Regulation :


Effect	positive
Mechanism	phosphorylation
Owner	Public
URN	urn:agi-Regulation:inout-urn:agi-llid:3265:out-urn:agi-llid:5594::positive:phosphorylation
Entities	HRAS --+> MAPK1
References	109
Connectivity	2


MedLine Reference	8378086:5
Sentence	In all cases, expression of p21ras(Asn-17) completely blocked signalling to ERK2.
Organism	Mus musculus
CellLineName	NIH 3T3


MedLine Reference	15598443:2
Sentence	H-ras-mediated activation of p38 MAPK and ERK-1/2 was stimulated by TGF-beta.
CellLineName	MCF10A


MedLine Reference	8376929:2
Sentence	In this study, we show that p21ras is a component of the TCR signaling pathway that controls ERK2 activation.
CellType	t cell


MedLine Reference	11988737:3
Organism	Mus musculus
CellType	fibroblast


MedLine Reference	16339563:6
CellType	macrophage


MedLine Reference	8246947:6
Organism	Rattus norvegicus
CellLineName	Swiss 3T3


MedLine Reference	15677464:6


MedLine Reference	9484798:1
Tissue	lymph


MedLine Reference	8090223:2
Organism	Mus musculus


MedLine Reference	9180263:4
Organism	Rattus norvegicus
CellLineName	C6


MedLine Reference	10340949:1
Organ	trachea
Organism	Mus musculus
CellType	myocyte


MedLine Reference	14500381:3


MedLine Reference	9484987:4
Tissue	endothelial
Organ	aorta


MedLine Reference	10340467:11
CellLineName	ECV 304


MedLine Reference	9351826:4
Tissue	mesangia
Organism	Rattus norvegicus
CellType	glomerular


MedLine Reference	8570170:7
Tissue	neuroectoderm
CellLineName	sk-n-mc


MedLine Reference	16014375:10375
Journal	Cell Sci
Journal Reference	v118 i15 p3263
Journal Link	http://jcs.biologists.org/cgi/content/full/118/15/3263
Organism	Mus musculus


MedLine Reference	11799108:10185
Journal	J. Biol. Chem
Journal Reference	v277 i13 p10813
Journal Link	http://www.jbc.org/cgi/content/full/277/13/10813
Organism	Mus musculus


MedLine Reference	12839928:10267
Journal	Cancer Res
Journal Reference	v63 i13 p3473
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/63/13/3473


MedLine Reference	16103083:10249
Journal	Cancer Res
Journal Reference	v65 i16 p7320
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/65/16/7320
Organism	Mus musculus


MedLine Reference	15238360:10331
Journal	Cell Phys
Journal Reference	v287 i2 p449
Journal Link	http://ajpcell.physiology.org/cgi/content/full/287/2/C449
Organism	Mus musculus


MedLine Reference	12902401:10200
Journal	Cell Sci
Journal Reference	v116 i18 p3835
Journal Link	http://jcs.biologists.org/cgi/content/full/116/18/3835


MedLine Reference	14638694:10289
Journal	J. Biol. Chem
Journal Reference	v279 i7 p5837
Journal Link	http://www.jbc.org/cgi/content/full/279/7/5837
Organism	Mus musculus


MedLine Reference	11457834:10190
Journal	J. Biol. Chem
Journal Reference	v276 i37 p34617
Journal Link	http://www.jbc.org/cgi/content/full/276/37/34617


MedLine Reference	11598192:10113
Journal	Mol. Biol. Cell
Journal Reference	v12 i10 p3074
Journal Link	http://www.molbiolcell.org/cgi/content/full/12/10/3074


MedLine Reference	11567984:10169
Journal	Blood
Journal Reference	v98 i7 p2014
Journal Link	http://www.bloodjournal.org/cgi/content/full/98/7/2014


MedLine Reference	10344756:10202
Journal	Cancer Res
Journal Reference	v59 i10 p2445
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/59/10/2445


MedLine Reference	15210703:10340
Journal	J. Biol. Chem
Journal Reference	v279 i36 p37398
Journal Link	http://www.jbc.org/cgi/content/full/279/36/37398
Organism	Mus musculus


MedLine Reference	9516156:10188
Journal	Blood
Journal Reference	v91 i7 p2547
Journal Link	http://www.bloodjournal.org/cgi/content/full/91/7/2547


