ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:9252:out-urn:agi-llid:1385::positive
Entities RPS6KA5 --+> CREB1
References 18
Connectivity 2
Effect positive
MedLine Reference 11701463:1152
Sentence Activated MSK1 phosphorylates CREB at Ser133.
Journal ATVB
Journal Reference v21 i11 p1764 (2001)
Journal Link http://atvb.ahajournals.org/cgi/content/full/21/11/1764
Organism rat
Source Curated
MedLine Reference 11907026:1243
Sentence MSK-1 phosphorylates CREB in response to FGF or NGF in PC12 cells.
Journal J. Biol. Chem
Journal Reference v277 i21 p18710 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/21/18710
CellLineName PC 12
Organism rat
Source Curated
MedLine Reference 12414794:1131
Sentence MSK1 has been shown to phosphorylate CREB and to be activated by EGF , as well as ERK1/2 and p38 MAPKs ( 27 ).
Journal J. Biol. Chem
Journal Reference v277 i52 p50550 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/52/50550
CellLineName HeLa
Organism mouse
Source Curated
MedLine Reference 9687510:1176
Sentence MSK1 phosphorylates CREB at Ser133. ( A ) Comparison of the substrate specificities of MSK1, MAPKAP-K1a and MAPKAP-K1b towards the indicated peptides and CREB.
Journal EMBO
Journal Reference v17 i15 p4426 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/15/4426
Organism mouse
Source Curated
MedLine Reference 12896977:1312
Sentence It is interesting to note that H89 is also a potent inhibitor of protein kinase A (PKA) and that both MSK1 and PKA can phosphorylate CREB.
Journal J. Biol. Chem
Journal Reference v278 i42 p41034 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/42/41034
Source Curated
CellType lymphocyte
MedLine Reference 12763014:6
CellLineName Rat2
Organism rat
Source Curated
CellType fibroblast
MedLine Reference 12808055:1375
Journal Mol. Biol. Cell
Journal Reference v14 i6 p2603 (2003)
Journal Link http://www.molbiolcell.org/cgi/content/full/14/6/2603
Source Curated
MedLine Reference 15496409:7
Organism mouse
Source Curated
CellType macrophage
MedLine Reference 12690113:1238
Journal J. Biol. Chem
Journal Reference v278 i26 p23243 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/26/23243
Tissue epithelia
Organ lung
Source Curated
MedLine Reference 11909979:1030
Journal Mol. Cell. Biol
Journal Reference v22 i8 p2871 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/8/2871
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 11123304:1030
Journal J. Immunol
Journal Reference v166 i1 p284 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/1/284
Organism mouse
Source Curated
MedLine Reference 10706690:1022
Journal J. Immunol
Journal Reference v164 i6 p3018 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/6/3018
CellLineName HeLa
Organism mouse
Source Curated
MedLine Reference 9873047:1126
Journal J. Biol. Chem
Journal Reference v274 i2 p1026 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/2/1026
Organ heart
Source Curated
MedLine Reference 3486717880
Sentence Previous Article | Next Article Cellular/Molecular Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins J.
Source Curated
MedLine Reference 12414794:1133
Sentence MSK1 has been shown to phosphorylate CREB and to be activated by EGF , as well as ERK1/2 and p38 MAPKs ( 27 ).
Journal J. Biol. Chem
Journal Reference v277 i52 p50550 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/52/50550
CellLineName HeLa
Organism Mus musculus
Source Curated
MedLine Reference 12690113:1233
Sentence Although CREB activation by MSK1 has been established by previous studies in other cells ( 37 ? 39 ), it has remained unclear in airway epithelial cells.
Journal J. Biol. Chem
Journal Reference v278 i26 p23243 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/26/23243
Tissue epithelia
Organ lung
Source Curated
MedLine Reference 11123304:1027
Sentence CREB is also directly phosphorylated by mitogen- and stress-activated kinase 1 ( 19 ), the kinase activated by stress stimuli in the p38 MAPK-dependent pathway or by growth factor in the ERK-dependent cascade.
Journal J. Immunol
Journal Reference v166 i1 p284 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/1/284
Organism Mus musculus
Source Curated
MedLine Reference 3330391288
Sentence Previous Article | Next Article Cellular/Molecular Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins J.
Source Curated