Regulation :

Effect unknown
Mechanism phosphorylation
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:3265:out-urn:agi-llid:5595::unknown:phosphorylation
Entities HRAS ---> MAPK3
References 55
Connectivity 2
MedLine Reference 15598443:2
Sentence H-ras-mediated activation of p38 MAPK and ERK-1/2 was stimulated by TGF-beta.
CellLineName MCF10A
MedLine Reference 10340467:11
Sentence Elevated Erk1/2 activity in ECV304 cells was suppressed by dominant negative H-Ras, but not by cytochalasin D.
CellLineName ECV 304
MedLine Reference 12220617:5
Sentence Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by SP and PDGF-BB.
MedLine Reference 12464615:10250
Journal J. Biol. Chem
Journal Reference v278 i6 p3606
Journal Link http://www.jbc.org/cgi/content/full/278/6/3606
MedLine Reference 12477973:15
Organism Mus musculus
MedLine Reference 14638694:10289
Journal J. Biol. Chem
Journal Reference v279 i7 p5837
Journal Link http://www.jbc.org/cgi/content/full/279/7/5837
Organism Mus musculus
MedLine Reference 11567984:10169
Journal Blood
Journal Reference v98 i7 p2014
Journal Link http://www.bloodjournal.org/cgi/content/full/98/7/2014
MedLine Reference 14560030:10149
Journal Mol. Cell. Biol
Journal Reference v23 i21 p7875
Journal Link http://mcb.asm.org/cgi/content/full/23/21/7875
MedLine Reference 9030581:10207
Journal J. Biol. Chem
Journal Reference v272 i8 p5141
Journal Link http://www.jbc.org/cgi/content/full/272/8/5141
MedLine Reference 11495721:8
Tissue smooth muscle
Organ trachea
Organism Mus musculus
MedLine Reference 12595757:7
Tissue smooth muscle
Organism Rattus norvegicus
CellLineName VSMCs
MedLine Reference 10952668:10
Organism Mus musculus
MedLine Reference 11812655:5
Organism Mus musculus
MedLine Reference 8090223:2
Organism Mus musculus
MedLine Reference 9180263:4
Organism Rattus norvegicus
CellLineName C6
MedLine Reference 14500381:3
MedLine Reference 131102972:11024
MedLine Reference 131101971:11207
MedLine Reference 10666084:10021
Journal Heart Circul
Journal Reference v278 i2 pH521
Journal Link http://ajpheart.physiology.org/cgi/content/full/278/2/H521
Organism Mus musculus
MedLine Reference 15853814:10132
Journal Eur. J. Biochem
Journal Reference v272 i9 p2304
Journal Link http://content.febsjournal.org/cgi/content/full/272/9/2304
Organism Mus musculus
MedLine Reference 12134066:10214
Journal Mol. Biol. Cell
Journal Reference v13 i7 p2256
Journal Link http://www.molbiolcell.org/cgi/content/full/13/7/2256
MedLine Reference 12783880:10061
Journal J. Biol. Chem
Journal Reference v278 i35 p32517
Journal Link http://www.jbc.org/cgi/content/full/278/35/32517
Organism Rattus norvegicus
MedLine Reference 15319437:10233
Journal J. Biol. Chem
Journal Reference v279 i45 p46497
Journal Link http://www.jbc.org/cgi/content/full/279/45/46497
Organism Rattus norvegicus
MedLine Reference 9862707:10127
Journal J. Immunol
Journal Reference v161 i12 p6768
Journal Link http://www.jimmunol.org/cgi/content/full/161/12/6768
MedLine Reference 12746290:10171
Journal Endocrinology
Journal Reference v144 i6 p2304
Journal Link http://endo.endojournals.org/cgi/content/full/144/6/2304
Organism Mus musculus
MedLine Reference 15860728:10142
Journal Cell Sci
Journal Reference v118 i9 p1799
Journal Link http://jcs.biologists.org/cgi/content/full/118/9/1799
Organism Mus musculus
MedLine Reference 11159826:10027
Journal Endocrinology
Journal Reference v142 i2 p564
Journal Link http://endo.endojournals.org/cgi/content/full/142/2/564
Organism Mus musculus
MedLine Reference 14988413:10216
Journal J. Biol. Chem
Journal Reference v279 i19 p20345
Journal Link http://www.jbc.org/cgi/content/full/279/19/20345
Organism Mus musculus
MedLine Reference 9235901:10045
Journal J. Biol. Chem
Journal Reference v272 i31 p19125
Journal Link http://www.jbc.org/cgi/content/full/272/31/19125
Organism Rattus norvegicus
MedLine Reference 9584148:10175
Journal J. Exp. Med
Journal Reference v187 i10 p1699
Journal Link http://www.jem.org/cgi/content/full/187/10/1699
Organism Mus musculus
MedLine Reference 11809805:10151
Journal Mol. Cell. Biol
Journal Reference v22 i4 p1140
Journal Link http://mcb.asm.org/cgi/content/full/22/4/1140
Organism Mus musculus
MedLine Reference 12839994:1194
Sentence This effect is specific for the Rac1 pathway, because cytochalasin D does not interfere with the activation of Erk1 induced by the H-ras oncogene product (Figure 7 B).
Journal EMBO
Journal Reference v22 i13 p3326 (2003)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/22/13/3326
Source Curated
CellLineName COS I
MedLine Reference 10969813:1168
Sentence Tumors with mutant p21 ras also had increased ERK-1 and ERK-2 activation, 156 ???± 15% and 223 ???± 8% above that of ERK-1 and ERK-2 from tumors with wild-type nonactivated p21 ras ( n = 4; P < 0.05), respectively.
