Protein : SMAC


Owner	Public
URN	urn:agi-llid:56616
Hugo ID	21528
Connectivity	318
Name	SMAC
Description	diablo homolog (Drosophila)
Notes	This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively.


RGD ID	1310885


MGI ID	1913843


Cell Localization	Mitochondria


Pathway	Mitochondrial control of Apoptosis
	Death receptor signaling
	Inhibition of Apoptosis
	Apoptosis
	Copy of 'Apoptosis'
	Apoptosis2


Group	apoptosis
	caspase activation
	caspase activation via cytochrome c
	positive regulation of apoptosis
	induction of apoptosis
	induction of apoptosis via death domain receptors
	induction of apoptosis by oxidative stress
	cytoplasm
	mitochondrion
	protein binding


GenBank ID	NC_000012
	NM_138929
	NP_620307
	NM_019887
	NP_063940
	NM_138930
	NP_620308
	NT_009755
	NW_925395
	AC_000055
	AC048338
	AF262240
	AAF87716
	AF298770
	AAG22077
	AK001399
	AK024768
	BAB14994
	AK057778
	BAB71568
	AK222664
	BAD96384
	AY313210
	AAQ86939
	BC004417
	AAH04417
	BC011909
	AAH11909
	BC046209
	BC095468
	AAH95468
	CD742753
	CF128595
	CR596276
	CR598154
	CR598498
	CR612340
	CR621745
	N66735
	Q502X2
	Q53HB7
	Q6W3F3
	Q9NR28
	NC_000071
	NM_023232
	NP_075721
	NT_078458
	NW_000236
	NW_001030796
	AC_000027
	AC157931
	AF203914
	AAF82190
	AK002887
	AK012760
	BAB28450
	AK077198
	BAC36676
	AK082903
	AK133194
	BAE21552
	AK135627
	AK169573
	BAE41235
	AU040403
	BC024780
	AAH24780
	BC054109
	AAH54109
	BC094617
	BG064850
	BG078180
	BY080746
	Q542V8
	Q9JIQ3
	NC_005111
	NM_001008292
	NP_001008293
	NW_001084677
	NW_047375
	AC_000080
	BC086366
	AAH86366
	Q5RK17


Source	Curated


LocusLink ID	56616
	66593
	288753


Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus


OMIM ID	605219


Alias	SMAC
	SMAC3
	DIABLO-S
	FLJ10537
	FLJ25049
	diablo
	0610041G12Rik
	mitochondrial Smac protein
	direct IAP-binding protein with low pI
	second mitochondria-derived activator of caspase
	AU040403
	direct IAP binding protein with low PI
	MGC105680


GO ID	0005515
	0006915
	0008635
	0006917
	0008625
	0005739
	0006919
	0008631
	0043065
	0005737


Swiss-Prot Accession	Q502X2
	Q53HB7
	Q6W3F3
	Q9NR28
	Q542V8
	Q9JIQ3
	Q5RK17


Unigene ID	Hs.169611
	Mm.46716
	Rn.9090