Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:4205:inout-urn:agi-llid:2033:
Entities EP300 ---- MEF2A
References 33
MedLine Reference 12371907:5
Sentence Our findings showed that the same C-terminal portion of p300 binds the N-terminal domains of both TR and MEF2A, and our in vivo studies demonstrated that TR, MEF2A and p300 form a ternary complex.
Tissue thyroid
CellLineName U2 OS
MedLine Reference 11096067:2
Sentence Maximal expression of the promoter in cultured myocytes and in vivo correlated with binding of both MEF-2 and p300, but not GATA-4, to this AT-rich motif. p300 and MEF-2 were coprecipitated from cardiac nuclear extracts by an oligomer containing this element. p300 was found exclusively in a complex with MEF-2D at this and related sites in other cardiac-restricted promoters.
Organ heart
CellType myocyte
Organism Mus musculus
MedLine Reference 16043483:10194
Sentence On the other hand, the MADS box of MEF2 is known to bind p300 directly ( 40 ).
Journal J. Biol. Chem
Journal Reference v280 i37 p32272
Journal Link http://www.jbc.org/cgi/content/full/280/37/32272
Organism Mus musculus
MedLine Reference 10617605:10385
Journal J. Biol. Chem
Journal Reference v275 i1 p197
Journal Link http://www.jbc.org/cgi/content/full/275/1/197
Organism Mus musculus
MedLine Reference 11390982:10032
Journal PNAS
Journal Reference v98 i13 p7354
Journal Link http://www.pnas.org/cgi/content/full/98/13/7354
Organism Mus musculus
MedLine Reference 15767673:10383
Journal Mol. Cell. Biol
Journal Reference v25 i7 p2673
Journal Link http://mcb.asm.org/cgi/content/full/25/7/2673
Organism Rattus norvegicus
MedLine Reference 11096122:10138
Journal J. Biol. Chem
Journal Reference v276 i5 p2975
Journal Link http://www.jbc.org/cgi/content/full/276/5/2975
MedLine Reference 15743823:10329
Journal Mol. Cell. Biol
Journal Reference v25 i6 p2273
Journal Link http://mcb.asm.org/cgi/content/full/25/6/2273
MedLine Reference 12761226:10046
Journal J. Biol. Chem
Journal Reference v278 i31 p28930
Journal Link http://www.jbc.org/cgi/content/full/278/31/28930
Organism Mus musculus
MedLine Reference 11994297:10265
Journal J. Biol. Chem
Journal Reference v277 i27 p24390
Journal Link http://www.jbc.org/cgi/content/full/277/27/24390
Organism Mus musculus
MedLine Reference 10887150:10568
Journal Genes & Dev
Journal Reference v14 i13 p1553
Journal Link http://www.genesdev.org/cgi/content/full/14/13/1553
MedLine Reference 15024082:10359
Journal Mol. Cell. Biol
Journal Reference v24 i7 p2944
Journal Link http://mcb.asm.org/cgi/content/full/24/7/2944
Organism Mus musculus
MedLine Reference 16260608:10330
Journal Mol. Cell. Biol
Journal Reference v25 i22 p9936
Journal Link http://mcb.asm.org/cgi/content/full/25/22/9936
Organism Mus musculus
MedLine Reference 15831463:10123
Journal Mol. Cell. Biol
Journal Reference v25 i9 p3575
Journal Link http://mcb.asm.org/cgi/content/full/25/9/3575
MedLine Reference 10973962:10290
Journal J. Biol. Chem
Journal Reference v275 i47 p36750
Journal Link http://www.jbc.org/cgi/content/full/275/47/36750
Organism Mus musculus
MedLine Reference 9242676:10150
Journal J. Biol. Chem
Journal Reference v272 i32 p20049
Journal Link http://www.jbc.org/cgi/content/full/272/32/20049
Organism Mus musculus
MedLine Reference 15930130:10228
Journal Mol. Biol. Cell
Journal Reference v16 i8 p3632
Journal Link http://www.molbiolcell.org/cgi/content/full/16/8/3632
Organism Mus musculus
MedLine Reference 12130539:10030
Journal Genes & Dev
Journal Reference v16 i14 p1792
Journal Link http://www.genesdev.org/cgi/content/full/16/14/1792
Organism Mus musculus
MedLine Reference 11096067:1271
Sentence Cardiac MEF-2 and p300 interact in a DNA-dependent manner.
Organ heart
Journal J. Biol. Chem
Journal Reference v276 i10 p7575 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/10/7575
Organism rat
Source Curated
MedLine Reference 10944115:1165
Sentence It is known that MEF2 binds to the coactivator p300 ( Sartorelli et al ., 1997 ).
Journal EMBO
Journal Reference v19 i16 p4323 (2000)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/19/16/4323
Source Curated
MedLine Reference 10567378:1239
Sentence In addition, it has been reported that MEF-2 proteins, which play important roles in cardiac and skeletal muscle development, also interact with p300 ( 20 ).
Organ heart
Tissue muscle
Journal J. Biol. Chem
Journal Reference v274 i48 p34096 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/48/34096
Organism mouse
Source Curated
MedLine Reference 10887150:1568
Sentence Similar findings were reported by Eckner et al. (1996) , who noted that the interaction involved the bHLH domain of myo-D and suggested that p300 could bind to MEF-2 as well.
Tissue muscle
Journal Genes & Dev
Journal Reference v14 i13 p1553 (2000)
Journal Link http://www.genesdev.org/cgi/content/full/14/13/1553
Source Curated
MedLine Reference 11994297:1265
Sentence Interestingly, MEF2 also interacts with p300, collectively suggesting a model whereby each of these interacting factors is part of a larger complex nucleated through p300 ( 55 , 56 ).
CellType cardiomyocyte
Journal J. Biol. Chem
Journal Reference v277 i27 p24390 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/27/24390
Organism rat
Source Curated
MedLine Reference 12371907
Source Curated
MedLine Reference 10737771:1158
CellType cardiomyocyte
Journal PNAS
Journal Reference v97 i8 p4070 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/8/4070
Organism mouse
Source Curated
MedLine Reference 11390982:1032
Tissue skeletal muscle
Journal PNAS
Journal Reference v98 i13 p7354 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/13/7354
Organism mouse
Source Curated
MedLine Reference 10825153:1174
Organ thymal
Tissue muscle
Journal J. Biol. Chem
Journal Reference v275 i29 p22563 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/29/22563
Source Curated
MedLine Reference 9242676:1150
Tissue skeletal
CellType myocyte
Journal J. Biol. Chem
Journal Reference v272 i32 p20049 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/32/20049
Source Curated
MedLine Reference 12761226:1046
Organ heart
Journal J. Biol. Chem
Journal Reference v278 i31 p28930 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/31/28930
Organism rat
Source Curated
MedLine Reference 11096122:1138
CellType neural
Journal J. Biol. Chem
Journal Reference v276 i5 p2975 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/5/2975
Source Curated
MedLine Reference 10973962:1290
Journal J. Biol. Chem
Journal Reference v275 i47 p36750 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/47/36750
Organism mouse
Source Curated
MedLine Reference 10617605:1385
Journal J. Biol. Chem
Journal Reference v275 i1 p197 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/1/197
Organism mouse
Source Curated
MedLine Reference 12130539:1030
Tissue muscle
Journal Genes & Dev
Journal Reference v16 i14 p1792 (2002)
Journal Link http://www.genesdev.org/cgi/content/full/16/14/1792
Organism mouse
Source Curated