Journal Cancer Res
Journal Reference v60 i16 p4602 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/16/4602
Organism rat
Source Curated
MedLine Reference 9516156:1206
Sentence Wortmannin is a specific inhibitor of PI3K at nanomolar concentrations, 44 while PD098059 has been recently described as a specific inhibitor of MEK, a kinase mediating activation of ERK1/ERK2 by p21ras. 47 , 48 Addition of opsonized particles (serum-treated zymosan, STZ) to eosinophils results in activation of the respiratory burst.
Journal Blood
Journal Reference v91 i7 p2547 (1998)
Journal Link http://www.bloodjournal.org/cgi/content/full/91/7/2547
Source Curated
CellType eosinophil
MedLine Reference 10845855:1162
Sentence The impact of inhibition of tyrosine phosphatases by thiol redox processes would be to cause an apparent enhancement of upstream protein kinase??????linked signaling systems that are partially activated under physiological or pathophysiological conditions. 82 In addition, there is evidence that oxidant mechanisms may stimulate increases in the autophosphorylation of receptor-linked tyrosine kinases that activate the MAPK pathways, 83 and H 2 O 2 has been observed to stimulate tyrosine phosphorylation of the epidermal growth factor receptor in VSM cells, 84 whereas nitrosation of a thiol on p21 ras stimulates the activation of p42/p44 MAPK. 43 One area that is very poorly understood is how individual ROS and RNS influence the balance between the activities of the MAPK pathways.
Journal ATVB
Journal Reference v20 i6 p1430 (2000)
Journal Link http://atvb.ahajournals.org/cgi/content/full/20/6/1430
Source Curated
CellLineName VSM
MedLine Reference 11158240:1127
Tissue nerve
Journal J. Neurochem
Journal Reference v76 i3 p703 (2001)
Journal Link http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jnc
Organ nervous system
Organism mouse
Source Curated
MedLine Reference 9862707:1125
Journal J. Immunol
Journal Reference v161 i12 p6768 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/161/12/6768
Source Curated
CellType eosinophil
MedLine Reference 12464615:1244
Journal J. Biol. Chem
Journal Reference v278 i6 p3606 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/6/3606
Source Curated
CellLineName ng108-15
MedLine Reference 10801808:1277
Journal J. Biol. Chem
Journal Reference v275 i31 p23559 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/31/23559
Organism rat
Source Curated
MedLine Reference 9705357:1228
Journal J. Biol. Chem
Journal Reference v273 i34 p22120 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/34/22120
Organism rat
Source Curated
MedLine Reference 9235901:1125
Journal J. Biol. Chem
Journal Reference v272 i31 p19125 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/31/19125
Organism rat
Source Curated
CellLineName HEK 293
MedLine Reference 9030581:1204
Journal J. Biol. Chem
Journal Reference v272 i8 p5141 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/8/5141
Source Curated
CellLineName COS-7
MedLine Reference 8910287:1014
Journal J. Biol. Chem
Journal Reference v271 i44 p27205 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/44/27205
Organism mouse
Source Curated
CellLineName COS-7
MedLine Reference 10666084:1116
Journal Heart Circul
Journal Reference v278 i2 pH521 (2000)
Journal Link http://ajpheart.physiology.org/cgi/content/full/278/2/H521
Organism rat
Source Curated
MedLine Reference 12746290:1172
Journal Endocrinology
Journal Reference v144 i6 p2304 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/144/6/2304
Organism rat
Source Curated
MedLine Reference 11159826:1027
Journal Endocrinology
Journal Reference v142 i2 p564 (2001)
Journal Link http://endo.endojournals.org/cgi/content/full/142/2/564
Organ gastric
Organism rat
Source Curated
MedLine Reference 14560030:1149
Journal Mol. Cell. Biol
Journal Reference v23 i21 p7875 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/21/7875
Source Curated
MedLine Reference 12134066:1214
Journal Mol. Biol. Cell
Journal Reference v13 i7 p2256 (2002)
Journal Link http://www.molbiolcell.org/cgi/content/full/13/7/2256
Source Curated
MedLine Reference 9584148:1174
Journal J. Exp. Med
Journal Reference v187 i10 p1699 (1998)
Journal Link http://www.jem.org/cgi/content/full/187/10/1699
Organism mouse
Source Curated
Journal Cell
Journal Reference v88 i4 p521 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/4/521
Source Curated
CellLineName PY
MedLine Reference 11567984:1169
Journal Blood
Journal Reference v98 i7 p2014 (2001)
Journal Link http://www.bloodjournal.org/cgi/content/full/98/7/2014
Source Curated
CellType eosinophil
MedLine Reference 11809805:1151
Journal Mol. Cell. Biol
Journal Reference v22 i4 p1140 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/4/1140
Organism mouse
Source Curated
CellLineName MM14
MedLine Reference 11102500:1208
Journal J. Neurosci
Journal Reference v20 i23 p8902 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/23/8902
Organism rat
Source Curated
CellLineName PC 12
Source Curated
CellLineName PC 12
MedLine Reference 2167477899
Sentence Raf-1 is a downstream effector of H-Ras that induces the activation of the ERK1/ERK2 MAP kinases ( Howe et al., 1992 ).
Journal Cell
Journal Reference v88 i4 p521 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/4/521
Source Curated
CellLineName PY