Protein : Rac1
Owner Public
URN urn:agi-llid:5879
Hugo ID 9801
Connectivity 1461
Name Rac1
Description ras-related C3 botulinum toxin substrate 1
Notes The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
RGD ID 619755
MGI ID 97845
Cell Localization Plasma membrane
Pathway p38 Signaling
EPHA3
CREB signaling
EPHA2
EDG2 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
NTRK1 -> SMAD3 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
EGFR -> ATF2 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> TP53 signaling pathway
ERBB2/3 -> SP1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
EGFR/ERBB3 -> MEF2A signaling pathway
F2R -> AP-1 signaling pathway
EGFR/ERBB3 -> MEF2C signaling pathway
RET -> HSF1 signaling pathway
ENDRB -> AP-1 signaling pathway
F2R -> CREB1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
F2R -> SP1 signaling pathway
IL1R -> NF-kB signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
IL1R -> STAT3 signaling pathway
ERBB2 -> ETS2 signaling pathway
ERBB2 -> ETV1 signaling pathway
CD28 -> ATF1 signaling pathway
CD28 -> ATF2 signaling pathway
CD28 -> CREB1 signaling pathway
Frizzled -> JUN signaling pathway
CD28 -> NF-kB signaling pathway
Frizzled -> PAX2 signaling pathway
TLR1/2 -> NF-kB signaling pathway
ITGB1 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> NF-kB signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
GFRs -> ELK1-SRF signaling pathway
GFRs -> ELK4-SRF signaling pathway
GFRs -> MYC signaling pathway
TLR2/6 -> NF-kB signaling pathway
GFRs -> NCOR2 signaling pathway
KIT -> MITF signaling pathway
AGER -> CREB1 signaling pathway
DRD2 -> AP-1 signaling pathway
DRD2 -> CREB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGER -> SP1 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Group Gtp binding proteins
cell adhesion
small GTPase mediated signal transduction
Rac protein signal transduction
positive regulation of Rho protein signal transduction
dendrite development
cell motility
cell proliferation
cell migration
ruffle organization and biogenesis
lamellipodium biogenesis
cytoskeleton organization and biogenesis
actin filament polymerization
positive regulation of actin filament polymerization
negative regulation of receptor mediated endocytosis
protein transport
endocytosis
positive regulation of phosphoinositide 3-kinase activity
chemotaxis
hyperosmotic response
cell projection
intracellular
membrane
membrane fraction
lamellipodium
cytoplasm
cytoplasmic membrane-bound vesicle
extrinsic to plasma membrane
nucleotide binding
protein binding
GTP binding
GTPase activity
GenBank ID NC_000007
NM_198829
NP_942126
NM_018890
NP_061485
NM_006908
NP_008839
NT_007819
NT_079592
NW_923217
AC_000050
AC_000068
AC009412
AAS07511
AAS07512
AJ132695
CAA10733
CAB53579
AL833528
CH236963
EAL23718
EAL23719
EAL23720
CS026591
CAI61762
CS026817
CAI61874
DQ165078
AAZ80485
U80083
AAC50998
AF136373
AAD30547
AF498964
AAM21111
AJ132694
CAA10732
AK054993
AK122742
AY279384
AAQ16632
BC004247
AAH04247
BC050687
AAH50687
BC107748
AAI07749
BG437715
BQ689587
BT007121
AAP35785
CR591797
CR612844
CR621312
CR624866
D25274
M29870
AAA36537
M31467
AAA36544
U77544
AAB36753
U85236
AAB58438
U91215
AAC51432
Y12699
CAA73231
AAB22206
P63000
Q5JAA8
NC_000071
NM_009007
NP_033033
NT_081055
NW_000241
NW_001030796
AC_000027
AC163995
AK008435
BAB25667
AK009017
BAB26027
AK011072
BAB69451
AK034601
BAC28767
AK047969
BAC33203
AK076023
BAC36128
AK081613
BAC38272
AK088825
BAC40596
AK166383
BAE38744
AK184868
AK186906
AK190884
AK193118
AK195884
AK199407
AK216533
AL023026
BC003828
AAH03828
BC051053
AAH51053
BG064327
BG076502
BG088950
U25107
AAB42023
X57277
CAA40545
P63001
Q8BPG5
Q8C4N8
Q9D859
NC_005111
NM_134366
NP_599193
NW_001084671
NW_047368
AC_000080
AF385833
AAK66567
AY491395
AAR84574
Q6RUV5
Source Curated
LocusLink ID 5879
19353
363875
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 602048
Alias MIG5
TC-25
p21-Rac1
MGC111543
ras-related C3 botulinum toxin substrate 1
migration-inducing gene 5
migration-inducing protein 5
rho family, small GTP binding protein Rac1
AL023026
D5Ertd559e
RAS-related C3 botulinum substrate 1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
GO ID 0005525
0003924
0000166
0005515
0030041
0030032
0048261
0035025
0031529
0007264
0005622
0007155
0016477
0007010
0016358
0006897
0006972
0030838
0043552
0015031
0042995
0005737
0016023
0019897
0030027
0016020
0005624
0016601
0006928
0008283
0006935
Swiss-Prot Accession AAB22206
P63000
Q5JAA8
P63001
Q8BPG5
Q8C4N8
Q9D859
Q6RUV5
Unigene ID Hs.413812
Hs.551925
Hs.632900
Hs.633454
Mm.292510
Mm.342177
Rn.29157