Binding :


Connectivity	2
Owner	Public
URN	urn:agi-Binding:inout-urn:agi-llid:842:inout-urn:agi-llid:331:
Entities	BIRC4 ---- CASP9
References	66


MedLine Reference	15604274:7
Sentence	In addition, XIAP was coimmunoprecipitated with procaspase-9.


MedLine Reference	14523016:6
Sentence	Smac3 disrupts processed caspase-9 binding to XIAP, promotes caspase-3 activation, and potentiates apoptosis.


MedLine Reference	11242052:0
Sentence	X-linked inhibitor-of-apoptosis protein (XIAP) interacts with caspase-9 and inhibits its activity, whereas Smac (also known as DIABLO) relieves this inhibition through interaction with XIAP.


MedLine Reference	14960576:10025
Journal	J. Biol. Chem
Journal Reference	v279 i17 p16963
Journal Link	http://www.jbc.org/cgi/content/full/279/17/16963


MedLine Reference	12874265:10167
Journal	J. Exp. Med
Journal Reference	v198 i2 p341
Journal Link	http://www.jem.org/cgi/content/full/198/2/341


MedLine Reference	14701799:10032
Journal	J. Biol. Chem
Journal Reference	v279 i10 p9023
Journal Link	http://www.jbc.org/cgi/content/full/279/10/9023


MedLine Reference	12954616:10285
Journal	J. Biol. Chem
Journal Reference	v278 i46 p45793
Journal Link	http://www.jbc.org/cgi/content/full/278/46/45793


MedLine Reference	11157976:10180
Journal	J. Cell Biol
Journal Reference	v152 i3 p483
Journal Link	http://www.jcb.org/cgi/content/full/152/3/483


MedLine Reference	11805081:10134
Journal	J. Biol. Chem
Journal Reference	v277 i12 p9633
Journal Link	http://www.jbc.org/cgi/content/full/277/12/9633
Organism	Mus musculus


MedLine Reference	10934209:10150
Journal	J. Biol. Chem
Journal Reference	v275 i43 p33777
Journal Link	http://www.jbc.org/cgi/content/full/275/43/33777


MedLine Reference	15280366:10107
Journal	J. Biol. Chem
Journal Reference	v279 i39 p40622
Journal Link	http://www.jbc.org/cgi/content/full/279/39/40622


MedLine Reference	10930419:10163
Journal	J. Biol. Chem
Journal Reference	v275 i41 p31733
Journal Link	http://www.jbc.org/cgi/content/full/275/41/31733


MedLine Reference	14512414:10155
Journal	J. Biol. Chem
Journal Reference	v278 i49 p49517
Journal Link	http://www.jbc.org/cgi/content/full/278/49/49517


MedLine Reference	12591734:5
Organism	Mus musculus
CellLineName	H460


MedLine Reference	16352606:6
CellLineName	MCF7


MedLine Reference	12181739:3


MedLine Reference	101002407:11025
Journal	Cell
Journal Reference	v102 i1 p33
Journal Link	http://www.cell.com/cgi/content/full/102/1/33


MedLine Reference	106100532:11138
Journal	EMBO
Journal Reference	v24 i3 p7600544
Journal Link	http://www.nature.com/emboj/journal/v24/n3/full/7600544a.html


MedLine Reference	15118177:10084
Journal	Stroke
Journal Reference	v35 i6 p1443
Journal Link	http://stroke.ahajournals.org/cgi/content/full/35/6/1443
Organism	Mus musculus


MedLine Reference	11406588:10168
Journal	EMBO
Journal Reference	v20 i12 p3114
Journal Link	http://emboj.oupjournals.org/cgi/content/full/20/12/3114


MedLine Reference	14657037:10154
Journal	EMBO
Journal Reference	v22 i24 p6665
Journal Link	http://emboj.oupjournals.org/cgi/content/full/22/24/6665
Organism	Mus musculus


MedLine Reference	11356822:10025
Journal	J. Biol. Chem
Journal Reference	v276 i27 p24453
Journal Link	http://www.jbc.org/cgi/content/full/276/27/24453