MedLine Reference	14560030:10149
Journal	Mol. Cell. Biol
Journal Reference	v23 i21 p7875
Journal Link	http://mcb.asm.org/cgi/content/full/23/21/7875


MedLine Reference	11901221:6
Organ	kidney
CellLineName	293


MedLine Reference	8397201:3
Organism	Mus musculus
CellLineName	COS-M6


MedLine Reference	15319437:10233
Journal	J. Biol. Chem
Journal Reference	v279 i45 p46497
Journal Link	http://www.jbc.org/cgi/content/full/279/45/46497
Organism	Rattus norvegicus


MedLine Reference	9862707:10127
Journal	J. Immunol
Journal Reference	v161 i12 p6768
Journal Link	http://www.jimmunol.org/cgi/content/full/161/12/6768


MedLine Reference	12746290:10171
Journal	Endocrinology
Journal Reference	v144 i6 p2304
Journal Link	http://endo.endojournals.org/cgi/content/full/144/6/2304
Organism	Mus musculus


MedLine Reference	16000370:10183
Journal	Mol. Biol. Cell
Journal Reference	v16 i9 p4454
Journal Link	http://www.molbiolcell.org/cgi/content/full/16/9/4454
Organism	Mus musculus


MedLine Reference	15860728:10142
Journal	Cell Sci
Journal Reference	v118 i9 p1799
Journal Link	http://jcs.biologists.org/cgi/content/full/118/9/1799
Organism	Mus musculus


MedLine Reference	11159826:10027
Journal	Endocrinology
Journal Reference	v142 i2 p564
Journal Link	http://endo.endojournals.org/cgi/content/full/142/2/564
Organism	Mus musculus


MedLine Reference	15888452:10184
Journal	J. Biol. Chem
Journal Reference	v280 i26 p24524
Journal Link	http://www.jbc.org/cgi/content/full/280/26/24524


MedLine Reference	14988413:10216
Journal	J. Biol. Chem
Journal Reference	v279 i19 p20345
Journal Link	http://www.jbc.org/cgi/content/full/279/19/20345
Organism	Mus musculus


MedLine Reference	12481409:10149
Journal	Mol. Cancer Ther
Journal Reference	v1 i11 p885
Journal Link	http://mct.aacrjournals.org/cgi/content/full/1/11/885
Organism	Rattus norvegicus


MedLine Reference	9495809:10230
Journal	Mol. Pharm
Journal Reference	v53 i3 p438
Journal Link	http://molpharm.aspetjournals.org/cgi/content/full/53/3/438
Organism	Rattus norvegicus


MedLine Reference	11287623:10128
Journal	Mol. Cell. Biol
Journal Reference	v21 i9 p3192
Journal Link	http://mcb.asm.org/cgi/content/full/21/9/3192
Organism	Mus musculus


MedLine Reference	9235901:10045
Journal	J. Biol. Chem
Journal Reference	v272 i31 p19125
Journal Link	http://www.jbc.org/cgi/content/full/272/31/19125
Organism	Rattus norvegicus


MedLine Reference	9584148:10175
Journal	J. Exp. Med
Journal Reference	v187 i10 p1699
Journal Link	http://www.jem.org/cgi/content/full/187/10/1699
Organism	Mus musculus


MedLine Reference	15166036:10031
Journal	Blood
Journal Reference	v104 i6 p1679
Journal Link	http://www.bloodjournal.org/cgi/content/full/104/6/1679
Organism	Mus musculus


MedLine Reference	11278444:10254
Journal	J. Biol. Chem
Journal Reference	v276 i24 p21521
Journal Link	http://www.jbc.org/cgi/content/full/276/24/21521
Organism	Rattus norvegicus


MedLine Reference	12477973:15
Organism	Mus musculus


MedLine Reference	131102972:11024


MedLine Reference	131103555:11116


MedLine Reference	110001934:11017
Journal	J. Cell Biol
Journal Reference	v157 i3 p346
Journal Link	http://www.jcb.org/cgi/content/full/157/3/346


MedLine Reference	101000558:11122
Journal	Cell
Journal Reference	v88 i4 p521
Journal Link	http://www.cell.com/cgi/content/full/88/4/521


