p1321 (1999)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/18/5/1321
Organism mouse
Source Curated
MedLine Reference 9405400:1130
Sentence Since the C-terminal half of MEKK1 also binds to MEK4/SEK1, 2 it will be interesting to investigate whether the three kinases in the MAP kinase module form a complex simultaneously.
Source Curated
MedLine Reference 10713157:1087
Sentence Under the same conditions, however, the patterns of JNKK1 activation by MEKK1(CT) and MEKK2(CT) were reversed: MEKK2(CT) was a less effective activator of JNKK1 than was MEKK1(CT) (Fig. 1 B).
Journal Mol. Cell. Biol
Journal Reference v20 i7 p2334 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/7/2334
Source Curated
MedLine Reference 12438272:1159
Sentence MEKK1, which is known to phosphorylate MKK4 in response to cellular stimuli, was expressed in all four of the cell lines as were the MAP kinases JNK1, JNK2, and p38, and the transcription factor, c-jun.
Journal Cancer Res
Journal Reference v62 i22 p6717 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/22/6717
Organism mouse
Source Curated
MedLine Reference 9756505:1035
Sentence In response to a broad variety of extracellular signals, the serine-threonine protein kinase MAPK/ERK kinase kinase 1 (MEKK1) is activated, leading to the phosphorylation of the c-Jun NH2-terminal kinase kinase 1 (JNKK1), a dual-specificity kinase that activates and phosphorylates the JNKs.
Journal Gastr. Liver Phys
Journal Reference v275 i4 pG740 (1998)
Journal Link http://ajpgi.physiology.org/cgi/content/full/275/4/G740
Organ gastric
Source Curated
MedLine Reference 9687508:1174
Sentence In the JNK signalling pathway, MEKK1 phosphorylates and activates SEK1, also called MKK4, which in turn activates JNK by phosphorylating its regulatory Tyr and Thr residues (Lange-Carter et al. , 1993 ; D???©rijard et al. , 1994 ; Kyriakis et al. , 1994 ; S????nchez et al. , 1994 ; Yan et al. , 1994 ; Lin et al. , 1995 ).
Journal EMBO
Journal Reference v17 i15 p4404 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/15/4404
CellLineName PC 12
Organism rat
Source Curated
CellType neural
MedLine Reference 10521505:1123
Journal J. Biol. Chem
Journal Reference v274 i43 p31055 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/43/31055
CellLineName COS I
Source Curated
MedLine Reference 9705357:1028
Journal J. Biol. Chem
Journal Reference v273 i34 p22120 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/34/22120
Organism rat
Source Curated
MedLine Reference 9162092:1043
Journal J. Biol. Chem
Journal Reference v272 i22 p14489 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/22/14489
CellLineName PC 12
Organ brain
Source Curated
CellType myocyte
MedLine Reference 9065412:1290
Journal J. Biol. Chem
Journal Reference v272 i12 p7586 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/12/7586
Organism mouse
Source Curated
MedLine Reference 8662753:1148
Journal J. Biol. Chem
Journal Reference v271 i22 p13234 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/22/13234
Organism mouse
Source Curated
MedLine Reference 14500727:1013
Journal J. Biol. Chem
Journal Reference v278 i48 p48498 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/48/48498
Organism mouse
Source Curated
MedLine Reference 12456688:1104
Journal J. Biol. Chem
Journal Reference v278 i3 p1403 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/3/1403
CellLineName HEK 293
Organism plant
Source Curated
MedLine Reference 11700324:1038
Journal J. Biol. Chem
Journal Reference v277 i2 p1217 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/2/1217
Organ kidney
Source Curated
MedLine Reference 10969079:1247
Journal J. Biol. Chem
Journal Reference v275 i51 p40120 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/51/40120
Source Curated
MedLine Reference 10871633:1108
Journal J. Biol. Chem
Journal Reference v275 i37 p28858 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/37/28858
CellLineName HepG 2
Source Curated
MedLine Reference 9556577:1197
Journal J. Biol. Chem
Journal Reference v273 i18 p10979 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/18/10979
Organism mouse
Source Curated
CellType MAST
MedLine Reference 9535930:1293
Journal J. Biol. Chem
Journal Reference v273 i15 p9344 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/15/9344