MedLine Reference	15126334:10096
Journal	Cancer Res
Journal Reference	v64 i9 p3006
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/64/9/3006


MedLine Reference	12481428:10026
Journal	Mol. Cancer Ther
Journal Reference	v1 i12 p1051
Journal Link	http://mct.aacrjournals.org/cgi/content/full/1/12/1051


MedLine Reference	11604410:10256
Journal	J. Biol. Chem
Journal Reference	v277 i1 p445
Journal Link	http://www.jbc.org/cgi/content/full/277/1/445


MedLine Reference	11606597:10149
Journal	J. Biol. Chem
Journal Reference	v277 i1 p432
Journal Link	http://www.jbc.org/cgi/content/full/277/1/432


MedLine Reference	9545235:10114
Journal	EMBO
Journal Reference	v17 i8 p2215
Journal Link	http://emboj.oupjournals.org/cgi/content/full/17/8/2215


MedLine Reference	14993223:10409
Journal	J. Biol. Chem
Journal Reference	v279 i19 p19665
Journal Link	http://www.jbc.org/cgi/content/full/279/19/19665


MedLine Reference	11230124:10177
Journal	EMBO
Journal Reference	v20 i5 p998
Journal Link	http://emboj.oupjournals.org/cgi/content/full/20/5/998


MedLine Reference	15914467:10420
Journal	Pharm. Rev
Journal Reference	v57 i2 p187
Journal Link	http://pharmrev.aspetjournals.org/cgi/content/full/57/2/187


MedLine Reference	11390657:10223
Journal	Mol. Cell. Biol
Journal Reference	v21 i13 p4292
Journal Link	http://mcb.asm.org/cgi/content/full/21/13/4292


MedLine Reference	14695204:10237
Journal	Cancer Res
Journal Reference	v63 i24 p8869
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/63/24/8869


MedLine Reference	106100207:11066
Journal	EMBO
Journal Reference	v23 i10 p7600210
Journal Link	http://www.nature.com/emboj/journal/v23/n10/full/7600210a.html


MedLine Reference	101002734:11122
Journal	Cell
Journal Reference	v104 i5 p791.1
Journal Link	http://www.cell.com/cgi/content/full/104/5/791.1


MedLine Reference	101002735:11123
Journal	Cell
Journal Reference	v104 i5 p791
Journal Link	http://www.cell.com/cgi/content/full/104/5/791


MedLine Reference	101002406:11025
Journal	Cell
Journal Reference	v102 i1 p33.1
Journal Link	http://www.cell.com/cgi/content/full/102/1/33.1


MedLine Reference	15300255
Sentence	XIAP interacts with and ubiquitinates Caspase-9
Source	Curated


MedLine Reference	11782351:1160
Sentence	XIAP binds and inhibits caspases 3, 7, and 9 (23 , 24) .
Journal	Cancer Res
Journal Reference	v62 i1 p18 (2002)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/62/1/18
Organism	horse
Source	Curated
CellLineName	HeLa


MedLine Reference	12591734:1012
Sentence	Moreover, the defect in apoptosome activity in H460 cells was dramatically restored by the IAP-targeting SmacN7 peptide, which disrupted XIAP-caspase-9 binding, indicating an essential role of the IAP in the apoptosome inhibition.
Journal	Cancer Res
Journal Reference	v63 i4 p831 (2003)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/63/4/831
Organism	mouse
Source	Curated
CellLineName	H460


MedLine Reference	14512414:1157
Journal	J. Biol. Chem
Journal Reference	v278 i49 p49517 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/49/49517
Source	Curated


MedLine Reference	12954616:1229
Journal	J. Biol. Chem
Journal Reference	v278 i46 p45793 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/46/45793
Source	Curated
CellLineName	MOCK


MedLine Reference	11805081:1134
Journal	J. Biol. Chem
Journal Reference	v277 i12 p9633 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/12/9633
Organism	mouse
Source	Curated
CellLineName	HEK 293


MedLine Reference	11604410:1257
Journal	J. Biol. Chem
Journal Reference	v277 i1 p445 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/1/445
Source	Curated