MedLine Reference	10666084:10021
Journal	Heart Circul
Journal Reference	v278 i2 pH521
Journal Link	http://ajpheart.physiology.org/cgi/content/full/278/2/H521
Organism	Mus musculus


MedLine Reference	15853814:10132
Journal	Eur. J. Biochem
Journal Reference	v272 i9 p2304
Journal Link	http://content.febsjournal.org/cgi/content/full/272/9/2304
Organism	Mus musculus


MedLine Reference	12134066:10214
Journal	Mol. Biol. Cell
Journal Reference	v13 i7 p2256
Journal Link	http://www.molbiolcell.org/cgi/content/full/13/7/2256


MedLine Reference	11123330:10189
Journal	J. Immunol
Journal Reference	v166 i1 p506
Journal Link	http://www.jimmunol.org/cgi/content/full/166/1/506


MedLine Reference	10899904:10277
Journal	J. Exp. Med
Journal Reference	v192 i2 p171
Journal Link	http://www.jem.org/cgi/content/full/192/2/171
Organism	Mus musculus


MedLine Reference	8617731:10152
Journal	J. Biol. Chem
Journal Reference	v271 i9 p4671
Journal Link	http://www.jbc.org/cgi/content/full/271/9/4671
Organism	Rattus norvegicus


MedLine Reference	12783880:10061
Journal	J. Biol. Chem
Journal Reference	v278 i35 p32517
Journal Link	http://www.jbc.org/cgi/content/full/278/35/32517
Organism	Rattus norvegicus


MedLine Reference	11533045:10275
Journal	J. Biol. Chem
Journal Reference	v276 i44 p40968
Journal Link	http://www.jbc.org/cgi/content/full/276/44/40968


MedLine Reference	11567984:1169
Sentence	However, Tat-dn-H-Ras did block ERK 1 and ERK 2 activation (Figure 7 B, lane 4) in these same cells.
Journal	Blood
Journal Reference	v98 i7 p2014 (2001)
Journal Link	http://www.bloodjournal.org/cgi/content/full/98/7/2014
Source	Curated
CellType	eosinophil


MedLine Reference	12902401:1198
Sentence	EGFP-RhoA(T19N) and EGFP-H-Ras(S17N) inhibited LPA-induced ERK activation by approximately 70% and 60%, respectively.
Journal	Cell Sci
Journal Reference	v116 i18 p3835 (1997)
Journal Link	http://jcs.biologists.org/cgi/content/full/116/18/3835
Source	Curated
CellLineName	PANC1


MedLine Reference	12746290:1172
Journal	Endocrinology
Journal Reference	v144 i6 p2304 (1997)
Journal Link	http://endo.endojournals.org/cgi/content/full/144/6/2304
Organism	rat
Source	Curated


MedLine Reference	11159826:1027
Journal	Endocrinology
Journal Reference	v142 i2 p564 (2001)
Journal Link	http://endo.endojournals.org/cgi/content/full/142/2/564
Organ	gastric
Organism	rat
Source	Curated


MedLine Reference	9351826:1007
Tissue	mesangia
Journal	EMBO
Journal Reference	v16 i21 p6439 (1997)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/16/21/6439
Organism	rat
Source	Curated
CellType	glomerular


Journal	Cell
Journal Reference	v88 i4 p521 (1997)
Journal Link	http://www.cell.com/cgi/content/full/88/4/521
Source	Curated
CellLineName	PY


Journal	Cell
Journal Reference	v88 i4 p521 (1997)
Journal Link	http://www.cell.com/cgi/content/full/88/4/521
Source	Curated
CellLineName	PY


Journal	Cell
Journal Reference	v86 i2 p243 (1996)
Journal Link	http://www.cell.com/cgi/content/full/86/2/243
Source	Curated
CellType	t cell


MedLine Reference	10969813:1168
Journal	Cancer Res
Journal Reference	v60 i16 p4602 (2000)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/60/16/4602
Organism	rat
Source	Curated


MedLine Reference	10344756:1191
Journal	Cancer Res
Journal Reference	v59 i10 p2445 (1999)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/59/10/2445
Source	Curated
CellLineName	HCT 116


MedLine Reference	9516156:1206
Journal	Blood
Journal Reference	v91 i7 p2547 (1998)
Journal Link	http://www.bloodjournal.org/cgi/content/full/91/7/2547
Source	Curated
CellType	eosinophil


