Regulation :

Effect negative
Owner Public
URN urn:agi-Regulation:inout-urn:agi-cas:104987-11-3:out-urn:agi-go:0005955::negative
Entities FK506 ---| calcineurin
References 116
Connectivity 2
MedLine Reference 10779414:1168
Sentence The calcineurin inhibitors CsA and FK506 are widely used to block calcineurin activation.
Journal Blood
Journal Reference v95 i9 p2733 (2000)
Journal Link http://www.bloodjournal.org/cgi/content/full/95/9/2733
Source Curated
CellType t cell
MedLine Reference 10029080:1032
Sentence The FKBP-FK506 complex inhibits calcineurin, preventing dephosphorylation, nuclear translocation of NF-ATp, and activation of interleukin 2 transcription (25 , 26 , 27) .
Journal Cancer Res
Journal Reference v59 i4 p886 (1999)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/59/4/886
Source Curated
CellType t cell
MedLine Reference 11230126:1140
Sentence Secondly, overexpression of the STE12 alpha gene stimulated haploid fruiting of wild-type MAT alpha cells, but failed to stimulate haploid fruiting in cells in which calcineurin was inhibited by FK506 or CsA (data not shown).
Journal EMBO
Journal Reference v20 i5 p1020 (2001)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/20/5/1020
Organism yeast
Source Curated
CellType Lymphocyte Subsets
MedLine Reference 11719426:1228
Sentence This conjecture is supported by previous findings that CsA and FK506, the two most commonly used inhibitors for NFAT activation, exhibit a strong antitumor promotion activity by specifically targeting and blocking the activation of a Ca 2+ -dependent phosphatase, calcineurin (10) .
Journal Cancer Res
Journal Reference v61 i22 p8051 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/22/8051
Organism mouse
Source Curated
MedLine Reference 10899116:1020
Sentence The immunosuppressive drugs cyclosporin A (CsA) and FK506 inhibit calcineurin in association with highly conserved binding proteins, cyclophilin A and FKBP12, which are conserved from yeast to humans ( Liu et al ., 1991 ; Foor et al ., 1992 ; Breuder et al ., 1994 ; Odom et al ., 1997 ; Cruz et al ., 1999 ).
Journal EMBO
Journal Reference v19 i14 p3618 (2000)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/19/14/3618
Organism C-elegans
Source Curated
MedLine Reference 15716327:0
Source Curated
CellType t cell
MedLine Reference 15649649:7
Source Curated
CellType monocyte
CellLineName JURKAT
MedLine Reference 14722106:3
Source Curated
CellType macrophage
CellLineName RAW264.7
MedLine Reference 15571979:4
Organism rat
Source Curated
CellType neural
MedLine Reference 15320493:1
Organism mouse
Source Curated
CellType neural
MedLine Reference 15044154:1
Organ pancreas
Organism rat
Source Curated
MedLine Reference 15146068:0
Organism yeast
Source Curated
MedLine Reference 12091710:1025
Tissue testis
Journal PNAS
Journal Reference v99 i14 p9398 (2002)
Journal Link http://www.pnas.org/cgi/content/full/99/14/9398
Organ brain
Organism mouse
Source Curated
MedLine Reference 11904392:1139
Journal PNAS
Journal Reference v99 i7 p4586 (2002)
Journal Link http://www.pnas.org/cgi/content/full/99/7/4586
Organ heart
Organism mouse
Source Curated
MedLine Reference 11606756:1027
Journal PNAS
Journal Reference v98 i23 p13108 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/23/13108
Organism rat
Source Curated
CellType t cell
MedLine Reference 10318964:1113
Journal PNAS
Journal Reference v96 i10 p5797 (1999)
Journal Link http://www.pnas.org/cgi/content/full/96/10/5797
Organ heart
Organism rat
Source Curated
CellType t cell
MedLine Reference 10077670:1119
Journal PNAS
Journal Reference v96 i6 p3251 (1999)
Journal Link http://www.pnas.org/cgi/content/full/96/6/3251
Organism rat
Source Curated
CellLineName PC 12
MedLine Reference 11040041:1023
Journal Mol. Pharm
Journal Reference v58 i5 p946 (2000)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/58/5/946
Organism rat
Source Curated
CellType t cell
MedLine Reference 12773574:1031
Tissue testis
Journal Mol. Cell. Biol
Journal Reference v23 i12 p4331 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/12/4331
Organ brain
Organism mouse
Source Curated
MedLine Reference 12665571:1264
Journal Mol. Cell. Biol
Journal Reference v23 i8 p2680 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/8/2680
