Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:841:out-urn:agi-llid:637::positive
Entities CASP8 --+> BID
References 195
Connectivity 2
MedLine Reference 16740251:3
Sentence Inhibition of caspase 8 blocked Bid cleavage and Bax conformational change.
MedLine Reference 15240700:4
Sentence It also promotes the transcription of caspase-8, the enzyme that cleaves and activates Bid.
Organism Mus musculus
MedLine Reference 12154014:1
Sentence Apo2L/TRAIL-induced apoptosis involves caspase-8-mediated cleavage of BID.
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Organism Rattus norvegicus
CellType hepatocyte
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Organ gastric
CellLineName SNU-620
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Organism Mus musculus
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Tissue endothelial
Organism Rattus norvegicus
CellType myocyte
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Organism Mus musculus
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Organism Mus musculus
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Organism Rattus norvegicus
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Journal Cancer Res
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Source Curated
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Journal Cancer Res
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Source Curated
CellLineName lncap
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Sentence Interestingly, death receptors can also activate the intrinsic pathway through caspase-8-mediated activation of Bid.
Journal Cancer Res
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Source Curated
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Journal Cancer Res
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Source Curated
CellLineName MCF7
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Sentence Inhibition of PKC Suppresses the Cleavage of Caspase-9 In models of apoptosis, active caspase-8 either directly induces procaspase-3 cleavage or induces cleavage indirectly by a mitochondrial amplification loop requiring BID cleavage, cytochrome C release, and activation of procaspase-9.
Journal AJRCMB
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Organism mouse
Source Curated
CellType b cell
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Source Curated
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Source Curated
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Journal Link http://www.jbc.org/cgi/content/full/278/31/29184
Organism mouse
Source Curated
CellLineName A 549
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Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/278/21/19426
Organism rat
Source Curated
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Journal Heart Circul
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Organism dog
Source Curated
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Organism mouse
Source Curated
CellLineName li
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Journal Circulation Res
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Journal Link http://circres.ahajournals.org/cgi/content/full/91/3/183
Organism rat
Source Curated
CellType cardiomyocyte
Journal Cell
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Source Curated
Journal Cell
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Source Curated
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Source Curated
CellLineName HL 60
MedLine Reference 11895859:1228
Journal Carcinogenesis
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Source Curated
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Organism mouse
Source Curated
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Journal Link http://www.jimmunol.org/cgi/content/full/169/6/2851
Source Curated
CellType t cell
CellLineName JURKAT
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Source Curated
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Source Curated
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Source Curated
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Journal Link http://www.jbc.org/cgi/content/full/277/37/34217
Organism mouse
Source Curated
CellType neural
MedLine Reference 11980894:1309
Journal J. Biol. Chem
Journal Reference v277 i28 p25568 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/28/25568
Source Curated
CellLineName HeLa
MedLine Reference 11801595:1037
Journal J. Biol. Chem
Journal Reference v277 i13 p11345 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/13/11345
Source Curated
MedLine Reference 11733517:1029
Journal J. Biol. Chem
Journal Reference v277 i6 p4351 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/6/4351
Source Curated
MedLine Reference 11369777:1142
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/276/29/27432
Organ liver
Organism mouse
Source Curated
MedLine Reference 11346652:1154
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/276/28/26398
Source Curated
CellLineName HT 1080
MedLine Reference