MedLine Reference	10340949:1013
Journal	AJRCMB
Journal Reference	v20 i6 p1294 (1999)
Journal Link	http://ajrcmb.atsjournals.org/cgi/content/full/20/6/1294
Organ	trachea
Organism	bovine
Source	Curated
CellType	myocyte


MedLine Reference	8376929:3
Source	Curated
CellType	t cell
CellLineName	JURKAT


MedLine Reference	11158240:1127
Tissue	nerve
Journal	J. Neurochem
Journal Reference	v76 i3 p703 (2001)
Journal Link	http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jnc
Organ	nervous system
Organism	mouse
Source	Curated


MedLine Reference	9862707:1125
Journal	J. Immunol
Journal Reference	v161 i12 p6768 (1998)
Journal Link	http://www.jimmunol.org/cgi/content/full/161/12/6768
Source	Curated
CellType	eosinophil


MedLine Reference	10490980:1020
Journal	J. Immunol
Journal Reference	v163 i7 p3819 (1999)
Journal Link	http://www.jimmunol.org/cgi/content/full/163/7/3819
Source	Curated
CellType	t cell


MedLine Reference	10477583:1266
Journal	J. Immunol
Journal Reference	v163 i6 p3160 (1999)
Journal Link	http://www.jimmunol.org/cgi/content/full/163/6/3160
Organism	mouse
Source	Curated
CellType	b cell


Journal	J. Cell Biol
Journal Reference	v157 i3 p346 (2002)
Journal Link	http://www.jcb.org/cgi/content/full/157/3/346
Source	Curated


MedLine Reference	11457834:1190
Journal	J. Biol. Chem
Journal Reference	v276 i37 p34617 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/37/34617
Source	Curated


MedLine Reference	10801808:1277
Journal	J. Biol. Chem
Journal Reference	v275 i31 p23559 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/31/23559
Organism	rat
Source	Curated


MedLine Reference	9705357:1228
Journal	J. Biol. Chem
Journal Reference	v273 i34 p22120 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/34/22120
Organism	rat
Source	Curated


MedLine Reference	9235901:1125
Journal	J. Biol. Chem
Journal Reference	v272 i31 p19125 (1997)
Journal Link	http://www.jbc.org/cgi/content/full/272/31/19125
Organism	rat
Source	Curated
CellLineName	HEK 293


MedLine Reference	9030581:1202
Journal	J. Biol. Chem
Journal Reference	v272 i8 p5141 (1997)
Journal Link	http://www.jbc.org/cgi/content/full/272/8/5141
Source	Curated
CellLineName	IS1


MedLine Reference	7852306:1190
Journal	J. Biol. Chem
Journal Reference	v270 i6 p2460 (1995)
Journal Link	http://www.jbc.org/cgi/content/full/270/6/2460
Organism	frog
Source	Curated


MedLine Reference	12473665:1196
Journal	J. Biol. Chem
Journal Reference	v278 i7 p4778 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/7/4778
Organism	rat
Source	Curated


MedLine Reference	11533045:1016
Journal	J. Biol. Chem
Journal Reference	v276 i44 p40968 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/44/40968
Source	Curated
CellLineName	HepG 2


MedLine Reference	11278385:1168
Journal	J. Biol. Chem
Journal Reference	v276 i16 p13186 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/16/13186
Source	Curated
CellType	megakaryocyte
CellLineName	K 562


MedLine Reference	10666084:1116
Journal	Heart Circul
Journal Reference	v278 i2 pH521 (2000)
Journal Link	http://ajpheart.physiology.org/cgi/content/full/278/2/H521
Organism	rat
Source	Curated


Journal	J. Cell Biol
Journal Reference	v157 i3 p346 (2002)
Journal Link	http://www.jcb.org/cgi/content/full/157/3/346
Source	Curated


MedLine Reference	9111071:1187
Journal	J. Biol. Chem
Journal Reference	v272 i17 p11557 (1997)
Journal Link	http://www.jbc.org/cgi/content/full/272/17/11557
Organism	mouse
Source	Curated


MedLine Reference	8617731:1152
Journal	J. Biol. Chem
Journal Reference	v271 i9 p4671 (1996)
Journal Link	http://www.jbc.org/cgi/content/full/271/9/4671
Organ	brain
Organism	rat
Source	Curated


