Protein : IGF1R


Owner	Public
URN	urn:agi-llid:3480
Hugo ID	5465
Connectivity	1022
Name	IGF1R
Description	insulin-like growth factor 1 receptor
Notes	receptor for Igf-1; involved in induction of cell cycle progression and survival in many cell types [RGD]


RGD ID	2869


MGI ID	96433


Cell Localization	Plasma membrane


Pathway	Control of skeletal myogenesis
	Antiapoptotic Pathways From IGF-1R
	IGF1R -> CEBPA signaling pathway
	IGF1R -> ELK1-SRF signaling pathway
	IGF1R -> ELK4-SRF signaling pathway
	IGF1R -> FOXO1A signaling pathway
	IGF1R -> HIF1A signaling pathway
	IGF1R -> MYC signaling pathway
	IGF1R -> SREBF1 signaling pathway
	IGF1R -> STAT1 signaling pathway
	IGF1R -> STAT3 signaling pathway
	IGF1R -> STAT5A signaling pathway


Group	Kinases
	Receptors
	signal transduction
	transmembrane receptor protein tyrosine kinase signaling pathway
	insulin receptor signaling pathway
	insulin-like growth factor receptor signaling pathway
	neurite development
	regulation of progression through cell cycle
	anti-apoptosis
	positive regulation of cell proliferation
	protein amino acid phosphorylation
	protein amino acid autophosphorylation
	organ morphogenesis
	brain development
	male sex determination
	protein tetramerization
	membrane
	integral to membrane
	integral to plasma membrane
	extracellular space
	nucleotide binding
	protein binding
	ATP binding
	insulin receptor substrate binding
	phosphoinositide 3-kinase binding
	insulin-like growth factor binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity
	transmembrane receptor protein tyrosine kinase activity
	epidermal growth factor receptor activity
	insulin-like growth factor receptor activity
	receptor activity


Source	Curated


OMIM ID	147370


Alias	CD221
	IGFIR
	JTK13
	MGC142170
	MGC142172
	insulin-like growth factor 1 receptor
	clone 1900 unknown protein
	hyft
	IGF-1R
	D930020L01
	A330103N21Rik
	insulin-like growth factor I receptor
	line 186
	IGFIRC