Protein : MAP3K5


Owner	Public
URN	urn:agi-llid:4217
Hugo ID	6857
Connectivity	434
Name	MAP3K5
Description	mitogen activated protein kinase kinase kinase 5
Notes	Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.


MGI ID	1346876


Pathway	Jnk-mapk
	p38 MAPK
	Death receptor signaling
	p38 Signaling
	SAPK-JNK Signaling
	Apoptosis
	MAPK signaling
	TNFRSF6 -> DDIT3 signaling pathway
	TNFRSF6 -> HSF1 signaling pathway
	TNFRSF6 -> RB1-E2F1 signaling pathway
	IL1R -> NF-kB signaling pathway
	TGFBR -> AP-1 signaling pathway
	TGFBR -> ATF2 signaling pathway
	TGFBR -> CREB1 signaling pathway
	TGFBR -> ELK1-SRF signaling pathway
	TGFBR -> ELK4-SRF signaling pathway
	TGFBR -> GADD153 signaling pathway
	TGFBR -> MAX signaling pathway
	TGFBR -> MEF2A signaling pathway
	TGFBR -> MEF2C signaling pathway
	TGFBR -> TP53 signaling pathway
	TNFRs -> AP-1 signaling pathway
	TNFRs -> ATF2 signaling pathway
	TNFRs -> CREB1 signaling pathway
	TNFRs -> ELK1-SRF signaling pathway
	TNFRs -> ELK4-SRF signaling pathway
	TNFRs -> NF-kB signaling pathway
	NGFR -> AP-1 signaling pathway
	TNFRs -> TP53 signaling pathway
	TNFRSF1A -> AP-1 signaling pathway
	TNFRSF1A -> ATF2 signaling pathway
	TNFRSF1A -> CREB1 signaling pathway
	NGFR -> CEBPB signaling pathway
	TNFRSF1A -> ELK1-SRF signaling pathway
	NGFR -> CREB1 signaling pathway
	NGFR -> ELK1-SRF signaling pathway
	TNFRSF1A -> ELK4-SRF signaling pathway
	NGFR -> ELK4-SRF signaling pathway
	NGFR -> NF-kB signaling pathway
	NGFR -> TP53 signaling pathway
	TNFRSF1A -> TP53 signaling pathway
	TNFRSF5 -> RB1-E2F1 signaling pathway
	EDARs -> AP-1 signaling pathway
	EDARs -> NF-kB signaling pathway
	Copy of 'Apoptosis'
	Apoptosis2
	p38 Signaling2


Group	Kinases
	MAPKKK cascade
	activation of MAPK activity
	activation of JNK activity
	apoptosis
	induction of apoptosis by extracellular signals
	protein amino acid phosphorylation
	response to stress
	nucleotide binding
	protein binding
	metal ion binding
	magnesium ion binding
	ATP binding
	identical protein binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase kinase activity
	caspase activator activity


Source	Curated


LocusLink ID	4217
	26408


Organism	Homo sapiens
	Mus musculus


OMIM ID	602448


Alias	ASK1
	MEKK5
	MAPKKK5
	RP3-325F22.4
	mitogen-activated protein kinase kinase kinase 5
	MAP/ERK kinase kinase 5
	MAPK/ERK kinase kinase 5
	apoptosis signal regulating kinase
	ASK
	MGC141518
	MGC141519
	7420452D20Rik
	mitogen activated protein kinase kinase kinase 5
	MEK kinase 5


Unigene ID	Hs.186486
	Mm.6595