Protein : MAPK1
Owner Public
URN urn:agi-llid:5594
Hugo ID 6871
Connectivity 5802
Name MAPK1
Description mitogen activated protein kinase 1
Notes kinase involved in intracellular signaling; component of Mapk signaling pathway [RGD]
RGD ID 70500
MGI ID 1346858
Cell Localization Nucleus
Pathway LT-alpha
p40 MAPK
Insulin Receptor Signaling
Antiapoptotic Pathways From IGF-1R
Jak-Stat Pathway from IL6 Receptor
Mitochondrial control of Apoptosis
Insulin pathway
EGF signaling
PDGF signaling
TNF-alpha
MAPK-ERK in Growth and Differentiation
Inhibition of Apoptosis
IL-6 signaling
G-protein Coupled Receptor signaling
IL-3 signaling
Toll-Like Receptor pathway
CREB signaling
IL-2 signaling
NGF signaling
Erk-PI3K in Collagen Binding
Apoptosis
Integrin Signaling
MAPK signaling
AGTR1 -> ELK1-SRF signaling pathway
Notch -> CREB1 signaling pathway
PTPRC -> BCL6 signaling pathway
Notch -> ELK1-SRF signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
Notch -> TCF3 signaling pathway
EDG2 -> ELK4-SRF signaling pathway
EDG3/5 -> AP-1 signaling pathway
AGTR1 -> TP53 signaling pathway
TNFRSF6 -> HSF1 signaling pathway
AGTR2 -> CREB1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
VIPR1 -> CEBPB signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
VIPR1 -> CEBPD signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
AGTR2 -> TP53 signaling pathway
ERBB2 -> ETV4 signaling pathway
EGFR -> ATF2 signaling pathway
EGFR -> SMAD1 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
VIPR1 -> CREB1 signaling pathway
NTRKs -> TP53 signaling pathway
OPRs -> CREB1 signaling pathway
IGF1R -> ELK1-SRF signaling pathway
B-cell receptor -> AP-1 signaling pathway
EGFR/ERBB2 -> HIF1A signaling pathway
ERBB2/3 -> SP1 signaling pathway
IGF1R -> ELK4-SRF signaling pathway
OPRs -> ELK1-SRF signaling pathway
IGF1R -> HIF1A signaling pathway
OPRs -> ELK4-SRF signaling pathway
IGF1R -> MYC signaling pathway
OPRs -> STAT3 signaling pathway
IGF1R -> SREBF1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
F2R -> AP-1 signaling pathway
PECAM1 -> SP1 signaling pathway
ENDRA -> AP-1 signaling pathway
PLAUR -> ELK1-SRF signaling pathway
RET -> HSF1 signaling pathway
PLAUR -> ELK4-SRF signaling pathway
ENDRA -> CREB1 signaling pathway
ENDRB -> AP-1 signaling pathway
F2R -> CREB1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
PTAFR -> AP-1 signaling pathway
F2R -> SP1 signaling pathway
PTAFR -> ATF1 signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
EPOR -> ELK1-SRF signaling pathway
PTGFR -> CREB1 signaling pathway
EPOR -> ELK4-SRF signaling pathway
SELE -> ELK1-SRF signaling pathway
IL1R -> NF-kB signaling pathway
EPOR -> FOS signaling pathway
PTGFR -> ELK1-SRF signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
PTGFR -> MYC signaling pathway
CCKAR -> ELK1-SRF signaling pathway
PTGFR -> TCF3 signaling pathway
SELE -> ELK4-SRF signaling pathway
CCKAR -> ELK4-SRF signaling pathway
PTGIR -> ATF1 signaling pathway
CCKBR -> ELK1-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
CCKBR -> ELK4-SRF signaling pathway
ERBB2 -> ETS1 signaling pathway
PTGIR -> CREB1 signaling pathway
PTGIR -> ELK1-SRF signaling pathway
ERBB2 -> ETS2 signaling pathway
PTGIR -> MYC signaling pathway
ERBB2 -> ETV1 signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL2R -> MYC signaling pathway
T-cell receptor -> AP-1 signaling pathway
IL4R -> ELK1-SRF signaling pathway
CD19 -> AP-1 signaling pathway
IL4R -> ELK4-SRF signaling pathway
IL4R -> HMGY signaling pathway
CD19 -> ELK1-SRF signaling pathway
CD19 -> ELK4-SRF signaling pathway
TACR1 -> ELK1-SRF signaling pathway
IL6R -> CEBPB signaling pathway
FGFRs -> RUNX2 signaling pathway
IL6R -> ELK1-SRF signaling pathway
IL6R -> ELK4-SRF signaling pathway
CD22/72 -> AP-1 signaling pathway
TACR1 -> ELK4-SRF signaling pathway
TBXA2R -> CREB1 signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
ADORA1 -> AP-1 signaling pathway
INSR -> SREBF1 signaling pathway
INSR -> SREBF2 signaling pathway
FSHR -> CREB1 signaling pathway
FSHR -> ELK1-SRF signaling pathway
FSHR -> ELK4-SRF signaling pathway
ITGB1 -> AP-1 signaling pathway
FSHR -> GATA4 signaling pathway
CD38 -> AP-1 signaling pathway
GCGR -> CREB1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
CD38 -> CEBPA signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
CD38 -> CREB1 signaling pathway
CD38 -> ELK1-SRF signaling pathway
CD38 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