Organism C-elegans
Tissue marrow
Source Curated
CellType macrophage
MedLine Reference 9516438:1192
Journal J. Biol. Chem
Journal Reference v273 i13 p7406 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/13/7406
CellLineName ES
Source Curated
MedLine Reference 9405446:1130
Journal J. Biol. Chem
Journal Reference v272 i51 p32378 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/51/32378
CellLineName 293T
Organism mouse
Source Curated
MedLine Reference 9312068:1115
Journal J. Biol. Chem
Journal Reference v272 i40 p24751 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/40/24751
Source Curated
MedLine Reference 9201973:1071
Journal J. Biol. Chem
Journal Reference v272 i27 p16725 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/27/16725
CellLineName N18
Source Curated
MedLine Reference 9195981:1127
Journal J. Biol. Chem
Journal Reference v272 i26 p16657 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/26/16657
Organism rat
Organ heart
Source Curated
MedLine Reference 8621542:1024
Journal J. Biol. Chem
Journal Reference v271 i15 p8971 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/15/8971
Organism yeast
Source Curated
MedLine Reference 9006895:1107
Journal J. Biol. Chem
Journal Reference v272 i5 p2620 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/5/2620
CellLineName 293
Organism mouse
Source Curated
MedLine Reference 8798679:1060
Journal J. Biol. Chem
Journal Reference v271 i40 p24313 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/40/24313
Source Curated
MedLine Reference 7721728:1026
Journal J. Biol. Chem
Journal Reference v270 i15 p8377 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/15/8377
Organism rat
Source Curated
MedLine Reference 11707464:1029
Journal J. Biol. Chem
Journal Reference v277 i4 p2573 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/4/2573
Source Curated
MedLine Reference 11477069:1032
Journal J. Biol. Chem
Journal Reference v276 i39 p36797 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/39/36797
Organism dog
Tissue bone
Source Curated
MedLine Reference 11278263:1163
Journal J. Biol. Chem
Journal Reference v276 i19 p16406 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/19/16406
CellLineName SW 480
Organism mouse
Source Curated
MedLine Reference 11063742:1053
Journal J. Biol. Chem
Journal Reference v276 i7 p4662 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/7/4662
Source Curated
MedLine Reference 10801798:1171
Journal J. Biol. Chem
Journal Reference v275 i27 p20533 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/27/20533
CellLineName HEK 293
Organism mouse
Source Curated
Journal Cell
Journal Reference v88 i2 p213 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/2/213
CellLineName HeLa
Source Curated
MedLine Reference 11053415:1059
Journal J. Biol. Chem
Journal Reference v276 i3 p2189 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/3/2189
Source Curated
CellType neutrophil
MedLine Reference 10644709:1031
Journal J. Biol. Chem
Journal Reference v275 i4 p2527 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/4/2527
Source Curated
MedLine Reference 10318790:1028
Journal J. Biol. Chem
Journal Reference v274 i20 p13841 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/20/13841
Organism mouse
Source Curated
MedLine Reference 11784851:1167
Journal Mol. Cell. Biol
Journal Reference v22 i3 p737 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/3/737
Organism rat
Source Curated
MedLine Reference 12024020:1284
Journal Mol. Cell. Biol
Journal Reference v22 i12 p4073 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/12/4073
Organism mouse
Source Curated
MedLine Reference 10523665:1358
Journal Mol. Cell. Biol
Journal Reference v19 i11 p7759 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/11/7759
CellLineName NIH 3T3
Organism mouse
Source Curated
MedLine Reference 10373563:1037
Journal Mol. Cell. Biol
Journal Reference v19 i7 p5143 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/7/5143
Organism mouse
Source Curated
MedLine Reference 10866655:5
Organism mouse
Source Curated
MedLine Reference 9576928:1
Organism mouse
Source Curated
MedLine Reference 9464996:1301
Journal J. Neurosci
Journal Reference v18 i5 p1713 (1998)
Journal Link http://www.jneurosci.org/cgi/content/full/18/5/1713
