Protein : IGF1


Owner	Public
URN	urn:agi-llid:3479
Hugo ID	5464
Connectivity	3174
Name	IGF1
Description	insulin-like growth factor 1
Notes	growth factor; plays a major role in mammalian growth [RGD]


RGD ID	2868


MGI ID	96432


Cell Localization	Extracellular


Pathway	Control of skeletal myogenesis
	IGF1R -> CEBPA signaling pathway
	IGF1R -> ELK1-SRF signaling pathway
	IGF1R -> ELK4-SRF signaling pathway
	IGF1R -> FOXO1A signaling pathway
	IGF1R -> HIF1A signaling pathway
	IGF1R -> MYC signaling pathway
	IGF1R -> SREBF1 signaling pathway
	IGF1R -> STAT1 signaling pathway
	IGF1R -> STAT3 signaling pathway
	IGF1R -> STAT5A signaling pathway


Group	Ligands
	physiological process
	signal transduction
	insulin-like growth factor receptor signaling pathway
	Ras protein signal transduction
	cell development
	glial cell differentiation
	cell motility
	anti-apoptosis
	regulation of cell proliferation
	positive regulation of cell proliferation
	regulation of protein biosynthesis
	DNA replication
	glycolate metabolism
	organ morphogenesis
	muscle development
	skeletal development
	nervous system development
	sensory perception of sound
	extracellular region
	extracellular space
	interstitial matrix
	protein binding
	steroid binding
	growth factor activity
	hormone activity
	insulin-like growth factor receptor binding
	prothoracicotrophic hormone activity


Source	Curated


OMIM ID	147440
	608747


Alias	IGFI
	insulin-like growth factor 1 (somatomedin C)
	somatomedin C
	Igf-1
	Igf-I
	C730016P09Rik
	insulin-like growth factor 1
	Insulin-like growth factor I