Regulation :

Effect negative
Owner Public
URN urn:agi-Regulation:inout-urn:agi-cas:59865-13-3:out-urn:agi-go:0005955::negative
Entities cyclosporine ---| calcineurin
References 105
Connectivity 2
MedLine Reference 11997253:1018
Sentence Cyclosporin (CsA, 25 mg ???· kg-1 ???· day-1) was administered to block calcineurin activity.
Journal Cell Phys
Journal Reference v282 i6 pC1387 (2002)
Journal Link http://ajpcell.physiology.org/cgi/content/full/282/6/C1387
Organ tibia
Organism rat
Source Curated
MedLine Reference 9606192:1030
Sentence The immunosuppressant cyclosporin A (CsA), a calcineurin antagonist, blocks NF-ATc activation and nuclear entry (Crabtree and Clipstone, 1994 ; Rao, 1994 ).
Journal EMBO
Journal Reference v17 i11 p3101 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/11/3101
Source Curated
MedLine Reference 10030847:1286
Sentence Whereas CSA blocks cytokine gene transcription by inhibiting the Ca2+-calmodulin-dependent phosphatase calcineurin ( 41 ), dinactin had no effect on transcriptional activation nor on steady-state mRNA levels of the cytokine genes examined.
Tissue blood
Journal AJRCMB
Journal Reference v20 i3 p481 (1999)
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/20/3/481
Organism mouse
Source Curated
CellType t cell
CellLineName Mab
MedLine Reference 10899116:1020
Sentence The immunosuppressive drugs cyclosporin A (CsA) and FK506 inhibit calcineurin in association with highly conserved binding proteins, cyclophilin A and FKBP12, which are conserved from yeast to humans ( Liu et al ., 1991 ; Foor et al ., 1992 ; Breuder et al ., 1994 ; Odom et al ., 1997 ; Cruz et al ., 1999 ).
Journal EMBO
Journal Reference v19 i14 p3618 (2000)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/19/14/3618
Organism C-elegans
Source Curated
MedLine Reference 10973957:1159
Journal J. Biol. Chem
Journal Reference v275 i49 p38620 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/49/38620
Source Curated
CellType neural
MedLine Reference 10931822:1112
Journal J. Biol. Chem
Journal Reference v275 i44 p34017 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/44/34017
Organism rat
Source Curated
CellLineName HEK 293
MedLine Reference 10799529:1303
Journal J. Biol. Chem
Journal Reference v275 i19 p14466 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/19/14466
Organ heart
Organism rat
Source Curated
MedLine Reference 10788473:1307
Journal J. Biol. Chem
Journal Reference v275 i18 p13571 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/18/13571
Organ heart
Organism mouse
Source Curated
MedLine Reference 10777482:1024
Tissue muscle
Journal J. Biol. Chem
Journal Reference v275 i26 p19653 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/26/19653
Organism rat
Source Curated
MedLine Reference 10636885:1127
Journal J. Biol. Chem
Journal Reference v275 i3 p1855 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/3/1855
Organism rat
Source Curated
MedLine Reference 10636861:1197
Journal J. Biol. Chem
Journal Reference v275 i3 p1673 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/3/1673
Source Curated
MedLine Reference 10085155:1011
Journal J. Biol. Chem
Journal Reference v274 i13 p9061 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/13/9061
Organ hippocampal
Organism rat
Source Curated
CellType neural
MedLine Reference 10026208:1173
Tissue islet
Journal J. Biol. Chem
Journal Reference v274 i9 p5851 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/9/5851
Organ pancreas
Source Curated
MedLine Reference 11511537:1009
Journal Genes & Dev
Journal Reference v15 i16 p2054 (2001)
Journal Link http://www.genesdev.org/cgi/content/full/15/16/2054
Organ heart
Organism mouse
Source Curated
MedLine Reference 11316738:1215
Journal Endocrinology
Journal Reference v142 i5 p1752 (2001)
Journal Link http://endo.endojournals.org/cgi/content/full/142/5/1752
Organism rat
Source Curated
CellType neural
MedLine Reference 9367995:1031
Journal J. Biol. Chem