Organism rat
Source Curated
CellType neural
MedLine Reference 11035054:1022
Journal J. Immunol
Journal Reference v165 i8 p4217 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/165/8/4217
Source Curated
CellType t cell
MedLine Reference 9607917:1126
Journal J. Exp. Med
Journal Reference v187 i11 p1753 (1998)
Journal Link http://www.jem.org/cgi/content/full/187/11/1753
CellLineName RAJI
Source Curated
MedLine Reference 9733728:1188
Journal J. Biol. Chem
Journal Reference v273 i38 p24387 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/38/24387
Source Curated
CellType keratinocyte
MedLine Reference 9603971:1242
Journal J. Biol. Chem
Journal Reference v273 i23 p14560 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/23/14560
CellLineName SH-SY5Y
Source Curated
MedLine Reference 9582321:1016
Journal J. Biol. Chem
Journal Reference v273 i21 p12901 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/21/12901
Organism mouse
Source Curated
MedLine Reference 10713154:1117
Journal Mol. Cell. Biol
Journal Reference v20 i7 p2334 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/7/2334
Source Curated
MedLine Reference 10082519:1123
Journal Mol. Cell. Biol
Journal Reference v19 i4 p2547 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/4/2547
Organism yeast
Source Curated
MedLine Reference 7997270:5
CellLineName NIH 3T3
Organism mouse
Source Curated
MedLine Reference 11331298:1080
Journal J. Cell Biol
Journal Reference v153 i3 p457 (2001)
Journal Link http://www.jcb.org/cgi/content/full/153/3/457
CellLineName HEK 293
Organism mouse
Source Curated
MedLine Reference 9890973:1030
Journal J. Biol. Chem
Journal Reference v274 i4 p2118 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/4/2118
Organism yeast
Source Curated
CellType lymphocyte
MedLine Reference 9295340:1268
Journal J. Biol. Chem
Journal Reference v272 i38 p23905 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/38/23905
CellLineName COS-7
Source Curated
MedLine Reference 9006914:1052
Journal J. Biol. Chem
Journal Reference v272 i5 p2753 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/5/2753
Source Curated
MedLine Reference 9325285:1025
Journal J. Biol. Chem
Journal Reference v272 i41 p25636 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/41/25636
Organism rat
Tissue skeletal muscle
Source Curated
MedLine Reference 8939929:1096
Journal J. Biol. Chem
Journal Reference v271 i47 p29876 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/47/29876
CellLineName NIH 3T3
Organism mouse
Source Curated
CellType lymphocyte
MedLine Reference 8702835:1145
Journal J. Biol. Chem
Journal Reference v271 i34 p20805 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/34/20805
Organism rat
Tissue smooth muscle
Source Curated
CellType fibroblast
MedLine Reference 8621675:1177
Journal J. Biol. Chem
Journal Reference v271 i6 p2886 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/6/2886
CellLineName COS-7
Source Curated
MedLine Reference 7629196:1166
Journal J. Biol. Chem
Journal Reference v270 i31 p18655 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/31/18655
Organism mouse
Source Curated
MedLine Reference 12186863:1181
Journal J. Biol. Chem
Journal Reference v277 i43 p40687 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/43/40687
Source Curated
CellType neutrophil
MedLine Reference 11733514:1153
Journal J. Biol. Chem
Journal Reference v277 i6 p4110 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/6/4110
CellLineName PC 12
Organism rat
Source Curated
MedLine Reference 11402042:1207
Journal J. Biol. Chem
Journal Reference v276 i33 p30708 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/33/30708
Source Curated
CellType hepatocyte
MedLine Reference 11278389:1037
Journal J. Biol. Chem
Journal Reference v276 i19 p16310 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/19/16310
CellLineName F9
Organism C-elegans
Source Curated
Journal Cell
Journal Reference v88 i2 p213 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/2/213
CellLineName HeLa
Source Curated
MedLine Reference 11278353:1250
Journal J. Biol. Chem
Journal Reference v276 i24 p21004 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/24/21004
Source Curated
MedLine Reference 11278340:1300
Journal J. Biol. Chem
Journal Reference v276 i21 p18130 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/21/18130