Organ cerebellar
Organism mouse
Source Curated
CellType neural
MedLine Reference 10207088:1028
Journal Mol. Cell. Biol
Journal Reference v19 i5 p3645 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/5/3645
Source Curated
Organ brain
Source Curated
MedLine Reference 7512727:0
Organism rat
Source Curated
MedLine Reference 9774347:1031
Journal EMBO
Journal Reference v17 i20 p6039 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/20/6039
Organism mouse
Source Curated
MedLine Reference 11847103:1029
Journal EMBO
Journal Reference v21 i4 p546 (2002)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/21/4/546
Organism yeast
Source Curated
CellType t cell
MedLine Reference 10799559:1121
Journal J. Biol. Chem
Journal Reference v275 i19 p14708 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/19/14708
Organism mouse
Source Curated
MedLine Reference 10801867:1077
Journal J. Biol. Chem
Journal Reference v275 i33 p25381 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/33/25381
Organism mouse
Source Curated
MedLine Reference 10358074:1036
Journal J. Biol. Chem
Journal Reference v274 i24 p17171 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/24/17171
Source Curated
CellLineName CHO
MedLine Reference 11406593:1047
Journal EMBO
Journal Reference v20 i12 p3167 (2001)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/20/12/3167
Organism yeast
Source Curated
MedLine Reference 7631347:1125
Journal Stroke
Journal Reference v26 i8 p1415 (1995)
Journal Link http://stroke.ahajournals.org/cgi/content/full/26/8/1415
Organ brain
Organism rat
Source Curated
CellType t cell
MedLine Reference 9575084:1024
Journal Science
Journal Reference v280 i5362 p383 (1998)
Journal Link http://www.sciencemag.org/cgi/content/full/280/5362/383
Organ heart
Organism mouse
Source Curated
MedLine Reference 9211847:1089
Journal Science
Journal Reference v277 i5323 p221 (1997)
Journal Link http://www.sciencemag.org/cgi/content/full/277/5323/221
Organism mouse
Source Curated
CellType t cell
CellLineName JURKAT
MedLine Reference 12881512:1242
Journal J. Biol. Chem
Journal Reference v278 i39 p36981 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/39/36981
Organ brain
Source Curated
MedLine Reference 12783880:1017
Journal J. Biol. Chem
Journal Reference v278 i35 p32517 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/35/32517
Organ pancreas
Organism rat
Source Curated
MedLine Reference 12145283:1234
Tissue smooth muscle
Journal J. Biol. Chem
Journal Reference v277 i40 p37756 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/40/37756
Organ artery
Organism mouse
Source Curated
MedLine Reference 12110686:1312
Journal J. Biol. Chem
Journal Reference v277 i38 p35605 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/38/35605
Source Curated
CellType lymphocyte
MedLine Reference 11997392:1167
Journal J. Biol. Chem
Journal Reference v277 i28 p25640 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/28/25640
Source Curated
CellType t cell
MedLine Reference 11976320:1207
Journal J. Biol. Chem
Journal Reference v277 i27 p24169 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/27/24169
Source Curated
MedLine Reference 11790791:1263
Journal J. Biol. Chem
Journal Reference v277 i12 p10073 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/12/10073
Source Curated
CellType t cell
MedLine Reference 11323438:1262
Journal J. Biol. Chem
Journal Reference v276 i31 p29410 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/31/29410
Organism mouse
Source Curated
CellType t cell
MedLine Reference 11292823:1237
Journal J. Biol. Chem
Journal Reference v276 i25 p22397 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/25/22397
Organism mouse
Source Curated
MedLine Reference 10931822:1112
Journal J. Biol. Chem
Journal Reference v275 i44 p34017 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/44/34017
Organism rat
Source Curated
CellLineName HEK 293
MedLine Reference 10636861:1197
Journal J. Biol. Chem
Journal Reference v275 i3 p1673 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/3/1673
Source Curated
MedLine Reference 10617605:1020
Journal J. Biol. Chem
Journal Reference v275 i1 p197 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/1/197
Organism mouse