Journal Reference v272 i47 p29415 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/47/29415
Organism mouse
Source Curated
MedLine Reference 9202010:1115
Journal J. Biol. Chem
Journal Reference v272 i27 p16978 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/27/16978
Organism rat
Source Curated
MedLine Reference 8663324:1298
Tissue glia
Journal J. Biol. Chem
Journal Reference v271 i28 p16888 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/28/16888
Organism rat
Source Curated
CellType neural
MedLine Reference 8662792:1020
Journal J. Biol. Chem
Journal Reference v271 i23 p13362 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/23/13362
Source Curated
CellType t cell
MedLine Reference 8576121:1189
Journal J. Biol. Chem
Journal Reference v271 i3 p1336 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/3/1336
Organism dog
Source Curated
CellType neural
MedLine Reference 7814389:1014
Journal J. Biol. Chem
Journal Reference v270 i1 p29 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/1/29
Organism frog
Source Curated
MedLine Reference 7559604:1025
Journal J. Biol. Chem
Journal Reference v270 i42 p24831 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/42/24831
Organism yeast
Source Curated
CellType neural
MedLine Reference 12783880:1017
Journal J. Biol. Chem
Journal Reference v278 i35 p32517 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/35/32517
Organ pancreas
Organism rat
Source Curated
MedLine Reference 12522136:1251
Journal J. Biol. Chem
Journal Reference v278 i15 p13143 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/15/13143
Organ heart
Organism rat
Source Curated
MedLine Reference 12393911:1093
Journal J. Biol. Chem
Journal Reference v277 i51 p49585 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/51/49585
Organism mouse
Source Curated
CellType b cell
MedLine Reference 12215435:1037
Journal J. Biol. Chem
Journal Reference v277 i46 p43599 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/46/43599
Organism rat
Source Curated
CellLineName HIT
MedLine Reference 12145283:1234
Tissue smooth muscle
Journal J. Biol. Chem
Journal Reference v277 i40 p37756 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/40/37756
Organ artery
Organism mouse
Source Curated
MedLine Reference 12050171:1012
Tissue endothelial
Journal J. Biol. Chem
Journal Reference v277 i33 p29669 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/33/29669
Organism bovine
Source Curated
MedLine Reference 11509557:1022
Journal J. Biol. Chem
Journal Reference v276 i45 p42492 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/45/42492
Organism rat
Source Curated
MedLine Reference 11435416:1016
Journal J. Biol. Chem
Journal Reference v276 i37 p34983 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/37/34983
Organ heart
Organism rat
Source Curated
CellType myocyte
MedLine Reference 11292823:1016
Journal J. Biol. Chem
Journal Reference v276 i25 p22397 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/25/22397
Organism mouse
Source Curated
Source Curated
CellType t cell
MedLine Reference 7687744:0
Source Curated
CellType t cell
MedLine Reference 10773018:1196
Journal JPET
Journal Reference v293 i2 p480 (2000)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/293/2/480
Organism rat
Source Curated
CellType neural
MedLine Reference 10648711:1145
Journal J. Neurosci
Journal Reference v20 i3 p1056 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/3/1056
Organism plant
Source Curated
CellLineName HEK 293
MedLine Reference 10559378:1119
Journal J. Neurosci
Journal Reference v19 i22 p9687 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/22/9687
Organism mouse
Source Curated
MedLine Reference 10436057:1014
Journal J. Neurosci
Journal Reference v19 i16 p7025 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/16/7025
Organism rat
Source Curated
MedLine Reference 9780210:1241
Journal J. Immunol
Journal Reference v161 i8 p4332 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/161/8/4332