Source Curated
MedLine Reference 11121427:1122
Journal J. Biol. Chem
Journal Reference v276 i12 p8836 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/12/8836
CellLineName RAW264.7
Organism mouse
Source Curated
MedLine Reference 11042219:1028
Journal J. Biol. Chem
Journal Reference v275 i52 p41000 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/52/41000
Source Curated
MedLine Reference 10531374:1039
Journal J. Biol. Chem
Journal Reference v274 i44 p31655 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/44/31655
Organ gastric
Source Curated
MedLine Reference 10347227:1175
Journal J. Biol. Chem
Journal Reference v274 i23 p16604 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/23/16604
Source Curated
MedLine Reference 11956171:1158
Journal Endocrinology
Journal Reference v143 i5 p1880 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/143/5/1880
Organism rat
Source Curated
CellType osteoblast
MedLine Reference 9155018:1149
Journal EMBO
Journal Reference v16 i8 p1921 (1997)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/16/8/1921
CellLineName HeLa
Source Curated
MedLine Reference 11395922:1192
Journal EBM
Journal Reference v226 i6 p521 (2001)
Journal Link http://www.ebmonline.org/cgi/content/full/226/6/521
Organ pancreas
Source Curated
MedLine Reference 11980669:1051
Journal Cancer Res
Journal Reference v62 i9 p2690 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/9/2690
CellLineName NIH 3T3
Organism mouse
Source Curated
MedLine Reference 11306453:1108
Journal Cancer Res
Journal Reference v61 i7 p2833 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/7/2833
Organism rat
Source Curated
MedLine Reference 10463587:1181
Journal Cancer Res
Journal Reference v59 i16 p3935 (1999)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/59/16/3935
CellLineName HT 29
Source Curated
MedLine Reference 9096336:1159
Journal PNAS
Journal Reference v94 i7 p3004 (1997)
Journal Link http://www.pnas.org/cgi/content/full/94/7/3004
Organism mouse
Source Curated
MedLine Reference 10938135:1225
Journal Mol. Cell. Biol
Journal Reference v20 i17 p6612 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/17/6612
Source Curated
MedLine Reference 10848619:1208
Journal Mol. Cell. Biol
Journal Reference v20 i14 p4979 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/14/4979
CellLineName 293T
Organism yeast
Source Curated
MedLine Reference 9600909:1095
Journal PNAS
Journal Reference v95 i11 p6015 (1998)
Journal Link http://www.pnas.org/cgi/content/full/95/11/6015
Source Curated
MedLine Reference 9520401:1025
Journal PNAS
Journal Reference v95 i7 p3537 (1998)
Journal Link http://www.pnas.org/cgi/content/full/95/7/3537
Organism mouse
Source Curated
MedLine Reference 11971970:1067
Journal Mol. Cell. Biol
Journal Reference v22 i10 p3373 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/10/3373
Source Curated
MedLine Reference 10490604:1294
Journal Mol. Cell. Biol
Journal Reference v19 i10 p6742 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/10/6742
Source Curated
MedLine Reference 12659851:2
Organism mouse
Source Curated
MedLine Reference 9639556:2
Source Curated
MedLine Reference 9331070:5
Tissue testis
Organ breast
Source Curated
MedLine Reference 9177222:4
CellLineName MC/9
Organism mouse
Source Curated
CellType MAST
MedLine Reference 10903735:1022
Journal J. Immunol
Journal Reference v165 i3 p1337 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/165/3/1337
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 8557667:1019
Journal J. Biol. Chem
Journal Reference v271 i2 p639 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/2/639
CellLineName NIH 3T3
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 7797459:1059
Journal J. Biol. Chem
Journal Reference v270 i25 p14843 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/25/14843
Source Curated
MedLine Reference 7759532:1185
Journal J. Biol. Chem
Journal Reference v270 i21 p12781 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/21/12781
CellLineName 3Y1
Organism rat
Source Curated
MedLine Reference 7499206:1117
Journal J. Biol. Chem
Journal Reference v270 i46 p27489 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/46/27489
Source Curated
MedLine Reference 12621033:1197
Journal J. Biol. Chem