GCGR -> ELK1-SRF signaling pathway
CD38 -> MYC signaling pathway
GCGR -> ELK4-SRF signaling pathway
ITGB1 -> SREBF2 signaling pathway
GCGR -> SP1 signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
CD38 -> TCF3 signaling pathway
GFRs -> ELK1-SRF signaling pathway
ADRA1B -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KIT -> MITF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CHRNA7 -> CREB1 signaling pathway
GHR -> ELK4-SRF signaling pathway
GHR -> MYC signaling pathway
LEPR -> ELK1-SRF signaling pathway
ADRA1B -> STAT3 signaling pathway
CNRs -> CREB1 signaling pathway
TNFRs -> AP-1 signaling pathway
LEPR -> ELK4-SRF signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
GNRHR -> ELK1-SRF signaling pathway
GNRHR -> ELK4-SRF signaling pathway
GRIN1 -> CREB1 signaling pathway
ADRB2 -> CREB1 signaling pathway
GRM1/5 -> CREB1 signaling pathway
MPL -> CREB1 signaling pathway
MPL -> SP1 signaling pathway
TNFRs -> ATF2 signaling pathway
HTR2A -> ELK1-SRF signaling pathway
TNFRs -> CREB1 signaling pathway
TNFRs -> ELK1-SRF signaling pathway
TNFRs -> ELK4-SRF signaling pathway
HTR2A -> ELK4-SRF signaling pathway
AGER -> CREB1 signaling pathway
NCAM1 -> CREB1 signaling pathway
NCAM1 -> ELK1-SRF signaling pathway
DRD1 -> CREB1 signaling pathway
HTR2A -> GATA4 signaling pathway
NCAM1 -> MYC signaling pathway
NGFR -> AP-1 signaling pathway
TNFRs -> TP53 signaling pathway
TNFRSF1A -> AP-1 signaling pathway
ICAM1 -> CREB1 signaling pathway
DRD1 -> ELK1-SRF signaling pathway
DRD1 -> ELK4-SRF signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> CREB1 signaling pathway
ICAM1 -> ELK1-SRF signaling pathway
NGFR -> CEBPB signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
NGFR -> CREB1 signaling pathway
ICAM1 -> ELK4-SRF signaling pathway
NGFR -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
NGFR -> ELK4-SRF signaling pathway
ICAM1 -> MYC signaling pathway
DRD2 -> CREB1 signaling pathway
NGFR -> TP53 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGER -> SP1 signaling pathway
AGTR1 -> CREB1 signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDARs -> AP-1 signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Aquaporin
Copy of 'Apoptosis'
Apoptosis2
Apoptosis2
Group Kinases
signal transduction
synaptic transmission
intracellular signaling cascade
protein kinase cascade
MAPKKK cascade
nuclear translocation of MAPK
cell cycle
induction of apoptosis
cytosine metabolism
protein amino acid phosphorylation
peptidyl-serine phosphorylation
positive regulation of transcription
phosphorylation
organ morphogenesis
response to stress
chemotaxis
response to DNA damage stimulus
insoluble fraction
cytoplasm
cytosol
nucleus
nucleotide binding
protein binding
ATP binding
phosphotyrosine binding
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein-tyrosine kinase activity
MAP kinase activity
GenBank ID NC_000022
NM_002745
NP_002736
NM_138957
NP_620407
NT_011520
NW_927628
AC_000065
AP000553
AP000554
AP000555
DQ508104
ABF47102
AI004470
AK090869
BC017832
AAH17832
BC099905
AAH99905
CR621660
Z11694
CAA77752
Z11695
CAA77753
P28482
NC_000082
NM_011949
NP_036079
NM_001038663
NP_001033752
NT_039624
NW_000107
NW_001030584
AC_000038
AC166346
AC166832
D87271
BAA22620
AI450767
AK013699
AK018549
AK035386
BAC29053
AK043621
AK048127
BAC33251
AK048159
AK087925
BAC40044
AK132241
BAE21053
AK148853
BAE28679
AK163692
AK193161
AK193200
AK205643
AK209313
AK210736
AK211534
AK216848
AK218813
BB648734
BC006708
AAH06708
BC058258
AAH58258
BG064270
BM209765
D10939
BAA01733
X58712
CAA41548
O35558
P63085
NC_005110
NM_053842
NP_446294
NW_001084663
NW_047358
AC_000079
M64300
AAA41124
P63086
Source Curated
LocusLink ID 5594
26413
116590
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 176948
Alias ERK
p38
p40
p41
ERK2
ERT1
MAPK2
PRKM1
PRKM2
P42MAPK
p41mapk
mitogen-activated protein kinase 1
protein tyrosine kinase ERK2
mitogen-activated protein kinase 2
extracellular signal-regulated kinase 2
C78273
AA407128
AU018647
9030612K14Rik
mitogen activated protein kinase 1
extracellular-signal-regulated kinase 1
GO ID 0005524
0004707
0000166
0004674
0016740
0007049
0006935
0006917
0006468
0006950
0007165
0007268
0016301
0001784
0005515
0004672
0004713
0000165
0019858
0009887
0018105
0016310
0006974
0005737
0005634
0007242
0000189
0045941
0007243
0005829
0005626
Swiss-Prot Accession P28482
O35558
P63085
P63086
MedScan ID 5594
Unigene ID Hs.431850
Mm.196581
Rn.34914
LocatorString pmquery:aquaporin