Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:4214:inout-urn:agi-go:0003930:
Entities MAP3K1 ---- RAS small monomeric GTPase
References 25
MedLine Reference 7744823:6
Sentence These findings indicate that MEKK1 directly binds Ras.GTP.
MedLine Reference 11082445:10178
Sentence Direct interaction between Ras and MEKK1 may result in the latter being stimulated (Russell et al., 1995 ).
Journal JPET
Journal Reference v295 i3 p1094
Journal Link http://jpet.aspetjournals.org/cgi/content/full/295/3/1094
MedLine Reference 10866655:10320
Sentence Previous studies have demonstrated that the kinase domain of MEKK-1 interacts directly with Ras in a GTP-dependent manner ( 55 ).
Journal Mol. Cell. Biol
Journal Reference v20 i14 p4979
Journal Link http://mcb.asm.org/cgi/content/full/20/14/4979
Organism Mus musculus
MedLine Reference 101000522:11209
Journal Cell
Journal Reference v88 i2 p213
Journal Link http://www.cell.com/cgi/content/full/88/2/213
MedLine Reference 9686756:10174
Journal Circulation Res
Journal Reference v83 i2 p167
Journal Link http://circres.ahajournals.org/cgi/content/full/83/2/167
Organism Mus musculus
MedLine Reference 9530111:10214
Journal Cell Phys
Journal Reference v274 i3 pC789
Journal Link http://ajpcell.physiology.org/cgi/content/full/274/3/C789
MedLine Reference 12600818:10244
Journal AJRCMB
Journal Reference v28 i6 p762
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/28/6/762
MedLine Reference 11782455:10283
Journal J. Biol. Chem
Journal Reference v277 i12 p10283
Journal Link http://www.jbc.org/cgi/content/full/277/12/10283
Organism Mus musculus
MedLine Reference 10082535:10276
Journal Mol. Cell. Biol
Journal Reference v19 i4 p2690
Journal Link http://mcb.asm.org/cgi/content/full/19/4/2690
Organism Mus musculus
MedLine Reference 8621725:10283
Journal J. Biol. Chem
Journal Reference v271 i6 p3229
Journal Link http://www.jbc.org/cgi/content/full/271/6/3229
Organism Mus musculus
MedLine Reference 9305638:10167
Journal EMBO
Journal Reference v16 i16 p4961
Journal Link http://emboj.oupjournals.org/cgi/content/full/16/16/4961
MedLine Reference 11784851:10375
Journal Mol. Cell. Biol
Journal Reference v22 i3 p737
Journal Link http://mcb.asm.org/cgi/content/full/22/3/737
Organism Rattus norvegicus
MedLine Reference 12600818:1241
Sentence While as noted above MEKK1 may interact with Ras and function as a downstream effector ( 26 ?????? 28 ), it has been shown in HEK293 cells that TNF treatment enhances the binding of native TRAF2 to MEKK1, stimulating MEKK1 kinase activity in a Ras-independent manner ( 61 ).
Journal AJRCMB
Journal Reference v28 i6 p762 (2003)
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/28/6/762
Source Curated
CellLineName HEK 293
MedLine Reference 9530111:1215
Sentence In the case of c-Raf-1-independent activation of p42mapk, genistein may inhibit an unidentified PTK upstream of MEKK1, and because MEKK1 has also been shown to bind to Ras-GTP ( 49 ), a genistein-sensitive PTK regulating Ras activation may be involved in cytokine-induced activation of p42mapk.
Tissue endothelial
Journal Cell Phys
Journal Reference v274 i3 pC789 (1998)
Journal Link http://ajpcell.physiology.org/cgi/content/full/274/3/C789
Source Curated
MedLine Reference 9686756:1174
Sentence The dominant-interfering MEKK1 can also bind to Ras and thereby also inhibit activation of ERK. 35 In order to establish that inhibition of ERK activation by dominant-interfering MEKK1 is not responsible for the inhibitory effect on genetic markers of hypertrophic growth, we performed parallel experiments using dominant-interfering Raf-1, which binds Ras and inhibits the MEK/ERK pathway.
CellType myocyte
Journal Circulation Res
Journal Reference v83 i2 p167 (1998)
Journal Link http://circres.ahajournals.org/cgi/content/full/83/2/167
Organism rat
Source Curated
MedLine Reference 10938285:1267
CellType neural
Journal J. Biol. Chem
Journal Reference v275 i43 p33487 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/43/33487
Source Curated
CellLineName PC 12
MedLine Reference 11784851:1375
Journal Mol. Cell. Biol
Journal Reference v22 i3 p737 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/3/737
Organism rat
Source Curated
MedLine Reference 10848619:1321
Journal Mol. Cell. Biol
Journal Reference v20 i14 p4979 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/14/4979
Organism yeast
Source Curated
MedLine Reference 10082534:1276
Journal Mol. Cell. Biol
Journal Reference v19 i4 p2690 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/4/2690
Organism mouse
Source Curated
MedLine Reference 11082445:1178
Journal JPET
Journal Reference v295 i3 p1094 (2000)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/295/3/1094
Source Curated
MedLine Reference 8621725:1283
CellType t cell
Journal J. Biol. Chem
Journal Reference v271 i6 p3229 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/6/3229
Organism mouse
Source Curated
CellLineName JURKAT
MedLine Reference 7744823:1011
Journal J. Biol. Chem
Journal Reference v270 i20 p11757 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/20/11757
Source Curated
MedLine Reference 11782455:1281
Journal J. Biol. Chem
Journal Reference v277 i12 p10283 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/12/10283
Organism mouse
Source Curated
MedLine Reference 9305638:1095
Journal EMBO
Journal Reference v16 i16 p4961 (1997)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/16/16/4961
Source Curated
CellLineName COS
MedLine Reference 2512981180
Sentence For example, MEKK1 has been shown to bind Ras in a GTP-dependent manner and thus its activity may be regulated in a similar fashion ( Russell et al., 1995 ).
Journal Cell
Journal Reference v88 i2 p213 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/2/213
Source Curated