Source Curated
CellType lymphocyte
MedLine Reference 9551973:1035
Journal J. Immunol
Journal Reference v160 i1 p209 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/160/1/209
Source Curated
CellType lymphocyte
MedLine Reference 12193749:1242
Journal J. Immunol
Journal Reference v169 i5 p2747 (2002)
Journal Link http://www.jimmunol.org/cgi/content/full/169/5/2747
Source Curated
CellType t cell
MedLine Reference 11207318:1046
Tissue calvaria
Journal J. Immunol
Journal Reference v166 i5 p3574 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/5/3574
Organism drosophila
Source Curated
MedLine Reference 10586059:1019
Journal J. Immunol
Journal Reference v163 i12 p6640 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/12/6640
Source Curated
CellType t cell
CellLineName JURKAT
MedLine Reference 9034151:1147
Journal J. Exp. Med
Journal Reference v185 i4 p731 (1997)
Journal Link http://www.jem.org/cgi/content/full/185/4/731
Organism mouse
Source Curated
CellType t cell
Journal J. Exp. Med
Journal Reference v197 i12 p1689 (2003)
Journal Link http://www.jem.org/cgi/content/full/197/12/1689
Source Curated
CellType t cell
MedLine Reference 11535618:1029
Journal J. Cell Biol
Journal Reference v154 i5 p951 (2001)
Journal Link http://www.jcb.org/cgi/content/full/154/5/951
Organism yeast
Source Curated
CellType t cell
MedLine Reference 9774393:1252
Journal J. Biol. Chem
Journal Reference v273 i43 p27831 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/43/27831
Organism C-elegans
Source Curated
MedLine Reference 9405450:1146
Journal J. Biol. Chem
Journal Reference v272 i51 p32411 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/51/32411
Organism rat
Source Curated
CellType t cell
MedLine Reference 11061569:0
Source Curated
CellType t cell
MedLine Reference 9510372:5
Source Curated
CellType t cell
MedLine Reference 8828502:4
Organ pituitar
Source Curated
MedLine Reference 9472103:1
Source Curated
CellType granulocyte
CellLineName HL 60
MedLine Reference 10501227:3
Organism bovine
Source Curated
MedLine Reference 10901483:4
Organism rat
Source Curated
CellType cardiomyocyte
MedLine Reference 10873609:2
Organ heart
Organism rat
Source Curated
MedLine Reference 10843911:1
Organ heart
Organism rat
Source Curated
MedLine Reference 9749826:4
Organism rat
Source Curated
CellType astrocyte
MedLine Reference 8893011:1
Organism mouse
Source Curated
CellType lymphocyte
MedLine Reference 7540976:0
Organism yeast
Source Curated
MedLine Reference 7705972:2
Organism mouse
Source Curated
CellType t cell
MedLine Reference 7868886:4
Organism mouse
Source Curated
CellType b cell
MedLine Reference 7529175:0
Organism yeast
Source Curated
MedLine Reference 7522304:1
Organism yeast
Source Curated
CellType t cell
MedLine Reference 7515500:0
Organism yeast
Source Curated
CellType t cell
MedLine Reference 12619929:10
Tissue bone
Source Curated
CellType osteoclast
MedLine Reference 12475968:5
Source Curated
CellType t cell
MedLine Reference 11982754:1
Source Curated
CellType t cell
MedLine Reference 10518828:0
Source Curated
CellType t cell
MedLine Reference 14967063:5
Organ immunologic
Source Curated
CellType T-helper
MedLine Reference 14722106:3
Source Curated
CellType macrophage
CellLineName RAW264.7
MedLine Reference 15087419:6
Organ ventricle
Organism mouse
Source Curated
CellType myocyte
CellLineName MI
MedLine Reference 15044094:0
Organism mouse
Source Curated
MedLine Reference 14684598:6
Tissue skeletal
Organism mouse
Source Curated
CellType myoblast
MedLine Reference 12877795:3
Organ lung
Organism rat
Source Curated
CellType fibroblast
MedLine Reference 12690700:8
Organism mouse
Source Curated
MedLine Reference 12899339:5
Organism rat
Source Curated
CellType cardiomyocyte
MedLine Reference 11915517:1
Organ heart
Organism yeast
Source Curated
CellType t cell
MedLine Reference 11847103:0
Organism yeast
Source Curated
CellType t cell
