Protein : DFFB
Owner Public
URN urn:agi-llid:1677
Hugo ID 2773
Connectivity 114
Name DFFB
Description DNA fragmentation factor, beta subunit
Notes endogenous endonuclease; mediates caspase-3-dependent internucleosomal DNA degradation and related nuclear alterations [RGD]
RGD ID 620335
MGI ID 1196287
Cell Localization Nucleus
Pathway FAS signaling
Caspases
Death receptor signaling
TNFR1 signaling
DR3 and DR4-5 pathways
Group intracellular signaling cascade
apoptosis
DNA fragmentation during apoptosis
induction of apoptosis
intracellular
cytosol
nucleus
protein binding
DNA binding
hydrolase activity
nuclease activity
deoxyribonuclease activity
caspase-activated deoxyribonuclease activity
nicotinate phosphoribosyltransferase activity
GenBank ID NC_000001
NM_001004286
NP_001004286
NM_001004285
NP_001004285
NM_004402
NP_004393
NT_004321
NW_923572
AC_000044
AL691523
CAI17370
CAI17371
AB013918
BAA32250
AB028911
BAB40447
AB028912
BAB40448
AB028913
BAB40449
AF039210
AAC39709
AF064019
AAC39920
AF409060
AAL02005
AF409061
AAL02006
AF409062
AAL02007
AY438267
AAR05821
AY438268
AAR05822
BC032827
AAH32827
BC048797
AAH48797
O76075
Q5SR22
Q5SR23
Q96P72
Q96P73
Q96P74
NC_000070
NM_007859
NP_031885
NT_039268
NW_000222
NW_001030773
AC_000026
AL806525
AB009377
BAA24977
AI426042
AK036094
AK077619
BAC36905
AK089267
BC053052
AAH53052
BG086312
O54788
NC_005104
NM_053362
NP_445814
NW_001084844
NW_047731
AC_000073
AF136598
AAK16646
Q99N34
Source Curated
LocusLink ID 1677
13368
84359
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 601883
Alias CAD
CPAN
DFF2
DFF40
DFF-40
DNA fragmentation factor, 40 kD, beta polypeptide
caspase-activated DNase
caspase-activated nuclease
caspase-activated deoxyribonuclease
DNA fragmentation factor, 40 kD, beta subunit
DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase)
40kDa
Didff
5730477D02Rik
DNA fragmentation factor, beta subunit
DNase inhibited by DNA fragmentation factor
DNA fragmentation factor 40 kD beta polypeptide (caspase-activated DNase)
GO ID 0004537
0016787
0004518
0005515
0006309
0006915
0007242
0005829
0005622
0005634
0003677
0004516
0004536
0006917
Swiss-Prot Accession O76075
Q5SR22
Q5SR23
Q96P72
Q96P73
Q96P74
O54788
Q99N34
Unigene ID Hs.133089
Mm.388918
Rn.67077