MedLine Reference	11278444:1256
Journal	J. Biol. Chem
Journal Reference	v276 i24 p21521 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/24/21521
Organism	rat
Source	Curated


MedLine Reference	9606192:1230
Journal	EMBO
Journal Reference	v17 i11 p3101 (1998)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/17/11/3101
Source	Curated
CellLineName	JURKAT


Journal	Cell
Journal Reference	v88 i4 p521 (1997)
Journal Link	http://www.cell.com/cgi/content/full/88/4/521
Source	Curated
CellLineName	PY


MedLine Reference	12839928:1267
Journal	Cancer Res
Journal Reference	v63 i13 p3473 (2003)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/63/13/3473
Source	Curated


MedLine Reference	9484987:1013
Tissue	endothelial
Journal	ATVB
Journal Reference	v18 i2 p227 (1998)
Journal Link	http://atvb.ahajournals.org/cgi/content/full/18/2/227
Organ	aorta
Organism	bovine
Source	Curated


MedLine Reference	12600818:1195
Journal	AJRCMB
Journal Reference	v28 i6 p762 (2003)
Journal Link	http://ajrcmb.atsjournals.org/cgi/content/full/28/6/762
Organ	lung
Source	Curated


MedLine Reference	11287623:1128
Journal	Mol. Cell. Biol
Journal Reference	v21 i9 p3192 (2001)
Journal Link	http://mcb.asm.org/cgi/content/full/21/9/3192
Organism	mouse
Source	Curated
CellLineName	NIH 3T3


MedLine Reference	12481409:1142
Journal	Mol. Cancer Ther
Journal Reference	v1 i11 p885 (2002)
Journal Link	http://mct.aacrjournals.org/cgi/content/full/1/11/885
Organism	rat
Source	Curated
CellType	fibroblast
CellLineName	Rat1


MedLine Reference	10982386:1121
Journal	Mol. Biol. Cell
Journal Reference	v11 i9 p2863 (2000)
Journal Link	http://www.molbiolcell.org/cgi/content/full/11/9/2863
Organism	mouse
Source	Curated


MedLine Reference	10359597:1189
Journal	Mol. Biol. Cell
Journal Reference	v10 i6 p1799 (1999)
Journal Link	http://www.molbiolcell.org/cgi/content/full/10/6/1799
Source	Curated


MedLine Reference	11598192:2
Source	Curated
CellLineName	JURKAT


MedLine Reference	9495809:1229
Journal	Mol. Pharm
Journal Reference	v53 i3 p438 (1998)
Journal Link	http://molpharm.aspetjournals.org/cgi/content/full/53/3/438
Organism	rat
Source	Curated


MedLine Reference	14560030:1149
Journal	Mol. Cell. Biol
Journal Reference	v23 i21 p7875 (2003)
Journal Link	http://mcb.asm.org/cgi/content/full/23/21/7875
Source	Curated


MedLine Reference	12134066:1214
Journal	Mol. Biol. Cell
Journal Reference	v13 i7 p2256 (2002)
Journal Link	http://www.molbiolcell.org/cgi/content/full/13/7/2256
Source	Curated


MedLine Reference	9584148:1174
Journal	J. Exp. Med
Journal Reference	v187 i10 p1699 (1998)
Journal Link	http://www.jem.org/cgi/content/full/187/10/1699
Organism	mouse
Source	Curated


Journal	J. Exp. Med
Journal Reference	v192 i2 p171 (2000)
Journal Link	http://www.jem.org/cgi/content/full/192/2/171
Source	Curated
CellType	pre B


MedLine Reference	10899904:1274
Journal	J. Exp. Med
Journal Reference	v192 i2 p171 (2000)
Journal Link	http://www.jem.org/cgi/content/full/192/2/171
Organism	mouse
Source	Curated
CellType	pre B


MedLine Reference	2602125096
Sentence	Both H-Ras(G12V) and Raf-BXB, but not Cdc42(Q61L), suppressed integrin activation and activated ERK2.
Journal	Cell
Journal Reference	v88 i4 p521 (1997)
Journal Link	http://www.cell.com/cgi/content/full/88/4/521
Source	Curated
CellLineName	PY