ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:1432:out-urn:agi-llid:9252::positive
Entities MAPK14 --+> RPS6KA5
References 12
Connectivity 2
Effect positive
MedLine Reference 12628924:1039
Sentence The nuclear kinase MSK1 is activated by both ERK and p38 MAPK.
Journal EMBO
Journal Reference v22 i6 p1313 (2003)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/22/6/1313
Organism mouse
Source Curated
MedLine Reference 11701463:1153
Sentence Suppression of ERK and p38 MAPK is required to suppress the activation of MSK1.
Journal ATVB
Journal Reference v21 i11 p1764 (2001)
Journal Link http://atvb.ahajournals.org/cgi/content/full/21/11/1764
Organism rat
Source Curated
MedLine Reference 12690113:1145
Sentence MSK1 is widely distributed in mammalian cells and can be activated by MAPK/ERK and SAPK2a/p38 ( 37 ?????? 39 ).
Journal J. Biol. Chem
Journal Reference v278 i26 p23243 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/26/23243
Source Curated
MedLine Reference 9873047:1016
Sentence Although purified recombinant RLPK can be phosphorylated by ERK2 and p38alpha in vitro , its activity is not affected by this phosphorylation.
Journal J. Biol. Chem
Journal Reference v274 i2 p1026 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/2/1026
CellLineName HeLa
Source Curated
MedLine Reference 12896977:1309
Sentence Although the p38 MAPK can activate mitogen and stress-activated protein kinase-1 (MSK1), a major histone H3 kinase ( 67 ), SB203580 shows no effect on histone H3 acetylation at the IL-2 promoter ( Fig. 9 D ).
Journal J. Biol. Chem
Journal Reference v278 i42 p41034 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/42/41034
Source Curated
CellType lymphocyte
MedLine Reference 12391245:1307
Journal J. Immunol
Journal Reference v169 i9 p5260 (2002)
Journal Link http://www.jimmunol.org/cgi/content/full/169/9/5260
CellLineName THP I
Organism mouse
Source Curated
MedLine Reference 10706690:1102
Journal J. Immunol
Journal Reference v164 i6 p3018 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/6/3018
Organism mouse
Source Curated
CellType macrophage
MedLine Reference 12562765:1200
Journal J. Biol. Chem
Journal Reference v278 i15 p12650 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/15/12650
CellLineName JB6
Source Curated
MedLine Reference 9873047:7
Sentence Although purified recombinant RLPK can be phosphorylated by ERK2 and p38alpha in vitro, its activity is not affected by this phosphorylation.
CellLineName HeLa
Source Curated
MedLine Reference 12690113:1232
Sentence MSK1 is known to be regulated by MAPK/ERK and SAPK2a/p38 and is currently the best candidate for the mediation of cytokine-induced CREB phosphorylation at Ser133 ( 37 ? 39 , 47 ).
Journal J. Biol. Chem
Journal Reference v278 i26 p23243 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/26/23243
Tissue epithelia
Organ lung
Source Curated
MedLine Reference 12896977:1308
Sentence Although the p38 MAPK can activate mitogen and stress-activated protein kinase-1 (MSK1), a major histone H3 kinase ( 67 ), SB203580 shows no effect on histone H3 acetylation at the IL-2 promoter ( Fig. 9 D ).
Journal J. Biol. Chem
Journal Reference v278 i42 p41034 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/42/41034
Source Curated
MedLine Reference 12391245:1311
Sentence Kinases such as MAPKAP kinases 2 and 3, p38-regulated/activated protein kinase, MAPK-interacting kinase-2, and mitogen- and stress-activated kinase-1 are activated by p38 MAPK under certain circumstances ( 66 , 70 , 71 , 72 , 73 ).
Journal J. Immunol
Journal Reference v169 i9 p5260 (2002)
Journal Link http://www.jimmunol.org/cgi/content/full/169/9/5260
Organism Mus musculus
Source Curated