ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-complex:3000112:out-urn:agi-llid:207::unknown
Entities Phosphatidylinositol 3-kinase ---> AKT1
References 68
Connectivity 2
Effect unknown
MedLine Reference 12097301:1220
Sentence PI3K is known to phosphorylate Akt to pAkt, which in turn phosphorylates GSK-3???? to pGSK-3???? (25) .
Journal Cancer Res
Journal Reference v62 i13 p3861 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/13/3861
Organism mouse
Source Curated
MedLine Reference 9973222:1193
Sentence Normally, PI3'K phosphorylates the serine-threonine protein kinase, Akt, and ribosomal S6 subunit kinase, p70 S6Rsk .
Journal Cancer Res
Journal Reference v59 i3 p711 (1999)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/59/3/711
CellLineName MOCK
Organism mouse
Source Curated
MedLine Reference 11454715:1177
Sentence However, R1881 does not prevent the blockade of AKT phosphorylation by PI3K inhibitors, although it does inhibit apoptosis, which suggests that there is an effect of R1881 on apoptosis downstream from AKT.
Journal Cancer Res
Journal Reference v61 i14 p5611 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/14/5611
CellLineName lncap
Source Curated
MedLine Reference 12907613:1187
Sentence Cells were lysed, and whole cell lysates were resolved by SDS-PAGE, transferred to Immobilon-P, and immunoblotted ( WB ) with the antibodies indicated ( C ) to examine inhibition of Akt phosphorylation by the PI3K inhibitor.
Journal Cancer Res
Journal Reference v63 i15 p4412 (2003)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/15/4412
Organism mouse
Source Curated
MedLine Reference 11289112:1194
Sentence We found that although the phosphorylation and, hence, the activity of Akt remain to be high or even increased instead of decreased in some of the tumor cells when they are cultured in suspension, inhibition of Akt phosphorylation by PI 3K specific inhibitors did not induce cell death, suggesting that the PI 3K-Akt pathway is not the major pathway or at least not the only pathway in mediating the cell survival signals from the tyrosine kinases in the tumor cells.
Journal Cancer Res
Journal Reference v61 i6 p2439 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/6/2439
Organism dog
Source Curated
MedLine Reference 12411472:1157
Journal Hypertension
Journal Reference v40 i5 p748 (2002)
Journal Link http://hyper.ahajournals.org/cgi/content/full/40/5/748
Organ aorta
Source Curated
MedLine Reference 11796503:1374
Journal Endocrinology
Journal Reference v143 i2 p492 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/143/2/492
CellLineName C2C12
Organism mouse
Organ liver
Source Curated
MedLine Reference 12586755:1043
Journal Endocrinology
Journal Reference v144 i3 p793 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/144/3/793
Organism rat
Source Curated
CellType granulosa
MedLine Reference 12021190:1248
Journal Endocrinology
Journal Reference v143 i6 p2259 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/143/6/2259
Organism rat
Source Curated
CellType granulosa
MedLine Reference 11796494:1167
Journal Endocrinology
Journal Reference v143 i2 p420 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/143/2/420
CellLineName MG 63
Source Curated
MedLine Reference 11416012:1161
Journal Endocrinology
Journal Reference v142 i7 p2921 (2001)
Journal Link http://endo.endojournals.org/cgi/content/full/142/7/2921
CellLineName FSH
Organism pig
Organ luteal
Source Curated
CellType granulosa
MedLine Reference 9710127:1015
Journal Circulation Res
Journal Reference v83 i3 p334 (1998)
Journal Link http://circres.ahajournals.org/cgi/content/full/83/3/334
Tissue endothelial
Organ vein
Source Curated
MedLine Reference 11440979:1170
Journal Circulation Res
Journal Reference v89 i1 p63 (2001)
Journal Link http://circres.ahajournals.org/cgi/content/full/89/1/63
Organism rat
Organ aorta
Source Curated
MedLine Reference 10783307:1200
Journal Carcinogenesis
Journal Reference v21 i5 p881 (2000)
Journal Link http://carcin.oupjournals.org/cgi/content/full/21/5/881
CellLineName MCF10A
Source Curated
MedLine Reference 11156413:1240
Journal Cancer Res
Journal Reference v60 i24 p7066 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/24/7066
