Regulation :

Effect unknown
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:4214:out-urn:agi-go:0003930::unknown
Entities MAP3K1 ---> RAS small monomeric GTPase
References 7
Connectivity 2
MedLine Reference 9685408:10176
Sentence This activation occurs through the activation of Ras, followed by the activation of MEK kinase, MEK, and finally, MAP kinase ( 31 ).
Organism Mus musculus
MedLine Reference 8663585:10125
Sentence Additional Ras-binding proteins have been identified, including phosphatidylinositol-3-OH kinase ( 2 ), AF6 ( 25 ), Rin-1 ( 26 ), NF1 ( 27 ), etaPKC ( 28 ), and MEK kinase 1 ( 29 ), some or all of which may have roles in mediating Ras activity, including induction of cellular transformation.
Journal J. Biol. Chem
Journal Reference v271 i28 p16439
Journal Link http://www.jbc.org/cgi/content/full/271/28/16439
Organism Mus musculus
MedLine Reference 9530111:10214
Sentence In the case of c-Raf-1-independent activation of p42mapk, genistein may inhibit an unidentified PTK upstream of MEKK1, and because MEKK1 has also been shown to bind to Ras-GTP ( 49 ), a genistein-sensitive PTK regulating Ras activation may be involved in cytokine-induced activation of p42mapk.
Journal Cell Phys
Journal Reference v274 i3 pC789
Journal Link http://ajpcell.physiology.org/cgi/content/full/274/3/C789
MedLine Reference 9685408:1178
Sentence This activation occurs through the activation of Ras, followed by the activation of MEK kinase, MEK, and finally, MAP kinase ( 31 ).
Journal J. Biol. Chem
Journal Reference v273 i32 p20517 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/32/20517
Organism mouse
Source Curated
MedLine Reference 8537333:1080
Sentence In contrast to the inhibition of GH-stimulated ERK2/MAPK activity by dominant negative Ras, activation by Delta MEKK appeared to be enhanced in cells expressing dominant negative Ras by a presently unknown mechanism.
Journal J. Biol. Chem
Journal Reference v270 i52 p30837 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/52/30837
Source Curated
CellLineName 293
MedLine Reference 8663585:1125
Sentence Additional Ras-binding proteins have been identified, including phosphatidylinositol-3-OH kinase ( 2 ), AF6 ( 25 ), Rin-1 ( 26 ), NF1 ( 27 ), etaPKC ( 28 ), and MEK kinase 1 ( 29 ), some or all of which may have roles in mediating Ras activity, including induction of cellular transformation.
Journal J. Biol. Chem
Journal Reference v271 i28 p16439 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/28/16439
Organism mouse
Source Curated
MedLine Reference 9530111:1215
Sentence In the case of c-Raf-1-independent activation of p42mapk, genistein may inhibit an unidentified PTK upstream of MEKK1, and because MEKK1 has also been shown to bind to Ras-GTP ( 49 ), a genistein-sensitive PTK regulating Ras activation may be involved in cytokine-induced activation of p42mapk.
Tissue endothelial
Journal Cell Phys
Journal Reference v274 i3 pC789 (1998)
Journal Link http://ajpcell.physiology.org/cgi/content/full/274/3/C789
Source Curated