Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:6654:out-urn:agi-llid:3265::positive
Entities SOS1 --+> HRAS
References 14
Connectivity 2
MedLine Reference 8063737:0
Sentence Shc, grb2, and Son-of-sevenless (mSos1) proteins are potential upstream regulators of p21ras.
Organism Rattus norvegicus
MedLine Reference 11842308:7
Sentence This was associated with a low expression of the p21Ras stimulatory element human son of sevenless (hSOS1) but normally expressed p21Ras inhibitory element p120GTPase-activating protein.
Tissue lymph
MedLine Reference 11560935:3
Sentence Although both Sos1 and Ras-GRF1 activate the Ras proteins Ha-Ras, N-Ras, and Ki-Ras, only Ras-GRF1 also activates the functionally distinct R-Ras GTPase.
Organ brain
CellType neural
MedLine Reference 10499523:10069
Journal Endocrinology
Journal Reference v140 i10 p4659
Journal Link http://endo.endojournals.org/cgi/content/full/140/10/4659
Organism Mus musculus
MedLine Reference 9223336:10022
Journal PNAS
Journal Reference v94 i15 p8185
Journal Link http://www.pnas.org/cgi/content/full/94/15/8185
Organism Rattus norvegicus
MedLine Reference 9388270:10026
Journal J. Biol. Chem
Journal Reference v272 i49 p31163
Journal Link http://www.jbc.org/cgi/content/full/272/49/31163
MedLine Reference 11278444:10081
Journal J. Biol. Chem
Journal Reference v276 i24 p21521
Journal Link http://www.jbc.org/cgi/content/full/276/24/21521
Organism Rattus norvegicus
MedLine Reference 12169433:10097
Journal Endocrin. Metabol
Journal Reference v283 i3 pE413
Journal Link http://ajpendo.physiology.org/cgi/content/full/283/3/E413
MedLine Reference 14749369:10237
Journal Mol. Cell. Biol
Journal Reference v24 i4 p1516
Journal Link http://mcb.asm.org/cgi/content/full/24/4/1516
Organism Rattus norvegicus
MedLine Reference 15226433:10183
Journal Mol. Cell. Biol
Journal Reference v24 i14 p6311
Journal Link http://mcb.asm.org/cgi/content/full/24/14/6311
Organism Mus musculus
MedLine Reference 10347197:10286
Journal J. Biol. Chem
Journal Reference v274 i23 p16377
Journal Link http://www.jbc.org/cgi/content/full/274/23/16377
Organism Mus musculus
MedLine Reference 9712046:10027
Journal J. Immunol
Journal Reference v161 i4 p1795
Journal Link http://www.jimmunol.org/cgi/content/full/161/4/1795
Organism Mus musculus
MedLine Reference 14517341:10103
Journal Mol. Cancer Res
Journal Reference v1 i11 p789
Journal Link http://mcr.aacrjournals.org/cgi/content/full/1/11/789
MedLine Reference 14749369:1233
Sentence Activation of the Met receptor by HGF/SF leads to recruitment of Grb2 and Sos1 to the receptor, thereby activating Ha-Ras and c-Raf.
Source Curated