ProtModification :


Owner	Public
URN	urn:agi-ProtModification:inout-urn:agi-prot:CrmA:out-urn:agi-llid:834::negative
Entities	CrmA ---\| CASP1
References	1
Connectivity	2
Effect	negative


MedLine Reference	12692130
Sentence	A D126A parkin mutation abrogates cleavage induced by caspase-1 and -8, but not by caspase-3. In anti-Fas-treated Jurkat T cells, parkin cleavage was inhibited by caspase inhibitors hFlip and CrmA (but not by X-linked inhibitor of apoptosis (XIAP)), indicating that caspase-8 (but not caspase-3) is responsible for the parkin cleavage in this model.
Source	Curated