Organism mouse
Source Curated
MedLine Reference 10728713:1024
Journal Cancer Res
Journal Reference v60 i5 p1457 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/5/1457
Tissue laryngea
Source Curated
MedLine Reference 11741913:1142
Journal J. Biol. Chem
Journal Reference v277 i8 p6254 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/8/6254
CellLineName Ba/F3
Organism mouse
Source Curated
MedLine Reference 11719508:1142
Journal J. Biol. Chem
Journal Reference v277 i5 p3101 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/5/3101
Organism pig
Tissue endothelial
Source Curated
CellType fibroblast
MedLine Reference 11551934:1141
Journal J. Biol. Chem
Journal Reference v276 i50 p47563 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/50/47563
CellLineName HT 29
Organism mouse
Source Curated
MedLine Reference 11495916:1112
Journal J. Biol. Chem
Journal Reference v276 i40 p37436 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/40/37436
Source Curated
MedLine Reference 11479295:1168
Journal J. Biol. Chem
Journal Reference v276 i38 p35693 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/38/35693
Organism mouse
Tissue alveola
Source Curated
MedLine Reference 11438521:1113
Journal J. Biol. Chem
Journal Reference v276 i35 p32779 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/35/32779
Organism rat
Source Curated
MedLine Reference 11278584:1219
Journal J. Biol. Chem
Journal Reference v276 i15 p12466 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/15/12466
CellLineName C2C12
Organism mouse
Source Curated
CellType myoblast
MedLine Reference 10601276:1119
Journal J. Biol. Chem
Journal Reference v274 i52 p37147 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/52/37147
Organism pig
Source Curated
MedLine Reference 12954639:1173
Journal J. Biol. Chem
Journal Reference v278 i46 p45101 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/46/45101
CellLineName Hep 3B
Organism rat
Source Curated
MedLine Reference 12947088:1250
Journal J. Biol. Chem
Journal Reference v278 i45 p44608 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/45/44608
CellLineName HT 29
Source Curated
MedLine Reference 12670949:1170
Journal J. Biol. Chem
Journal Reference v278 i23 p20681 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/23/20681
Source Curated
MedLine Reference 12595524:1202
Journal J. Biol. Chem
Journal Reference v278 i19 p16494 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/19/16494
Source Curated
MedLine Reference 12488318:1317
Journal J. Biol. Chem
Journal Reference v278 i8 p5871 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/8/5871
CellLineName nmumg
Organism mouse
Tissue epithelia
Source Curated
MedLine Reference 11864976:1238
Journal J. Biol. Chem
Journal Reference v277 i19 p16547 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/19/16547
CellLineName L 929
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 10849422:1184
Journal J. Biol. Chem
Journal Reference v275 i33 p25572 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/33/25572
Organism mouse
Source Curated
CellType spermatogone
MedLine Reference 10807918:1138
Journal J. Biol. Chem
Journal Reference v275 i29 p22583 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/29/22583
CellLineName COS-7
Source Curated
Journal J. Cell Biol
Journal Reference v159 i1 p13-a (2002)
Journal Link http://www.jcb.org/cgi/content/full/159/1/13-a
Tissue blood
Source Curated
Journal J. Cell Biol
Journal Reference v159 i1 p13-a (2002)
Journal Link http://www.jcb.org/cgi/content/full/159/1/13-a
Tissue blood
Source Curated
MedLine Reference 15284297:6
Organism rat
Tissue epithelia
Source Curated
MedLine Reference 11758779:6
Source Curated
CellType neural
MedLine Reference 10024371:1149
Journal J. Neurosci
Journal Reference v19 i5 p1876 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/5/1876
Organism rat
Source Curated
CellType neural
MedLine Reference 10024343:1102
Journal J. Neurosci
Journal Reference v19 i5 p1557 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/5/1557
Organism drosophila
Source Curated
MedLine Reference 10037498:1018
Journal J. Neurochem
Journal Reference v72 i3 p1250 (1999)
