Protein : CASP3


Owner	Public
URN	urn:agi-llid:836
Hugo ID	1504
Connectivity	2606
Name	CASP3
Description	caspase 3, apoptosis related cysteine protease
Notes	apoptotic cysteine-aspartic acid protease that may play a role in neuronal cell death regulation and other apoptotic processes [RGD]


RGD ID	2275


MGI ID	107739


Pathway	FAS signaling
	Caspases
	Mitochondrial control of Apoptosis
	Death receptor signaling
	TNFR1 signaling
	Inhibition of Apoptosis
	DR3 and DR4-5 pathways
	Apoptosis
	TNFRSF6 -> FOXO3A signaling pathway
	Copy of 'Apoptosis'
	Apoptosis2


Group	intracellular signaling cascade
	neuron differentiation
	cell fate commitment
	keratinocyte differentiation
	negative regulation of progression through cell cycle
	negative regulation of cyclin-dependent protein kinase activity
	apoptosis
	release of cytochrome c from mitochondria
	DNA fragmentation during apoptosis
	induction of apoptosis
	induction of apoptosis via death domain receptors
	induction of apoptosis by oxidative stress
	negative regulation of B cell proliferation
	negative regulation of activated T cell proliferation
	proteolysis
	heart development
	B cell homeostasis
	T cell homeostasis
	response to UV
	response to wounding
	cytoplasm
	cytosol
	protein binding
	hydrolase activity
	peptidase activity
	cysteine-type peptidase activity
	caspase activity
	phospholipase A2 activator activity
	cyclin-dependent protein kinase inhibitor activity


Source	Curated


OMIM ID	600636


Alias	CPP32
	SCA-1
	CPP32B
	caspase 3
	Yama
	apopain
	procaspase3
	PARP cleavage protease
	cysteine protease CPP32
	SREBP cleavage activity 1
	caspase 3, apoptosis-related cysteine protease
	Lice
	Caspase-3
	A830040C14Rik
	caspase 3, apoptosis related cysteine protease
	MGC93645
	CPP32beta
	Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease)
	Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)