MedLine Reference 11448138:8
Organ aorta
Organism mouse
Source Curated
MedLine Reference 11248077:1
Organ heart
Organism mouse
Source Curated
MedLine Reference 15716327:0
Source Curated
CellType t cell
MedLine Reference 15759284:8
Source Curated
CellType osteoclast
MedLine Reference 15681847:3
Tissue intima
Organism rat
Source Curated
MedLine Reference 15734836:12
Organism mouse
Source Curated
MedLine Reference 15635017:0
Organism yeast
Source Curated
MedLine Reference 9374467:1106
Journal Science
Journal Reference v278 i5343 p1638 (1997)
Journal Link http://www.sciencemag.org/cgi/content/full/278/5343/1638
Source Curated
CellLineName BHK
MedLine Reference 12091710:1025
Tissue testis
Journal PNAS
Journal Reference v99 i14 p9398 (2002)
Journal Link http://www.pnas.org/cgi/content/full/99/14/9398
Organ brain
Organism mouse
Source Curated
MedLine Reference 11904392:1139
Journal PNAS
Journal Reference v99 i7 p4586 (2002)
Journal Link http://www.pnas.org/cgi/content/full/99/7/4586
Organ heart
Organism mouse
Source Curated
MedLine Reference 11606756:1027
Journal PNAS
Journal Reference v98 i23 p13108 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/23/13108
Organism rat
Source Curated
CellType t cell
MedLine Reference 11050161:1155
Journal PNAS
Journal Reference v97 i23 p12840 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/23/12840
Organism mouse
Source Curated
MedLine Reference 10655507:1084
Journal PNAS
Journal Reference v97 i3 p1196 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/3/1196
Organism bovine
Source Curated
CellType cardiomyocyte
MedLine Reference 12163676:1033
Journal Nutrition
Journal Reference v132 i8 p2283 (1996)
Journal Link http://www.nutrition.org/cgi/content/full/132/8/2283
Organism rat
Source Curated
CellType t cell
MedLine Reference 10446906:1147
Journal Mol. Endocrin
Journal Reference v13 i8 p1318 (1999)
Journal Link http://mend.endojournals.org/cgi/content/full/13/8/1318
Organ luteal
Organism rat
Source Curated
MedLine Reference 12773574:1031
Tissue testis
Journal Mol. Cell. Biol
Journal Reference v23 i12 p4331 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/12/4331
Organ brain
Organism mouse
Source Curated
MedLine Reference 11865053:1222
Journal Mol. Cell. Biol
Journal Reference v22 i6 p1734 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/6/1734
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 10207088:1028
Journal Mol. Cell. Biol
Journal Reference v19 i5 p3645 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/5/3645
Source Curated
MedLine Reference 7474947:0
Source Curated
MedLine Reference 7536769:10
Source Curated
CellLineName JURKAT
Source Curated
CellLineName HEK 293
Source Curated
CellLineName 293
MedLine Reference 12925456:9
Organ ventricle
Organism mouse
Source Curated
MedLine Reference 12065751:0
Organism rat
Source Curated
MedLine Reference 11390462:1151
Tissue medulla
Journal J. Immunol
Journal Reference v166 i12 p7158 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/12/7158
Organ thymal
Organism rat
Source Curated
CellType t cell
MedLine Reference 9099725:1104
Journal J. Biol. Chem
Journal Reference v272 i16 p10746 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/16/10746
Source Curated
CellLineName JURKAT
MedLine Reference 9575084:1024
Journal Science
Journal Reference v280 i5362 p383 (1998)
Journal Link http://www.sciencemag.org/cgi/content/full/280/5362/383
Organ heart
Organism mouse
Source Curated
MedLine Reference 2801046885
Sentence CyPs were originally discovered because of their affinity for the potent immunosuppressive drug cyclosporine A ( Handschumacher et al., 1984 ); the CyP-cyclosporine A complex binds and inactivates the calcium-dependent phosphatase calcineurin, thus blocking signal transduction in activated T-cells ( Schreiber and Crabtree, 1992 ).
Journal Cell
Journal Reference v87 i7 p1157 (1996)
Journal Link http://www.cell.com/cgi/content/full/87/7/1157
Source Curated
CellType t cell