MedLine Reference	11356822:1026
Journal	J. Biol. Chem
Journal Reference	v276 i27 p24453 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/27/24453
Source	Curated


MedLine Reference	10934209:1150
Journal	J. Biol. Chem
Journal Reference	v275 i43 p33777 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/43/33777
Source	Curated


MedLine Reference	9545235:1116
CellType	reticulocyte
Journal	EMBO
Journal Reference	v17 i8 p2215 (1998)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/17/8/2215
Source	Curated
CellLineName	293


MedLine Reference	11230124:1156
Journal	EMBO
Journal Reference	v20 i5 p998 (2001)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/20/5/998
Source	Curated


Journal	Cell
Journal Reference	v104 i5 p791 (2001)
Journal Link	http://www.cell.com/cgi/content/full/104/5/791
Source	Curated


Journal	Cell
Journal Reference	v104 i5 p791 (2001)
Journal Link	http://www.cell.com/cgi/content/full/104/5/791
Source	Curated


Journal	Cell
Journal Reference	v104 i5 p791.1 (2001)
Journal Link	http://www.cell.com/cgi/content/full/104/5/791.1
Source	Curated


Journal	Cell
Journal Reference	v104 i5 p791.1 (2001)
Journal Link	http://www.cell.com/cgi/content/full/104/5/791.1
Source	Curated


Journal	Cell
Journal Reference	v102 i1 p33 (2000)
Journal Link	http://www.cell.com/cgi/content/full/102/1/33
Source	Curated


MedLine Reference	11927604
Source	Curated


MedLine Reference	11390656:1219
Journal	Mol. Cell. Biol
Journal Reference	v21 i13 p4292 (2001)
Journal Link	http://mcb.asm.org/cgi/content/full/21/13/4292
Organism	yeast
Source	Curated


MedLine Reference	12481428:1026
Journal	Mol. Cancer Ther
Journal Reference	v1 i12 p1051 (2002)
Journal Link	http://mct.aacrjournals.org/cgi/content/full/1/12/1051
Source	Curated


MedLine Reference	11160384:1020
Journal	J. Neurosci
Journal Reference	v21 i4 p1137 (2001)
Journal Link	http://www.jneurosci.org/cgi/content/full/21/4/1137
Organism	rat
Source	Curated


CellType	b cell
Journal	J. Exp. Med
Journal Reference	v198 i2 p341 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/2/341
Source	Curated
CellLineName	HL


CellType	b cell
Journal	J. Exp. Med
Journal Reference	v198 i2 p341 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/2/341
Source	Curated
CellLineName	HL


CellType	b cell
Journal	J. Exp. Med
Journal Reference	v198 i2 p341 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/2/341
Source	Curated
CellLineName	HL


CellType	b cell
Journal	J. Exp. Med
Journal Reference	v198 i2 p341 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/2/341
Source	Curated
CellLineName	HL


MedLine Reference	11157976:1025
Journal	J. Cell Biol
Journal Reference	v152 i3 p483 (2001)
Journal Link	http://www.jcb.org/cgi/content/full/152/3/483
Organism	drosophila
Source	Curated


MedLine Reference	11825888:1022
Journal	J. Biol. Chem
Journal Reference	v277 i16 p13693 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/16/13693
Organism	mouse
Source	Curated


MedLine Reference	10950947:1129
Journal	J. Biol. Chem
Journal Reference	v275 i46 p36152 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/46/36152
Source	Curated


MedLine Reference	14523016:1414
Journal	J. Biol. Chem
Journal Reference	v278 i52 p52660 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/52/52660
Source	Curated


MedLine Reference	12620238
Source	Curated


MedLine Reference	3219526653
Sentence	Three human IAPs, XIAP, c-IAP-1, and c-IAP-2 have been shown to bind procaspase-9 and prevent its activation (Deveraux et al., 1998 ).
Journal	Cell
Journal Reference	v102 i1 p33 (2000)
Journal Link	http://www.cell.com/cgi/content/full/102/1/33
Source	Curated