Protein : MEF2A
Owner Public
URN urn:agi-llid:4205
Hugo ID 6993
Connectivity 476
Name MEF2A
Description myocyte enhancer factor 2A
Notes The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM]
MGI ID 99532
Cell Localization Nucleus
Pathway Jnk-mapk
p38 MAPK
Control of skeletal myogenesis
p38 Signaling
MAPK signaling
EGFR/ERBB3 -> MEF2A signaling pathway
TGFBR -> MEF2A signaling pathway
Group Transcription factors
transcription
positive regulation of transcription
regulation of transcription, DNA-dependent
transcription from RNA polymerase II promoter
muscle development
nucleus
protein binding
DNA binding
sequence-specific DNA binding
transcription factor activity
transcription coactivator activity
transcriptional activator activity
GenBank ID NC_000015
NM_005587
NP_005578
NT_035325
NW_925940
AC_000058
AC022692
U49020
AAB17195
AAB17196
AB208985
BAD92222
AL831995
BC013437
AAH13437
BC053871
AAH53871
X63381
CAA44979
X68503
CAA48516
X68505
CAA48517
Y16312
CAA76175
Q02078
Q59GX4
Q7Z6C9
NC_000073
NM_001033713
NP_001028885
NT_039428
NW_000327
NW_001030863
XM_976104
XP_981198
XM_976072
XP_981166
XM_976137
XP_981231
XM_976208
XP_981302
XM_975960
XP_981054
XM_975999
XP_981093
XM_976169
XP_981263
XM_976032
XP_981126
XM_975927
XP_981021
AC_000029
AC120123
AC158751
AK040227
AK041136
AK052385
AK132678
BAE21297
AK136368
AK153751
AV255689
BC019116
BC061128
AAH61128
BC096598
AAH96598
BG072973
BG083417
U30823
AAA74030
U94423
Q4VA09
Q60929
Source Curated
LocusLink ID 4205
17258
Organism Homo sapiens
Mus musculus
OMIM ID 600660
608320
Alias ADCAD1
RSRFC4
RSRFC9
MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)
A430079H05Rik
myocyte enhancer factor 2A
GO ID 0043565
0003713
0003700
0007517
0006355
0006350
0006366
0005634
0003677
0005515
0016563
0045941
Swiss-Prot Accession Q02078
Q59GX4
Q7Z6C9
Q4VA09
Q60929
Unigene ID Hs.268675
Mm.121691
Mm.132788
Mm.426509