Source Curated
CellType lymphocyte
MedLine Reference 10521511:1187
Journal J. Biol. Chem
Journal Reference v274 i43 p31102 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/43/31102
Organism rat
Source Curated
CellType neural
MedLine Reference 10224109:1025
Journal J. Biol. Chem
Journal Reference v274 i19 p13443 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/19/13443
Source Curated
CellType t cell
MedLine Reference 10026208:1172
Journal J. Biol. Chem
Journal Reference v274 i9 p5851 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/9/5851
Source Curated
MedLine Reference 11171634:1167
Journal Gastr. Liver Phys
Journal Reference v280 i3 pG501.html (2001)
Journal Link http://ajpgi.physiology.org/cgi/content/full/280/3/G501.h
Source Curated
MedLine Reference 11889139:1094
Journal J. Cell Biol
Journal Reference v156 i6 p983 (2002)
Journal Link http://www.jcb.org/cgi/content/full/156/6/983
Source Curated
MedLine Reference 11535618:1029
Journal J. Cell Biol
Journal Reference v154 i5 p951 (2001)
Journal Link http://www.jcb.org/cgi/content/full/154/5/951
Organism yeast
Source Curated
CellType t cell
MedLine Reference 9867815:1152
Journal J. Biol. Chem
Journal Reference v274 i1 p93 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/1/93
Source Curated
CellType neutrophil
MedLine Reference 9792689:1271
Journal J. Biol. Chem
Journal Reference v273 i45 p29754 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/45/29754
Organism mouse
Source Curated
CellType macrophage
CellLineName J774
MedLine Reference 9660798:1229
Journal J. Biol. Chem
Journal Reference v273 i29 p18325 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/29/18325
Organism rat
Source Curated
MedLine Reference 9367995:1031
Journal J. Biol. Chem
Journal Reference v272 i47 p29415 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/47/29415
Organism mouse
Source Curated
MedLine Reference 9312132:1132
Journal J. Biol. Chem
Journal Reference v272 i40 p25190 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/40/25190
Organism mouse
Source Curated
CellType t cell
MedLine Reference 8939917:1102
Journal J. Biol. Chem
Journal Reference v271 i47 p29792 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/47/29792
Organism mouse
Source Curated
MedLine Reference 8702500:1206
Journal J. Biol. Chem
Journal Reference v271 i31 p18527 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/31/18527
Organism mouse
Source Curated
MedLine Reference 8662792:1020
Journal J. Biol. Chem
Journal Reference v271 i23 p13362 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/23/13362
Source Curated
CellType t cell
MedLine Reference 8662717:1011
Journal J. Biol. Chem
Journal Reference v271 i23 p13484 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/23/13484
Organism mouse
Source Curated
CellLineName elm-i I
MedLine Reference 8617780:1233
Tissue skeletal muscle
Journal J. Biol. Chem
Journal Reference v271 i9 p5033 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/9/5033
Organism rat
Source Curated
MedLine Reference 7642551:1011
Journal J. Biol. Chem
Journal Reference v270 i32 p18935 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/32/18935
Source Curated
MedLine Reference 7592869:1014
Journal J. Biol. Chem
Journal Reference v270 i44 p26511 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/44/26511
Organism dog
Source Curated
CellType t cell
MedLine Reference 7559604:1025
Journal J. Biol. Chem
Journal Reference v270 i42 p24831 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/42/24831
Organism yeast
Source Curated
CellType neural
MedLine Reference 7540169:1013
Journal J. Biol. Chem
Journal Reference v270 i24 p14445 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/24/14445
Source Curated
CellType t cell
MedLine Reference 1450631:5
Source Curated
CellType t cell
MedLine Reference 1373887:4
Source Curated
CellType t cell
Tissue cortex
Organ brain
Source Curated
Source Curated
CellType astrocyte
CellLineName PSI+
MedLine Reference 9918571:1041
Journal JPET
Journal Reference v288 i2 p653 (1999)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/288/2/653
Organ brain
Organism rat
Source Curated
MedLine Reference 11303055:1196
Journal JPET
Journal Reference v297 i2 p657 (2001)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/297/2/657