Journal Link http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jnc
Organ cerebellar
Source Curated
CellType neural
MedLine Reference 11390502:1199
Journal J. Immunol
Journal Reference v166 i12 p7486 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/12/7486
CellLineName BaF3
Source Curated
MedLine Reference 11160204:1253
Journal J. Immunol
Journal Reference v166 i3 p1627 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/3/1627
CellLineName RBL
Organism rat
Source Curated
MedLine Reference 10754327:1105
Journal J. Immunol
Journal Reference v164 i8 p4286 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/8/4286
Source Curated
MedLine Reference 10438924:1268
Journal J. Immunol
Journal Reference v163 i4 p1894 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/4/1894
Organism mouse
Source Curated
MedLine Reference 12865424:1164
Journal J. Biol. Chem
Journal Reference v278 i39 p37041 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/39/37041
CellLineName RAW264.7
Organism mouse
Source Curated
MedLine Reference 12819192:1300
Journal J. Biol. Chem
Journal Reference v278 i35 p33011 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/35/33011
Organism mouse
Source Curated
MedLine Reference 12464621:1017
Journal J. Biol. Chem
Journal Reference v278 i8 p5837 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/8/5837
Organism mouse
Source Curated
CellType hepatocyte
MedLine Reference 12082100:1200
Journal J. Biol. Chem
Journal Reference v277 i35 p31601 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/35/31601
CellLineName KO
Organism mouse
Source Curated
MedLine Reference 11978789:1050
Journal J. Biol. Chem
Journal Reference v277 i28 p24896 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/28/24896
CellLineName BHK
Organism rat
Source Curated
CellType fibroblast
MedLine Reference 11125027:1121
Journal Mol. Pharm
Journal Reference v59 i1 p76 (2001)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/59/1/76
CellLineName H3
Organism rat
Source Curated
MedLine Reference 10935551:1272
Journal Mol. Endocrin
Journal Reference v14 i8 p1283 (2000)
Journal Link http://mend.endojournals.org/cgi/content/full/14/8/1283
CellLineName FSH
Organism rat
Source Curated
CellType granulosa
MedLine Reference 11027277:1285
Journal Mol. Cell. Biol
Journal Reference v20 i21 p8069 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/21/8069
CellLineName PC 12
Organism rat
Source Curated
MedLine Reference 15471896:6
CellLineName SK-OV-3
Source Curated
MedLine Reference 15385613:5
CellLineName DRG
Organism rat
Source Curated
CellType neural
MedLine Reference 15235108:1
Source Curated
MedLine Reference 14559356:5
CellLineName PC 12
Organism bovine
Source Curated
MedLine Reference 13679036:5
CellLineName VSMC
Organism rat
Tissue smooth muscle
Source Curated
MedLine Reference 12941905:3
CellLineName NIH 3T3
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 12610654:5
Organism rat
Organ hippocampal
Source Curated
MedLine Reference 12198247:5
CellLineName PC12w
Organism rat
Source Curated
MedLine Reference 11991736:2
Organism rat
Organ heart
Source Curated
CellType myocyte
MedLine Reference 11792567:7
Organism mouse
Source Curated
CellType osteoclast
MedLine Reference 11563846:6
CellLineName VSMC
Organism rat
Organ aorta
Source Curated
MedLine Reference 10212287:8
Organism rat
Organ cerebellar
Source Curated
CellType neural
MedLine Reference 15336230:3
Organ amnion
Source Curated
MedLine Reference 12738898:1123
Journal Stroke
Journal Reference v34 i6 p1513 (2003)
Journal Link http://stroke.ahajournals.org/cgi/content/full/34/6/1513
Organism mouse
Tissue cortex
Organ brain
Source Curated
MedLine Reference 12417757:1193
Journal PNAS
Journal Reference v99 i23 p14925 (2002)
Journal Link http://www.pnas.org/cgi/content/full/99/23/14925
CellLineName A1
Source Curated
MedLine Reference 11562448:1277
Journal Mol. Pharm
Journal Reference v60 i4 p847 (2001)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/60/4/847
Organism rat
Source Curated
CellType neural
MedLine Reference 12181443:1223
Journal Mol. Pharm
Journal Reference v62 i3 p660 (2002)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/62/3/660
CellLineName Hey
Source Curated