ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:8536:out-urn:agi-llid:4205::unknown
Entities CAMK1 ---> MEF2A
References 4
Connectivity 2
Effect unknown
MedLine Reference 12619878:2
Sentence MEF2 is held in an inactive form by the class II histone deacetylases (HDAC) until phosphorylated by either CaM kinase I or IV.
Organism rat
Tissue muscle
Organ heart
Source Curated
CellType myocyte
MedLine Reference 12896970:1327
Sentence Overexpression of active CaMK I or IV derepresses MEF2 activity in muscle by phosphorylating HDACs and promoting their nuclear export ( 18 , 19 ).
Journal J. Biol. Chem
Journal Reference v278 i42 p41472 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/42/41472
Organism rat
Tissue muscle
Source Curated
MedLine Reference 11350961:1050
Sentence In skeletal muscle CaM kinase I and IV have been implicated in mediating calcium-dependent activation of MEF2 ( 31 , 32 ) and the expression of muscle-specific genes.
Journal J. Biol. Chem
Journal Reference v276 i28 p26057 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/28/26057
Organism rat
Tissue skeletal muscle
Source Curated
MedLine Reference 10737771:1117
Sentence Together, MKK6 and CaMKI synergistically activated MEF2-dependent transcription greater than 100-fold and potently interfered with the inhibitory effect of HDAC on MEF2 activity.
Journal PNAS
Journal Reference v97 i8 p4070 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/8/4070
CellLineName B10
Organism mouse
Source Curated