Organism bovine
Source Curated
MedLine Reference 11160416:1020
Journal J. Neurosci
Journal Reference v21 i4 pRC131 (2001)
Journal Link http://www.jneurosci.org/cgi/content/full/21/4/RC131
Organism rat
Source Curated
Tissue thoracic
Journal J. Neurochem
Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2001.00505.x/full/
Organ spinal cord
Source Curated
Journal J. Neurochem
Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2001.00505.x/full/
Source Curated
CellType neural
MedLine Reference 9973469:1168
Journal J. Immunol
Journal Reference v162 i4 p1988 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/162/4/1988
Source Curated
CellType t cell
MedLine Reference 9551973:1035
Journal J. Immunol
Journal Reference v160 i1 p209 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/160/1/209
Source Curated
CellType lymphocyte
MedLine Reference 12193749:1242
Journal J. Immunol
Journal Reference v169 i5 p2747 (2002)
Journal Link http://www.jimmunol.org/cgi/content/full/169/5/2747
Source Curated
CellType t cell
MedLine Reference 11509611:1309
Journal J. Immunol
Journal Reference v167 i5 p2677 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/167/5/2677
Organism mouse
Source Curated
CellType t cell
CellLineName D10
MedLine Reference 11390463:1023
Journal J. Immunol
Journal Reference v166 i12 p7165 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/12/7165
Organism mouse
Source Curated
CellType b cell
MedLine Reference 10586059:1019
Journal J. Immunol
Journal Reference v163 i12 p6640 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/12/6640
Source Curated
CellType t cell
CellLineName JURKAT
MedLine Reference 10202017:1024
Journal J. Immunol
Journal Reference v162 i8 p4755 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/162/8/4755
Organism mouse
Source Curated
MedLine Reference 8981925:0
Source Curated
CellType t cell
MedLine Reference 7687744:0
Source Curated
CellType t cell
MedLine Reference 9472103:1
Source Curated
CellType granulocyte
CellLineName HL 60
MedLine Reference 9572286:3
Organism rat
Source Curated
CellType astrocyte
MedLine Reference 9466703:5
Organism rat
Source Curated
CellType astrocyte
MedLine Reference 9396011:2
Organism rat
Source Curated
MedLine Reference 8980772:1
Organ immunologic
Organism yeast
Source Curated
CellType t cell
MedLine Reference 8893011:1
Organism mouse
Source Curated
CellType lymphocyte
MedLine Reference 8566225:4
Organism yeast
Source Curated
MedLine Reference 8582630:0
Organism yeast
Source Curated
MedLine Reference 7544441:5
Tissue dorsal root ganglion
Organism bovine
Source Curated
CellType neural
MedLine Reference 7542793:3
Organ kidney
Organism rat
Source Curated
MedLine Reference 7540976:0
Organism yeast
Source Curated
MedLine Reference 7532685:2
Organism mouse
Source Curated
CellType t cell
CellLineName DP
MedLine Reference 7515500:0
Organism yeast
Source Curated
CellType t cell
MedLine Reference 7683641:3
Organism bovine
Source Curated
MedLine Reference 11982754:1
Source Curated
CellType t cell
MedLine Reference 10518828:0
Source Curated
CellType t cell
MedLine Reference 11061569:0
Source Curated
CellType t cell
Source Curated
CellLineName GFP(+
MedLine Reference 14753416:3
Organ brain
Organism rat
Source Curated
MedLine Reference 14657369:3
Organism rat
Source Curated
CellType neural
MedLine Reference 12689815:4
Organ heart
Organism rat
Source Curated
MedLine Reference 11958839:1
Organ brain
Organism rat
Source Curated
MedLine Reference 11915517:1
Organ heart
Organism yeast
Source Curated
CellType t cell
MedLine Reference 11702083:0
Organism rat
Source Curated
MedLine Reference 11354410:2
Organism rat
Source Curated
MedLine Reference 11248077:1
Organ heart
Organism mouse
Source Curated
MedLine Reference 11007881:2
Organism rat
Source Curated
CellType neural
MedLine Reference 10655507:7
Organ heart
Organism bovine
Source Curated
CellType cardiomyocyte
MedLine Reference 9878202:5
Organism rat
Source Curated
CellType neural
MedLine Reference 9762012:3
Organ pituitar
Organism rat
Source Curated
MedLine Reference 15757646:0
Source Curated
MedLine Reference 10730553:0
Source Curated
MedLine Reference 9010851:8
Source Curated
MedLine Reference 8680047:14
Source Curated