Protein : MAPK14
Owner Public
URN urn:agi-llid:1432
Hugo ID 6876
Connectivity 2906
Name MAPK14
Description mitogen activated protein kinase 14
Notes mitogen-activated protein kinase; involved in intracellular signalling, inhibition of apoptosis and gene activation [RGD]
RGD ID 70496
MGI ID 1346865
Cell Localization Nucleus
Pathway p38 MAPK
p38 Signaling
CREB signaling
AGTR1 -> ELK1-SRF signaling pathway
TNFRSF6 -> DDIT3 signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
EDG3/5 -> AP-1 signaling pathway
AGTR1 -> TP53 signaling pathway
AGTR2 -> CREB1 signaling pathway
TNFRSF6 -> RB1-E2F1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
VIPR1 -> CEBPB signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
AGTR2 -> TP53 signaling pathway
EGFR -> ATF2 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> TP53 signaling pathway
ERBB2/3 -> SP1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
EGFR/ERBB3 -> MEF2A signaling pathway
F2R -> AP-1 signaling pathway
EGFR/ERBB3 -> MEF2C signaling pathway
ENDRA -> AP-1 signaling pathway
ENDRA -> CREB1 signaling pathway
ENDRB -> AP-1 signaling pathway
F2R -> CREB1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
PTAFR -> AP-1 signaling pathway
PTAFR -> ATF1 signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
PTAFR -> NF-kB signaling pathway
IL1R -> NF-kB signaling pathway
ERBB2 -> ETV1 signaling pathway
CCR5 -> TP53 signaling pathway
CD28 -> ATF1 signaling pathway
CD28 -> ATF2 signaling pathway
CD28 -> CREB1 signaling pathway
TGFBR -> AP-1 signaling pathway
CD28 -> NF-kB signaling pathway
TGFBR -> ATF2 signaling pathway
TGFBR -> CREB1 signaling pathway
TGFBR -> ELK1-SRF signaling pathway
TGFBR -> ELK4-SRF signaling pathway
TGFBR -> GADD153 signaling pathway
TGFBR -> MAX signaling pathway
TGFBR -> MEF2A signaling pathway
TGFBR -> MEF2C signaling pathway
TGFBR -> TP53 signaling pathway
ITGB1 -> AP-1 signaling pathway
TLR2/4/5/7/9 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> NF-kB signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
TLR2/6 -> AP-1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KDR -> NFATC1 signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CNRs -> CREB1 signaling pathway
TNFRs -> AP-1 signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
GRM1/5 -> CREB1 signaling pathway
TNFRs -> ATF2 signaling pathway
TNFRs -> CREB1 signaling pathway
DDR1 -> NF-kB signaling pathway
TNFRs -> ELK1-SRF signaling pathway
TNFRs -> ELK4-SRF signaling pathway
TNFRs -> NF-kB signaling pathway
NGFR -> AP-1 signaling pathway
ICAM1 -> AP-1 signaling pathway
TNFRs -> TP53 signaling pathway
TNFRSF1A -> AP-1 signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> CREB1 signaling pathway
NGFR -> CEBPB signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
NGFR -> CREB1 signaling pathway
NGFR -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
NGFR -> ELK4-SRF signaling pathway
NGFR -> NF-kB signaling pathway
DRD2 -> CREB1 signaling pathway
NGFR -> TP53 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGTR1 -> CREB1 signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
TNFRSF5 -> RB1-E2F1 signaling pathway
EDARs -> NF-kB signaling pathway
Group Kinases
cell surface receptor linked signal transduction
protein kinase cascade
stress-activated MAPK cascade
positive regulation of erythrocyte differentiation
cell motility
DNA damage checkpoint
glucose metabolism
fatty acid oxidation
protein amino acid phosphorylation
protein amino acid autophosphorylation
positive regulation of transcription from RNA polymerase II promoter
angiogenesis
striated muscle development
antimicrobial humoral response (sensu Vertebrata)
response to stress
chemotaxis
cell
cytoplasm
cytosol
cytosolic part
nucleus
spindle pole
nucleotide binding
protein binding
ATP binding
protein C-terminus binding
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein-tyrosine kinase activity
MAP kinase activity
MP kinase activity
MAP kinase kinase activity
GenBank ID NC_000006
NM_139012
NP_620581
NM_139014
NP_620583
NM_001315
NP_001306
NM_139013
NP_620582
NT_007592
NW_923073
AC_000049
U19775
AAC50329
AB074150
BAB85654
AF100544
AAF36770
BC000092
AAH00092
BC031574
AAH31574
BT006933
AAP35579
CR536505
CAG38743
CR612713
L35263
AAA57455
L35264
AAA57456
Z25432
CAA80919
Q15454
Q16539
NC_000083
NM_011951
NP_036081
NT_039649
NT_165782
NW_000124
NW_001030605
AC_000039
AC170998
CT009661
AF128892
AAF34818
AF195850
AAF06348
AK089059
BAC40726
AK133684
BAE21782
AK151348
BAE30324
AK153025
BAE31659
AK177608
AK185139
AK210810
AK219197
BC012235
AAH12235
BC018227
BC085303
AAH85303
BG087465
D83073
BAA19741
U10871
AAA20888
X65067
CAA46200
P47811
Q5U421
NC_005119
NM_031020
NP_112282
NW_001084789
NW_047597
AC_000088
AF346293
AAK15541
BC092193
AAH92193
U73142
AAC71059
U91847
AAB51285
P70618
Q56A33
Source Curated
LocusLink ID 1432
26416
81649
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 600289
Alias RK
p38
EXIP
Mxi2
CSBP1
CSBP2
CSPB1
PRKM14
PRKM15
SAPK2A
p38ALPHA
mitogen-activated protein kinase 14
p38alpha Exip
p38 MAP kinase
MAP kinase Mxi2
Csaids binding protein
MAX-interacting protein 2
stress-activated protein kinase 2A
p38 mitogen activated protein kinase
cytokine suppressive anti-inflammatory drug binding protein
Crk1
p38MAPK
MGC102436
p38-alpha
mitogen activated protein kinase 14
tRNA synthetase cofactor p38
cytokine suppressive anti-inflammatory drug binding protein 1
Hog
CSBP
p38Hog
MGC105413
MAP kinase 2
reactive kinase
cytokine-supressive anti-inflammatory drug binding protein
GO ID 0005524
0004707
0004708
0008339
0000166
0005515
0004674
0016740
0019735
0006928
0007166
0006935
0006468
0007243
0006950
0005737
0005634
0016301
0004672
0004713
0000077
0001525
0019395
0006006
0045648
0045944
0007519
0005623
0000922
0008022
0046777
0051403
0005829
0044445
Swiss-Prot Accession Q15454
Q16539
P47811
Q5U421
P70618
Q56A33
Unigene ID Hs.588289
Mm.311337
Rn.88085