Journal Reference v278 i20 p17775 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/20/17775
Source Curated
MedLine Reference 11451947:1155
Journal J. Biol. Chem
Journal Reference v276 i39 p36632 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/39/36632
CellLineName NHK
Source Curated
MedLine Reference 11304531:1293
Journal J. Biol. Chem
Journal Reference v276 i26 p23362 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/26/23362
CellLineName HEK 293
Source Curated
Journal Cell
Journal Reference v88 i2 p213 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/2/213
CellLineName HeLa
Source Curated
Journal Cell
Journal Reference v88 i2 p213 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/2/213
CellLineName HeLa
Source Curated
CellLineName COS I
Source Curated
CellLineName COS I
Source Curated
MedLine Reference 11160861:1227
Journal Mol. Pharm
Journal Reference v59 i2 p254 (2001)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/59/2/254
Source Curated
CellType Embryonic Stem
MedLine Reference 12401521:6
Organism Mus musculus
Source Curated
MedLine Reference 11099494:8
Organism Mus musculus
Source Curated
CellType fibroblast
MedLine Reference 15299005:1015
Journal J. Biol. Chem
Journal Reference v279 i42 p43589 (2004)
Journal Link http://www.jbc.org/cgi/content/full/279/42/43589
CellLineName HEK 293
Organism Mus musculus
Source Curated
MedLine Reference 11278395:1325
Journal J. Biol. Chem
Journal Reference v276 i14 p10801 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/14/10801
Source Curated
MedLine Reference 10490613:1294
Journal Mol. Cell. Biol
Journal Reference v19 i10 p6742 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/10/6742
Source Curated
MedLine Reference 4191218635
Source Curated
CellType neural
MedLine Reference 10523642:10
CellLineName COS-7
Organism mouse
Source Curated
Source Curated
CellType neural
Source Curated
CellType neural
Source Curated
CellType neural
Source Curated
CellType neural
Source Curated
CellType neural
Source Curated
CellType neural
CellLineName COS I
Source Curated
CellLineName COS I
Source Curated
MedLine Reference 9308960:1384
Journal Genes & Dev
Journal Reference v11 i18 p2295 (1997)
Journal Link http://www.genesdev.org/cgi/content/full/11/18/2295
Source Curated
MedLine Reference 15169929:1510
Journal Pharm. Rev
Journal Reference v56 i2 p249 (2004)
Journal Link http://pharmrev.aspetjournals.org/cgi/content/full/56/2/249
Source Curated
CellType macrophage
MedLine Reference 15371522:1060
Journal Cell Sci
Journal Reference v117 i20 p4619 (2004)
Journal Link http://jcs.biologists.org/cgi/content/full/117/20/4619
Source Curated
MedLine Reference 10082520:1123
Journal Mol. Cell. Biol
Journal Reference v19 i4 p2547 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/4/2547
Organism Rattus norvegicus
Source Curated
MedLine Reference 14500727:1
Sentence Once activated, MEKK1 phosphorylates the MAP2K MKK4, which in turn phosphorylates JNK.
Organism Mus musculus
Source Curated
MedLine Reference 10644709:1030
Sentence SEK1, in turn, is activated by MEKK1 ( 30 ).
Journal J. Biol. Chem
Journal Reference v275 i4 p2527 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/4/2527
Source Curated
MedLine Reference 8798679:1059
Sentence MEKK1 phosphorylates and activates SEK1 in vitro and on cotransfection in situ ( 32 ).
Journal J. Biol. Chem
Journal Reference v271 i40 p24313 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/40/24313
Source Curated
MedLine Reference 11402042:1208
Sentence MEKK1 activates the downstream stress-activated protein kinases SEK1 and JNK .
Journal J. Biol. Chem
Journal Reference v276 i33 p30708 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/33/30708
Source Curated
MedLine Reference 11451947:1157
Sentence MEKK1 activates MKK4, which in turn activates JNK and p38 ( 27 , 29 ).
Journal J. Biol. Chem
Journal Reference v276 i39 p36632 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/39/36632
CellLineName NHK
Source Curated
MedLine Reference 10801798:1172
Sentence MEKK1 is a physiological activator of MKK4, which phosphorylates and activates MKK4.
Journal J. Biol. Chem
Journal Reference v275 i27 p20533 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/27/20533
CellLineName HEK 293
Organism Mus musculus
Source Curated