Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:4205:inout-urn:agi-llid:10014:
Entities HDAC5 ---- MEF2A
References 35
MedLine Reference 11504882:0
Sentence The class II histone deacetylases HDAC4 and HDAC5 interact specifically with the myogenic MEF2 transcription factor and repress its activity.
Organism Mus musculus
MedLine Reference 10748098:5
Sentence We then mapped protein domains involved in the HDAC5-MEF2A interaction and showed that MADS box/MEF2-domain region of MEF2A interacts specifically with a limited region in the N-terminal part of HDAC5 which also possesses a distinct repressor domain.
MedLine Reference 10737771:10082
Sentence Interaction of MEF2 with HDAC4 and -5.
Journal PNAS
Journal Reference v97 i8 p4070
Journal Link http://www.pnas.org/cgi/content/full/97/8/4070
Organism Mus musculus
MedLine Reference 11279209:10086
Journal J. Biol. Chem
Journal Reference v276 i20 p17007
Journal Link http://www.jbc.org/cgi/content/full/276/20/17007
Organism Mus musculus
MedLine Reference 10860984:10039
Journal PNAS
Journal Reference v97 i13 p7202
Journal Link http://www.pnas.org/cgi/content/full/97/13/7202
MedLine Reference 11096122:10143
Journal J. Biol. Chem
Journal Reference v276 i5 p2975
Journal Link http://www.jbc.org/cgi/content/full/276/5/2975
MedLine Reference 12040025:10160
Journal Mol. Endocrin
Journal Reference v16 i6 p1407
Journal Link http://mend.endojournals.org/cgi/content/full/16/6/1407
Organism Mus musculus
MedLine Reference 11022042:10070
Journal J. Biol. Chem
Journal Reference v276 i1 p35
Journal Link http://www.jbc.org/cgi/content/full/276/1/35
Organism Mus musculus
MedLine Reference 11328858:10268
Journal Mol. Endocrin
Journal Reference v15 i5 p783
Journal Link http://mend.endojournals.org/cgi/content/full/15/5/783
Organism Mus musculus
MedLine Reference 12626519:10052
Journal J. Biol. Chem
Journal Reference v278 i20 p17625
Journal Link http://www.jbc.org/cgi/content/full/278/20/17625
MedLine Reference 11316766:10149
Journal Endocrinology
Journal Reference v142 i5 p1999
Journal Link http://endo.endojournals.org/cgi/content/full/142/5/1999
Organism Mus musculus
MedLine Reference 10958686:10028
Journal Mol. Cell. Biol
Journal Reference v20 i18 p6904
Journal Link http://mcb.asm.org/cgi/content/full/20/18/6904
Organism Mus musculus
MedLine Reference 10825153:10148
Journal J. Biol. Chem
Journal Reference v275 i29 p22563
Journal Link http://www.jbc.org/cgi/content/full/275/29/22563
MedLine Reference 15111488:10089
Journal Diabetes
Journal Reference v53 i5 p1208
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/53/5/1208
Organism Mus musculus
MedLine Reference 12578979:10189
Journal PNAS
Journal Reference v100 i4 p1711
Journal Link http://www.pnas.org/cgi/content/full/100/4/1711
Organism Mus musculus
MedLine Reference 11470791:10027
Journal J. Biol. Chem
Journal Reference v276 i37 p35042
Journal Link http://www.jbc.org/cgi/content/full/276/37/35042
MedLine Reference 106100710:11231
Journal EMBO
Journal Reference v24 i14 p7600729
Journal Link http://www.nature.com/emboj/journal/v24/n14/full/7600729a.html
MedLine Reference 106100671:11211
Journal EMBO
Journal Reference v24 i12 p7600685
Journal Link http://www.nature.com/emboj/journal/v24/n12/full/7600685a.html
MedLine Reference 11567998:10171
Journal Blood
Journal Reference v98 i7 p2116
Journal Link http://www.bloodjournal.org/cgi/content/full/98/7/2116
MedLine Reference 11433030:3
Sentence MEF2 proteins are activated by several kinases, including Erk5 and calcium/calmodulin-dependent kinase, and interact with repressors, including histone deacetylases 4 and 5 (HDAC4 and HDAC5) and Cabin1.
Source Curated
MedLine Reference 11470791:1027
Sentence Indeed both HDAC4 and HDAC5 interact with MEF-2 .
Tissue muscle
CellType myocyte
Journal J. Biol. Chem
Journal Reference v276 i37 p35042 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/37/35042
Source Curated
MedLine Reference 10825153:1149
Sentence Like Cabin1, HDAC4, HDAC5, and MITR were shown to bind to MEF2 and inhibit its transcriptional activity.
Journal J. Biol. Chem
Journal Reference v275 i29 p22563 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/29/22563
Source Curated
MedLine Reference 10748098:1198
Sentence Indeed, the N-terminal region of HDAC5 was found to interact with MEF2A and repress its transcriptional activity.
Journal J. Biol. Chem
Journal Reference v275 i20 p15594 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/20/15594
Organism yeast
Source Curated
MedLine Reference 12019172:1327
Sentence It has been found recently that HDAC5 regulates muscle differentiation by binding to MEF2 via its NH 2 -terminal domain and repressing expression of MEF2-dependent genes (45 , 46) .
Source Curated
MedLine Reference 11022042:1070
Sentence In previous studies, we ( 13 ) and others ( 7 , 8 , 11 , 14 ) showed that association of HDACs 4, 5, and 7 with MEF2 is mediated by a conserved 18-amino acid motif near their amino-termini.
Journal J. Biol. Chem
Journal Reference v276 i1 p35 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/1/35
Organism mouse
Source Curated
MedLine Reference 11279209:1084
Sentence RESULTS AND DISCUSSION TOP ABSTRACT INTRODUCTION EXPERIMENTAL PROCEDURES RESULTS AND DISCUSSION REFERENCES HDAC7 Represses MEF2-mediated Transactivation: MyoD and Myogenin Activity Is Refractory to Class-II HDAC-mediated Inhibition-- The class-II HDAC4 and -5 interact with MEF2 and suppress its ability to activate transcription and cell specific differentiation ( 26 , 27 , 29 , 31 ).
Journal J. Biol. Chem
Journal Reference v276 i20 p17007 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/20/17007
Organism mouse
Source Curated
MedLine Reference 10748098
Source Curated
MedLine Reference 12578979:1164
Source Curated
MedLine Reference 11081517:1
Source Curated
MedLine Reference 10737771:1097
Journal PNAS
Journal Reference v97 i8 p4070 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/8/4070
Organism mouse
Source Curated
CellLineName 293T
MedLine Reference 11328858:1268
CellType myoblast
Journal Mol. Endocrin
Journal Reference v15 i5 p783 (2001)
Journal Link http://mend.endojournals.org/cgi/content/full/15/5/783
Organism mouse
Source Curated
MedLine Reference 11509671:1260
Journal Mol. Cell. Biol
Journal Reference v21 i18 p6312 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/18/6312
Organism yeast
Source Curated
MedLine Reference 10958686:1028
Journal Mol. Cell. Biol
Journal Reference v20 i18 p6904 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/18/6904
Organism mouse
Source Curated
MedLine Reference 12376544:1399
Tissue muscle
Journal J. Biol. Chem
Journal Reference v277 i50 p48889 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/50/48889
Organism drosophila
Source Curated
MedLine Reference 12626519:1049
Organ heart
Tissue skeletal muscle
Journal J. Biol. Chem
Journal Reference v278 i20 p17625 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/20/17625
Source Curated