Protein : HDAC5


Owner	Public
URN	urn:agi-llid:10014
Hugo ID	14068
Connectivity	152
Name	HDAC5
Description	histone deacetylase 5
Notes	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.


MGI ID	1333784


Cell Localization	Nucleus


Pathway	Control of skeletal myogenesis


Group	Deacetylases
	B cell differentiation
	regulation of progression through cell cycle
	chromatin modification
	chromatin silencing
	chromatin remodeling
	transcription
	negative regulation of transcription, DNA-dependent
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	heart development
	negative regulation of striated muscle development
	inflammatory response
	cytoplasm
	nucleus
	nuclear body
	histone deacetylase complex
	protein binding
	transcription factor binding
	transcription corepressor activity
	hydrolase activity
	histone deacetylase activity
	transcriptional repressor activity
	specific transcriptional repressor activity


Source	Curated


LocusLink ID	10014
	15184


Organism	Homo sapiens
	Mus musculus


OMIM ID	605315


Unigene ID	Hs.438782
	Mm.22665