ProtModification :


Owner	Public
URN	urn:agi-ProtModification:inout-urn:agi-llid:317:out-urn:agi-llid:842::positive
Entities	APAF1 --+> CASP9
References	1
Connectivity	2
Effect	positive


MedLine Reference	10528165:1336
Sentence	Since granzyme B is capable of directly activating caspase-3 in intact cells ( 10 , 11 , 12 , 13 , 22 ), one possible role for the Apaf-1/cytochrome c /caspase-9 complex is to amplify the cascade.
Source	Curated