Protein : MAPK8
Owner Public
URN urn:agi-llid:5599
Hugo ID 6881
Connectivity 3359
Name MAPK8
Description mitogen-activated protein kinase 8
Notes a stress-activated protein kinase [RGD]
RGD ID 621506
MGI ID 1346861
Cell Localization Nucleus
Pathway Jnk-mapk
Wnt signaling
FAS signaling
Jak-Stat Pathway from IL6 Receptor
Insulin pathway
EGF signaling
Death receptor signaling
PDGF signaling
TNFR1 signaling
Erythropoietin signaling
SAPK-JNK Signaling
ATM signaling
Toll-Like Receptor pathway
IL-2 signaling
NGF signaling
Apoptosis
Integrin Signaling
TNFRSF6 -> DDIT3 signaling pathway
EDG3/5 -> AP-1 signaling pathway
TNFRSF6 -> HSF1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
NTRK1 -> SMAD3 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
EGFR -> ATF2 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> TP53 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
F2R -> AP-1 signaling pathway
ENDRA -> AP-1 signaling pathway
RET -> HSF1 signaling pathway
ENDRB -> AP-1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
PTAFR -> AP-1 signaling pathway
PTAFR -> ATF1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
ERBB2 -> ETS2 signaling pathway
TGFBR -> AP-1 signaling pathway
Frizzled -> JUN signaling pathway
Frizzled -> PAX2 signaling pathway
ITGB1 -> AP-1 signaling pathway
TLR2/4/5/7/9 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> ELK1-SRF signaling pathway
GFRs -> ELK4-SRF signaling pathway
TLR2/6 -> AP-1 signaling pathway
GFRs -> MYC signaling pathway
TNFRs -> AP-1 signaling pathway
GNRHR -> ELK1-SRF signaling pathway
GNRHR -> ELK4-SRF signaling pathway
MPL -> SPI1 signaling pathway
TNFRs -> ATF2 signaling pathway
TNFRs -> ELK1-SRF signaling pathway
TNFRs -> ELK4-SRF signaling pathway
NGFR -> AP-1 signaling pathway
TNFRs -> TP53 signaling pathway
TNFRSF1A -> AP-1 signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
NGFR -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
NGFR -> ELK4-SRF signaling pathway
NGFR -> TP53 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDARs -> AP-1 signaling pathway
Copy of 'Apoptosis'
Apoptosis2
Group Kinases
signal transduction
JNK cascade
cell motility
ATP synthesis coupled proton transport
protein amino acid phosphorylation
regulation of transcription, DNA-dependent
ossification
response to stress
proton-transporting two-sector ATPase complex
nucleotide binding
protein binding
ATP binding
transferase activity
hydrogen-transporting ATPase activity, rotational mechanism
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein-tyrosine kinase activity
MAP kinase activity
JUN kinase activity
hydrogen-transporting ATP synthase activity, rotational mechanism
GenBank ID NC_000010
NM_002750
NP_002741
NM_139049
NP_620637
NM_139046
NP_620634
NM_139047
NP_620635
NT_017696
NW_924685
AC_000053
AC016397
AL137667
CR614448
DQ234352
ABB29981
L26318
AAA36131
U34822
AAC50607
U35004
AAC50610
U35005
AAC50611
P45983
NC_000080
NM_016700
NP_057909
NT_039606
NW_000091
NW_001030543
AC_000036
AC154649
AB005663
BAA85875
AK030767
AK032486
AK039129
AK039254
AK043102
BAC31460
AK044768
AK047936
AK053062
AK085745
AK139498
AK162915
AW909414
BB184171
BC053027
AAH53027
BG068565
BG069159
BG081594
BG082181
BM940281
Q544A0
Q7TSJ7
Q91Y86
NC_005115
XM_341399
XP_341400
NW_001084711
XM_001056513
XP_001056513
NW_047469
AC_000084
L27129
AAA42111
P49185
Source Curated
LocusLink ID 5599
26419
116554
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 601158
Alias JNK
JNK1
PRKM8
SAPK1
JNK1A2
JNK21B1/2
mitogen-activated protein kinase 8
protein kinase JNK1
JNK1 beta protein kinase
JNK1 alpha protein kinase
c-Jun N-terminal kinase 1
stress-activated protein kinase JNK1
mitogen-activated protein kinase 8 transcript variant 2
AI849689
mitogen activated protein kinase 8
c-Jun N-terminal kinase
protein kinase mitogen-activated 8
c-jun NH2-terminal kinase
GO ID 0005524
0004705
0004707
0000166
0005515
0004674
0016740
0007254
0006928
0006468
0006950
0007165
0046933
0046961
0016301
0004672
0004713
0015986
0001503
0016469
0006355
Swiss-Prot Accession P45983
Q544A0
Q7TSJ7
Q91Y86
P49185
Unigene ID Hs.138211
Mm.21495
Rn.4090